Oligonucleotide Workflow Incorporating Nuclease-Conjugated Beads with LC-MS/MS

Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…

Application Note Tunable Digestions of RNA Using RapiZyme™ RNases to Confirm Sequence and Map Modifications Balasubrahmanyam Addepalli, Tatiana Johnston, Christian Reidy, Matthew A. Lauber Waters Corporation Abstract RNA therapeutics such as sgRNA and mRNA are important modalities for Gene Therapy…

Application Note RNA Digestion Product Mapping Using an Integrated UPLC-MS and Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract LC-MS analysis is an indispensable tool for single-guide RNA (sgRNA)…

Characterization of mRNA Therapeutics Using a Novel LC-MS Based Workflow Angela Criscuolo3, Tabiwang Arrey3, Andrew Williamson2, Ken Cook2, Keeley Murphy1, Jennifer Sutton1, Alexander Harder3, Jim Shofstahl1, Mark Sanders1 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Hemel Hempstead,…