Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody Reference Standard with Waters UNIFI Scientific Information System

[ APPLICATION NOTE ] High-Performance Vion IMS QTof for Monoclonal Antibody Intact and Subunit Mass Analysis Henry Shion and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Minimal tuning effort for intact protein Biotherapeutic protein products,…

[ APPLICATION NOTE ] An Integrated LC-MS Platform for Multi-Attribute Monitoring of CQA’s of mAbs at the Subunit Level Nilini Ranbaduge, Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Streamlined workflows…

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…

APPLICATION NOTE 72358 Quick screening of intact antibody and antibodydrug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry Authors Chien-Hsun Alex Chen,1 Stephane Houel,1 Terry Zhang,1 Brian J. Agnew,2 Shanhua Lin,3 Kai Zhou,1 Jonathan Josephs,1 Aran Paulus,1 and Andreas…