Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with the BioAccord LC-MS System

Application Note CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column Maissa M. Gaye, Chris Knowles, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract The high speed, low cost, and reduced need…

Application Note Head to Tail Analysis of mRNA by RapiZyme™ MC1 and Cusativin Alexandre F. Gomes*, Tatiana Johnston*, Balasubrahmanyam Addepalli * Equal contribution Waters Corporation, United States Published on August 10, 2026 Abstract Head to Tail Analysis of mRNA by…

Application Note Sequence Mapping of mRNA Digests Using the Xevo™ MRT Mass Spectrometer and waters_connect™ MAP Sequence 2.0 Application Catalin Doneanu, Alexandre F. Gomes, Chris Preston, Matt Gorton, Tatiana Johnston, Bala Addepalli, Ying Qing Yu Waters Corporation, United States Published…

Application Note Analysis of mRNA Cap Impurity Profiles and Capping Efficiency Using RapiZyme™ MC1 Ribonuclease Balasubrahmanyam Addepalli, Tatiana Johnston, Catalin Doneanu, Jamuna Vaishnav, Alexandre Gomes, Christian Reidy, Ying Qing Yu, Matthew A. Lauber Waters Corporation, United States Published on June…