Analytical Solutions and Method Development Considerations for Quantitative Bioanalytical Oligonucleotide Studies

Application Note Quantification of Biopharmaceuticals in Plasma Using a Multiple Charge Stage Calibration Line Marian Twohig, Robert Plumb Waters Corporation, United States Published on April 29, 2026 This is an Application Brief and does not contain a detailed Experimental section.…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

BIOANALYTICAL QUANTIFICATION OF A LIPID CONJUGATED ANTI-SENSE OLIGONUCLEOTIDE ON A HRMS SYSTEM Authors: Nikunj Tanna, Joe Fredette and Mary Trudeau Affiliations INTRODUCTION METHODS SPE METHOD OPTIMIZATION Oligonucleotide therapeutics (ONTs) are a key focus area for many drug developers today given…

Application Note Quantification of a Lipid Conjugated Antisense Oligonucleotide (ASO) Extracted From Rat Plasma Using the OligoWorks™ SPE Microplate Kit on a HRMS System Nikunj Tanna, Mary Trudeau Waters Corporation Abstract Discovery bioanalysis laboratories play a critical role in the…