EBF: ELEMENTS OF ROBUST MODIFIED OLIGONUCLEOTIDE EXTRACTION THROUGH SPE

M0930-06-36 ELEMENTS OF ROBUST MODIFIED OLIGONUCLEOTIDE EXTRACTION THROUGH SPE Makda Araya, Abraham Finny, Balasubrahmanyam Addepalli and Matthew Lauber Waters Corporation CONTACT INFORMATION: [email protected] PURPOSE RESULTS Extraction and Quantification of Therapeutic Oligonucleotides (OTx) during Bioanalysis Robust extraction of modified and unmodified…

[ CONSUMABLES GUIDE BOOK ] Quantifying Oligonucleotides Sample Extraction and LC Tools for Reliable LC-MS Quantitation of Oligonucleotides A Changing Industry There has been a resurgence in synthetic oligonucleotide therapeutics in the past decade, as seen with burgeoning pipelines across…

Application Note Improved Recovery of a Lipid Conjugated Antisense Oligonucleotide from Human Plasma using the OligoWorks™ SPE Microplate Kit and an Optimized Protocol Mary Trudeau, Matthew A. Lauber Waters Corporation This is an Application Brief and does not contain a…

Application Note Improved Bioanalytical Extraction of Therapeutic Antisense Oligonucleotides, Including a Lipid Conjugated ASO From Liver and Brain Tissue Using the OligoWorks™ SPE Microplate Kit Makda Araya, Mary Trudeau, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract To develop and…