RNA Digestion Product Mapping Using an Integrated UPLC-MS and Informatics Workflow

Application Note Oligo Mapping of mRNA Digests Using a Novel Informatics Workflow Catalin E. Doneanu, Chris Preston, Matt Gorton, Tatiana Johnson, Bala Addepalli, Ying Qing Yu Waters Corporation Abstract Recent advances in LC-MS and informatics technologies are supporting scientists in…

Application Note Oligo Mapping of sgRNA Digests: Leveraging Xevo MRT Mass Spectrometer Performance and Streamlining Data Analysis Catalin Doneanu, Alexandre F Gomes, Tatiana Johnston, Chris Preston, Matt Gorton, Bala Addepalli, Scott Berger, Ying Qing Yu Waters Corporation, Milford, MA, United…

Application Note Tunable Digestions of RNA Using RapiZyme™ RNases to Confirm Sequence and Map Modifications Balasubrahmanyam Addepalli, Tatiana Johnston, Christian Reidy, Matthew A. Lauber Waters Corporation Abstract RNA therapeutics such as sgRNA and mRNA are important modalities for Gene Therapy…

RNA SEQUENCE MAPPING VIA ENDONUCLEASE DIGESTION AND LC-MS ANALYSIS VIA NOVEL INFORMATICS WORKFLOWS Catalin Doneanu1, Chris Preston2, Matt Gorton2, Alexandre F. Gomes1, Tatiana Johnston1, Bala Addepalli1, Nick Pittman2 and Ying Qing Yu1 1 Waters Corporation, Milford, MA, USA; 2Waters Corporation,…