Exploring the power of the timsTOF Ultra to investigate the HLA immunopeptidome with high sensitivity and accuracy, allowing for smaller sample sizes while maintaining a robust immunopeptidome

Technical note | 003923 Omics Unlocking the immunopeptidome High-sensitivity and accurate mass spectrometry with the Orbitrap Astral Zoom mass spectrometer for superior antigen characterization Authors Goal Fernanda Salvato1, Nicholas Cheung2, To assess depth and quality of immunopeptidome coverage using data-dependent…

Case study | 003393 Omics Immunopeptidomics: Harnessing cutting-edge technology for unprecedented depth and accessibility in analysis to leverage the immune response for precision therapy Introduction Rethink what is possible Immunopeptidomics is the study of the peptides presented by The Orbitrap…

ASMS 2022 – ThP 454 Enhanced Sensitivity and Reproducibility for HLA-Class I & II Immunopeptidomics Utilizing dia-PASEF Workflow Diego M Assis1; Nicholas Cheung2; Jonathan R Krieger3; Daniel Hornburg4; Michael Krawitzky4; Matthew Willetts5; Robert Salzler2 1Bruker Scientific LLC, Billerica, MA; 2Regeneron,…

Translating peptide evidence into immunotherapy targets: Orbitrap Tribrid Apex MultiOmics MS delivers high-confidence spectral annotation Fernanda Salvato1, Christopher Mullen1, Josh Hinkle1, Graeme McAlister1, Annastasia Klenkle2, Bhavin Patel2, Rafael Melani1, Tonya Pekar Hart1 1 Thermo Fisher Scientific, San Jose, CA; 2…