Improving Drug Metabolite Identification in Biofluids with the ACQUITY PREMIER and Hybrid Organic Surface Technology: Increased Sensitivity and Reproducibility

MaxPeak Premier Columns Small Molecule Application Notebook CONTENTS Introduction Non-Specific Adsorption: Unwanted Interactions................................................................................... 3 How Do Scientists Solve This Problem Today?......................................................................................... 4 Precision Chemistry for Particles and Surfaces........................................................................................ 5 Fundamentals Waters™ Premier Standards to Investigate the Inertness of Chromatographic Systems....................................................................................................................................7…

Application Note A Rapid UPLC™-MS/MS Method for the Quantification of PROTACs-3-Gefitinib and Urinary Metabolites Following Subcutaneous Administration to Male Rats Robert S. Plumb, Nikunj Tanna Waters Corporation Abstract Proteolysis Targeting Chimera (PROTAC) drugs are now well established in pharmaceutical development…

Application Note Rapid, High Sensitivity Quantification of a Proteolysis Targeting Chimera, PROTAC, in Rat Plasma From a Microsampling DMPK Study Using UPLC-MS/MS Robert S. Plumb Waters Corporation Abstract Proteolysis targeting chimeras are bifunctional molecules with two molecular entities connected by…

Application Note Rapid Identification of the In Vivo Biotransformations of a Targeted Protein Degrader (PROTACs) Using Xevo G3 QTof and waters_connect Software Platform Robert S. Plumb Waters Corporation, United States Published on June 05, 2025 Contact Sales Abstract PROteolysis TArgeting…