TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUG- INDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT

APPLICATION OF TARGETED LIPIDOMICS TO DETERMINE CHANGES IN THE PLASMA LIPIDOME OF MALE RATS FOLLOWING REPEAT ORAL ADMINISTRATION OF METHAPYRILENE Authors: Roy Martin1, Anthony Midey1, Ian D Wilson2, Robert S Plumb1 Affiliations: 1 Waters Corporation, Milford, MA, USA, 2 Imperial…

Investigating The Relationship Between Off Target Pharmacology & The DMPK of Methapyrilene Using Lipidomics And MS Imaging. Abstract ID number: 322543 Authors: 1Andrew Leightner, 1Anthony Middey, 1Steven K Lai, 1Robert S Plumb, 2Ian D Wilson Affiliations: 1Waters Corporation, Milford, MA,…

Tandem Quadrupole DESI Imaging To Visualize Spatial Distribution of Gefitinib and Related Metabolites in Rat Liver Anthony J. Midey,1 Robert Plumb,1 Nikunj Tanna,1 and Ian D. Wilson2 1Waters Corp., Milford, MA, USA; 2Imperial College London, London, UK Study Design Samples…

LIPIDOMIC AND DESI IMAGING STUDY OF MOUSE LIVER DOSED WITH A TYROSINE KINASE INHIBITING DRUG Nyasha Munjoma 1 , Giorgis Isaac 2 , Mark Towers 1 , Emmanuelle Claude 1 , Ian D Wilson 3 , Lee A. Gethings 1…