High Sensitivity Quantitation of Nitrosamine Genotoxic Impurities: LC-MS Analysis of Ranitidine Drug Product using the Waters ACQUITY UPLC I-Class/Xevo TQ-XS Tandem Quadrupole Mass Spectrometer

Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Mary Trudeau Lame , Lindsay Hatch, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA 2. UPLC Chromatographic Separation of Nitrosamine Impurities…

[ TECHNOLOGY BRIEF ] Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Lindsay Hatch, Mary Lame, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA The Xevo TQ-XS Mass Spectrometer,…

Application Note Pharmaceuticals Simultaneous Estimation of Eleven Nitrosamine Impurities in Metformin Drug Product Using an Agilent 6495D LC/TQ Authors Abstract Preeti Bharatiya, Prasanth Joseph, Vivek Dhyani, and Saikat Banerjee Agilent Technologies, Inc. This application note presents a comprehensive analytical method…

Application Note Pharmaceuticals Determination of Nitrosamine Impurities Using the Ultivo Triple Quadrupole LC/MS Detection of regulated genotoxic impurities from the drug manufacturing process Authors Chander Mani and Saikat Banerjee Agilent Technologies, Inc. Abstract Recent findings show that some Angiotensin II…