ELEMENTS OF ROBUST MODIFIED OLIGONUCLEOTIDE EXTRACTION THROUGH SPE

ELEMENTS OF ROBUST MODIFIED OLIGONUCLEOTIDE EXTRACTION THROUGH SPE Makda Araya, Abraham Finny, Balasubrahmanyam Addepalli, Mandana Fasth and Matthew Lauber Waters Corporation INTRODUCTION RESULTS AND DISCUSSION Extraction and Quantification of Therapeutic Oligonucleotides (OTx) during Bioanalysis Robust extraction of modified and unmodified…

Application Note Quantification of a Lipid Conjugated Antisense Oligonucleotide (ASO) Extracted From Rat Plasma Using the OligoWorks™ SPE Microplate Kit on a HRMS System Nikunj Tanna, Mary Trudeau Waters Corporation Abstract Discovery bioanalysis laboratories play a critical role in the…

[ CONSUMABLES GUIDE BOOK ] Quantifying Oligonucleotides Sample Extraction and LC Tools for Reliable LC-MS Quantitation of Oligonucleotides A Changing Industry There has been a resurgence in synthetic oligonucleotide therapeutics in the past decade, as seen with burgeoning pipelines across…

Application Note Improved Recovery of a Lipid Conjugated Antisense Oligonucleotide from Human Plasma using the OligoWorks™ SPE Microplate Kit and an Optimized Protocol Mary Trudeau, Matthew A. Lauber Waters Corporation This is an Application Brief and does not contain a…