Probe the Protein Conformation using Top-down Hydrogen Exchange Mass Spectrometry at Higher Resolution with Electron Transfer Dissociation

Poster # P-I-0178 Probe the protein conformation using top-down hydrogen exchange mass spectrometry at higher resolution with electron transfer dissociation Yuqi Shi1, Graeme McAlister1, Rosa Viner1, 1Thermo Fisher Scientific, San Jose, CA Abstract Results Purpose: Study protein, protein/complex conformations by…

WHITE PAPER 65872 Hydrogen deuterium exchange mass spectrometry for the masses Executive summary Determining the shape and dynamics of proteins and protein complexes is crucial to understanding protein function and the roles proteins play in biological systems. Traditional techniques employed…

PROBING SITE-SPECIFIC INTERACTIONS BETWEEN EPIDERMAL GROWTH FACTOR RECEPTOR AND AN ADNECTIN USING HDX-ETD MS APPROACH Jing Fang1 , Asish Chakraborty1, Ying Qing Yu1, Hui Wei2, Jingjie Mo2, Daniel Cohen3, Dianlin Xie3, Zheng Lin3, Paul E. Morin3, Michael L. Doyle3, Adrienne…

Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu Waters Corporation, Milford, MA, U.S. A P P L I C AT I O N B E N…