Determination of Nitrosamine Impurities in Losartan Potassium Drug Substance and Drug Product using the Xevo TQ-S micro and Atlantis Premier BEH C18 AX Column

[ APPLICATION NOTE ] High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug Product using the Waters ACQUITY UPLC I-Class/Xevo TQ-XS Tandem Quadrupole Mass Spectrometer Mary Trudeau Lame and Lindsay Hatch Waters Corporation, Milford, MA, USA APPLICATION…

Application Note High Sensitivity Quantification of Nitrosamines in Metformin Using Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer With an ACQUITY™ Premier System Margaret Maziarz, Paul D. Rainville, Amy Bartlett Waters Corporation Abstract The presence of nitrosamine impurities in the pharmaceutical…

[ TECHNOLOGY BRIEF ] Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Lindsay Hatch, Mary Lame, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA The Xevo TQ-XS Mass Spectrometer,…

Poster Reprint ASMS 2020 WP 555 Determination of Nitrosamine impurities in Losartan Potassium drug substance using Triple Quadrupole Liquid Chromatography Mass Spectrometry Chander Mani ,Saikat Banerjee and Samir Vyas (Agilent Technologies, India.) Introduction The announcement for the recall of ARB…