High Throughput Screening and Characterization of Bispecifics Using Native Ion Mobility Mass Spectrometry

High Resolution Mass Spectrometry of Antibody Drug Conjugates Using the Orbitrap Mass Analyzer Kai Scheffler1, Eugen Damoc2, Aaron Bailey3, and Jonathan Josephs3 Thermo Fisher Scientific, 1Dreieich, Germany, 2Bremen, Germany, 3San Jose, USA Figure 1: Operating modes for the three major…

CUSTOMER APPLICATION NOTE 73898 Seamless LC-MS method transfer in a biopharmaceutical development laboratory Authors: Dan Bach Kristensen1, Trine Meiborg Sloth1, Martin Ørgaard1, Pernille Foged Jensen1, Krisztina Radi2 Symphogen, Ballerup, Denmark 1 Thermo Fisher Scientific, Hemel Hempstead, UK 2 Keywords: Native…

APPLICATION BRIEF 73554 Sensitive profiling of IgG1 monoclonal antibody variants under native conditions Authors: Sara Carillo and Jonathan Bones NIBRT – The National Institute for Bioprocessing Research and Training, Dublin, Ireland [email protected] Keywords: Monoclonal antibody, native MS, mass spectrometry, biopharma,…

APPLICATION NOTE 21880 Comparing biosimilars using intact mass analysis under denaturing and native conditions Authors Sara Carillo, Izabela Zaborowska, Jonathan Bones National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland Keywords NIBRT, biopharmaceutical, biotherapeutic, monoclonal antibody (mAb), IgG, biosimilar,…