LC/UV/HRAM MS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis

Biopharma LC/UV/HRMS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis S. Hackbusch1, G. Held2, S.K. Raza2, K. Chodara2, Y. Zhang1, M. Du1. 1 Thermo Fisher Scientific, San Jose, CA 95134, USA, 2 Thermo Fisher Scientific,…

Application note | 002455 Biotech Confident and sensitive profiling of lipid nanoparticle raw materials and impurity identification using a LC/CAD/HRAM-MS method with inverse gradient Authors Application benefits Sven Hackbusch , Sissi White , Min Du 1 2 2 • Confident…

Application Note Biopharma and Pharma Identification of Commercially Available Oligonucleotide Starting Materials Directly Through Containers Authors Frederic Pulliere and Christopher Welsby Agilent Technologies, Inc. Abstract Handheld Raman spectrometers can selectively identify oligonucleotide starting materials, also known as phosphoramidites, directly through…

Application Note Biopharma/Pharma Analyzing Raw Material for Oligonucleotide Synthesis Flexible and robust method development for the analysis of nucleoside phosphoramidites with the Agilent 1290 Infinity II Bio LC System 100 Response (mAU) 80 60 40 20 0 0 5 10…