LC/UV/HRMS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis

Application note | 001949 Biotech LC/UV/HRAM MS-based impurity profiling and structure elucidation of phosphoramidite raw materials used for oligonucleotide synthesis Application benefits Authors Sven Hackbusch , Gary Held , Yi Zhang , 1 Min Du 2 3 • Sensitive detection…

Application Note Raw Material Testing: Developing Methods for Quality Control of Phosphoramidites used in the Chemical Synthesis of Oligonucleotides Brooke M. Koshel, Jennifer M. Nguyen, Matthew A. Lauber, Katrien Donckers, Willy Verluyten, Irene Suarez Marina, Jean-Paul Boon, Mario Hellings Waters…

Application note | 002455 Biotech Confident and sensitive profiling of lipid nanoparticle raw materials and impurity identification using a LC/CAD/HRAM-MS method with inverse gradient Authors Application benefits Sven Hackbusch , Sissi White , Min Du 1 2 2 • Confident…

Application Note Biopharma and Pharma Identification of Commercially Available Oligonucleotide Starting Materials Directly Through Containers Authors Frederic Pulliere and Christopher Welsby Agilent Technologies, Inc. Abstract Handheld Raman spectrometers can selectively identify oligonucleotide starting materials, also known as phosphoramidites, directly through…