EXPANDING NATIVE MASS SPECTROMETRY CAPABILITIES FOR SOLUBLE AND MEMBRANE PROTEINS USING A QUADRUPOLE-ION MOBILITY-TIME-OF-FLIGHT MASS SPECTROMETRY SYSTEM

Application Note Native Mass Spectrometry of Membrane Protein-Ligand Complexes Using the SELECT SERIES™ Cyclic™ IMS Dale Cooper-Shepherd, Feng Qu, Kleitos Sokratous, Jonathan T. S. Hopper Waters Corporation, OMass Therapeutics This is an Application Brief and does not contain a detailed…

Waters Cyclic IMS P20 Mass Spectrometer Insight—revealed, not inferred. Insight— revealed, not inferred Biological systems are inherently complex, and answering today’s research questions requires tools that can reveal that complexity with clarity. The Waters™ Cyclic™ IMS P20 Mass Spectrometer enables…

Developing a declustering ion guide and Cyclic IMS-enabled Wideband Enhancement for native top-down studies Isabella A. Jones1, Dale A. Cooper-Shepherd2, Emma Marsden-Edwards2 1University of Birmingham, Birmingham, United Kingdom; 2Waters Corporation, Wilmslow, United Kingdom INTRODUCTION • • • • • •…

DEVELOPMENT OF A MODIFIED CYCLIC IMS PLATFORM FOR ENHANCED BIOMOLECULE CHARACTERIZATION Bryan J. McCullough1, Dale A. Cooper-Shepherd1, Darren Hewitt1, David Harker1 & Emma Marsden-Edwards1 1. Waters Corporation, Stamford Avenue, Altrincham Rd., Wilmslow, UK INTRODUCTION Tof duty cycle is inherently limited…