mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS

Oligonucleotide sequencing by LC-MS/MS: A novel Approach for Characterization and Quality Control of mRNA-based Vaccines and Biotherapeutics Alexander Schwahn, Angela Criscuolo, and Ken Cook The world leader in serving science 1 [email protected] | ISC2022 Why have oligonucleotides become so popular?…

Biopharmaceuticals Analytical solutions for mRNA vaccines and therapeutics Table of contents mRNA vaccines and therapeutics mRNA characterization Lipid nanoparticle characterization Critical quality attributes of mRNA therapeutics Direct mRNA sequence confirmation LNP composition analysis by LC-CAD Optimize impurity analysis with ease…

Blueprint for QC-ready mRNA mapping with Thermo Fisher Scientific and the University of Sheffield Thermo Fisher has a long-standing collaboration with Professor Mark J. Dickman and the University of Sheffield, where his lab is pioneering automated, high-resolution LC–MS/MS workflows for…

Characterization of mRNA Therapeutics Using a Novel LC-MS Based Workflow Angela Criscuolo3, Tabiwang Arrey3, Andrew Williamson2, Ken Cook2, Keeley Murphy1, Jennifer Sutton1, Alexander Harder3, Jim Shofstahl1, Mark Sanders1 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Hemel Hempstead,…