IMSIS: TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS

TOWARDS IN-VITRO DIAGNOSTIC IMAGING OF HEPA-RG SPHEROIDS BY DESI TANDEM QUADRUPOLE MS Mark Towers1, Lisa Reid1, Alicia Rosell-Hidalgo2, Kirsten Headspith2 1 Waters Corporation, Wilmslow, Cheshire, UK 2 Cyprotex Ltd., Alderley Park, Cheshire, UK INTRODUCTION RESULTS AND DISCUSSION Dilution series Carbamazepine…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUGINDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT Anthony Midey,1 Emmanuelle Claude,2 Lisa Reid,2 Bindesh Shrestha,1 Steven K Lai,1 Ian D Wilson,3 Robert S Plumb,1 and Roy Martin1…

IMPROVING SPATIAL DISTRIBUTION, SENSITIVITY AND SELECTIVITY IN MSI, USING A NOVEL DESI QQQ AND A HR-MULTI REFLECTING TOF SYSTEMS Emmanuelle Claude1; Farid Jahouh2; Martin Palmer1; Inneke Wynant2; Filip Cuyckens2, Marjolein Van Heerden2; Jan Claereboudt3; Rob J Vreeken2,4, Lance Nicolaysen5 1…