Sensitive Bioanalysis Method for Antisense Oligonucleotides using LC-MS/MS

Application Note Oligonucleotide Analysis Molecular Confirmation of Oligonucleotides Using Agilent LC/MSD XT and OpenLab CDS Author Abstract Lee Bertram and Brian Rivera Agilent Technologies, Inc. Mass spectrometry (MS) is an important tool for quality control during the development of synthetic…

Application Note Biopharma Oligonucleotide Mass Confirmation and Impurity Identification Using Agilent InfinityLab LC/MSD XT and Agilent OpenLab CDS Author Bian Yulan Agilent Technologies, Inc. Abstract This application note highlights the use of the Agilent InfinityLab LC/MSD XT system on molecular…

Poster Reprint ASMS 2025 Poster number ThP 565 High-throughput Ion-Pairing Free Reversed Phase Analysis of Oligonucleotides using RapidFire Quadrupole Time-of-Flight Mass Spectrometry Guannan Li and Lee Bertram Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Oligonucleotides are commonly analyzed by…

Application Note Pharma & Biopharma Oligonucleotides Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF Oligonucleotide identity, impurities analysis and sequence determination using BioConfirm 12.0 target plus impurities (TPI) and sequence confirmation workflows Authors Introduction Bian…