Characterization and Comparison of Neulasta and its Biosimilar at Intact Level on a Quadrupole- Orbitrap Mass Spectrometer

Capillary Chromatography for Therapeutic Proteins and Their Subunit Analysis Using MAbPac RP Column Figure 1. Effect of Flow Rate on Sensitivity/Glycoform Distribution 40 20 0 4 D) Relative Abundance 100 16 15 ng 60 40 40 100 8 12 Time…

APPLICATION NOTE 21880 Comparing biosimilars using intact mass analysis under denaturing and native conditions Authors Sara Carillo, Izabela Zaborowska, Jonathan Bones National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland Keywords NIBRT, biopharmaceutical, biotherapeutic, monoclonal antibody (mAb), IgG, biosimilar,…

Middle Down Analysis of HERCEPTIN and its Biosimilar on a Quadrupole-Ion Trap-Orbitrap Mass Spectrometer using Multiple Fragmentations Xiaoxi Zhang1; Hao Yang2; Haichuan Liu2; Min Du3. 1 ThermoFisher Scientific, Shanghai, China; 2 ThermoFisher Scientific, San Jose, California, US; 3 ThermoFisher Scientific,…

Application note | 002455 Biotech Confident and sensitive profiling of lipid nanoparticle raw materials and impurity identification using a LC/CAD/HRAM-MS method with inverse gradient Authors Application benefits Sven Hackbusch , Sissi White , Min Du 1 2 2 • Confident…