Oligonucleotide sequencing by LC-MS/MS

Customer application note | 000723 Biotechnology mRNA direct sequence mapping using automated partial digestion with magnetic nuclease and LC-HRMS Authors Application benefits Mark Dickman1, Christina Vanhinsbergh1, Jon Bardsley , Ken Cook , Andrew 2 2 Williamson2, Jennifer Sutton3, Keeley Murphy3…

High-throughput LC/MS characterization of mRNA therapeutics using a fast DDA method on the Orbitrap Astral MS Tabiwang Arrey1; Angela Criscuolo1; Matthew James Garland1, Bernd Hagedorn1, Keeley Murphy2; Eugen Damoc1, 1Thermo Fisher Scientific, Bremen, Germany; 2Thermo Fisher Scientific, San Jose, CA…

Myth busting: “You cannot sequence oligonucleotides over 20 to 30 nucleotides long by LCMS/MS” Learn how to routinely sequence 100 nt oligonucleotides Alexander Schwahn1, Ulrik Mistarz2, Keeley Murphy3, and Ken Cook4; Thermo Fisher Scientific: 1) Reinach, Switzerland; 2) Copenhagen, Denmark;…

APPLICATION NOTE 73789 Oligonucleotide mapping using BioPharma Finder software Authors: Haichuan Liu1, Kevin Guo2, Jennifer Sutton1, Min Du2 Thermo Fisher Scientific, San Jose, CA Thermo Fisher Scientific, Boston, MA 1 2 Keywords: Oligonucleotide, DNA, RNA, data dependent acquisition, tandem mass…