Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer

Application note | 002679 Biopharma Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry Authors Application benefits Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of antisense oligonucleotides with human Jon…

Ultra-sensitive quantitation of therapeutic oligonucleotide in human plasma by a high resolution accurate mass Orbitrap mass spectrometer Hao Yang1, Min Du2, 1Thermo Fisher Scientific, San Jose, CA, United States, 2Thermo Fisher Scientific, Lexington, MA, United States Abstract We developed a…

T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…

Application Note Analytical Solutions and Method Development Considerations for Quantitative Bioanalytical Oligonucleotide Studies Marian Twohig, Catalin Doneanu, Margot Lee, Nikunj Tanna, Mary Trudeau Waters Corporation, United States Published on November 24, 2025 Abstract Oligonucleotide therapeutics are gaining momentum as innovative…