Multiple ion activations and proton transfer charge reduction facilitate the characterization of capsid proteoforms of recombinant adeno-associated virus 6 (rAAV6)

Application note | 002599 Biopharma Characterization of adeno-associated viral proteins proteoforms using a top-down MS approach on a UHPLC-Orbitrap Ascend Tribrid mass spectrometer Application benefits Authors Reiko Kiyonami , Rafael Melani , 1 1 • Confident determination of PTM localization…

Characterization of Adeno-Associated Viral assemblies on an Ultra-High Mass Range Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Marc Günder1 1Thermo Fisher Scientific, Reinach, Switzerland 2Thermo Fisher Scientific, Bremen, Germany ABSTRACT Purpose: Evaluate the performance of the Thermo Scientific™ Q…

APPLICATION NOTE 000253 Highly sensitive intact mass analysis of AAV capsid proteins using a UHPLC-FLDHRAM MS platform Authors: Reiko Kiyonami¹, Kristina Srzentić², Rosa Viner¹, Weijing Liu¹, Min Du², Katy Irvin³, Kenneth Thompson³, Chao Yan Liu³, Jon Zmuda³ ¹ Thermo Fisher…

APPLICATION NOTE 000242 Adeno-associated virus capsid protein characterization and host cell protein profiling using micro-flow UHPLC-Orbitrap MS Authors: Reiko Kiyonami1, Jennifer Sutton1, Katy Irvin2, Ken Cook3, Estee Toole4, Min Du5 Thermo Fisher Scientific, San Jose, CA; 2 Thermo Fisher Scientific,…