ENHANCED DECLUSTERING AND CHARGE-STRIPPING ENABLES MASS DETERMINATION OF AAVS IN TOF MS

EXAMINING THE M/Z SEPARATIVE CAPABILITY OF TRAVELLING WAVES FOR LARGE MOLECULE CHARACTERISATION Jakub Ujma,1 David Langridge,1 Keith Richardson,1 Kamila Pacholarz,2 Ellen Liggett,3 Jason Wildgoose,1 Perdita Barran,3 Ian Anderson,4 Kevin Giles,1 Malcolm Anderson1 1. Waters Corporation, Wilmslow, United Kingdom; 2. KP…

STABILITY CHARACTERIZATION OF MULTIPLE SEROTYPES OF ADENO-ASSOCIATED VIRUS USING CHARGE DETECTION MASS SPECTROMETRY 1 Rachel Koerber, 2Anisha Haris 1Susan Abbatiello and 1Andy Jarrell 1 Waters Corporation, Milford, MA, 2Waters Corporation, Wilmslow SK9 4AX, United Kingdom INTRODUCTION RESULTS Adeno-Associated Virus (AAV)…

Comprehensive analysis of adeno-associated virus quality using 3 µm monodisperse Strong Anion Exchange and Size Exclusion chromatography columns Christof Mitterer1, Ke Ma2, Steven Milian3, Shane Bechler2 and Shanhua Lin2 1Thermo Fisher Scientific, Am Parir 20, 52379 Langerwehe, Germany - 2Thermo…

Customer note | 001049 Biotechnology Quantitative analysis of genome packaging in adeno-associated viruses using native MS Authors Key benefits Lisa Strasser1*, Tomos E. Morgan1, Felipe • Intact native mass spectrometry (MS) for the analysis of AAV-based viral vectors does not…