OLIGONUCLEOTIDE SAMPLE PREP & QUANTITATION: IMPROVED SPE PERFORMANCE USING A NOVEL SEMI- AUTOMATED EXTRACTION MANIFOLD

Application Note LC-MS Bioanalytical Quantification of a GalNAc-siRNA Conjugate Oligonucleotide Using Semi-Automated Solid Phase Extraction Mary Trudeau, Kathryn Brennan Waters Corporation Abstract The following work demonstrates the capabilities of the Pipette+ in combination with the Otto SPEcialist for semi-automated liquid…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

Application Note Otto SPEcialist Positive Pressure Manifold Enables Quick, Easy, and Reproducible Peptide Method Development and Quantification Caitlin Dunning, Mark Wrona Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract The Otto SPEcialist…

Sample Preparation and Laboratory Automation Sample Preparation and Laboratory Automation Contents Goals of Sample Preparation........................5 Benefits of Solid-Phase Extraction............5 PoraPak Rxn Cartridges for Post-Synthesis Cleanup................................34 Vacuum Manifold and Accessories........35 Selecting the Correct SPE Format.............6 Vacuum Manifold for Use with SPE…