In the week from September 21, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 6 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Malvern Panalytical: Unlocking the Solid Form: XRD Solutions for Pharmaceutical Development and Manufacturing</h5><ul><li>Tu, 22.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6555">Registration</a></li></ul>Discover how X-ray diffraction (XRD) supports pharmaceutical development by characterizing polymorphism, crystal structure, crystallinity, and amorphous content from API development to QC.<h5>2. Bruker: XFlash® FlatQUAD 2L: Step Into The Future of SEM Elemental Analysis</h5><ul><li>Tu, 22.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6516">Registration</a></li></ul>Discover a new detector for SEM elemental analysis and learn how XFlash® FlatQUAD 2L can accelerate elemental analysis and imaging of sensitive samples.<h5>3. Malvern Panalytical: Future Days: Catalysts, What Will Define the Next Decade of Catalysis?</h5><ul><li>Tu, 22.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6553">Registration</a></li></ul>Explore the future of catalysis in hydrogen, CCUS, sustainable chemicals, and circular manufacturing, with expert insights on markets, standards, catalyst development, and advanced characterization.<h5>4. Bruker: Probing Structure, Ion Dynamics and Interfacial Reactivity in Energy-Storage Materials by Solid-State NMR</h5><ul><li>Tu, 22.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6515">Registration</a></li></ul>Learn how solid-state NMR reveals local structure, ion dynamics, and SEI interfacial behavior in energy-storage materials.<h5>5. Agilent Technologies: How to Perform Routine Quantification by FTIR: Tips &amp; Tricks Workshop</h5><ul><li>Tu, 22.9.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6442">Registration</a></li></ul>Master routine FTIR quantification in this hands-on workshop. Learn how to use MicroLab and MicroLab Quant software to measure standards, build calibration curves, and analyze real-world samples.<h5>6. Agilent Technologies: Learn How FTIR Can Help You with Contamination and Poor Product Quality</h5><ul><li>Tu, 22.9.2026 21:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6441">Registration</a></li></ul>Discover how Agilent portable FTIR spectrometers enable fast, cost-effective contamination analysis with versatile sampling options to address product quality and equipment issues.<h5>7. Bruker: From Cleared Tissue to Quantitative 3D Insights: Integrated Bruker and Translucence Biosystems Workflows for Whole-Organ Imaging</h5><ul><li>We, 23.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6544">Registration</a></li></ul>Discover integrated Bruker and Translucence Biosystems workflows for 3D cleared tissue imaging and quantitative whole-organ light-sheet microscopy.<h5>8. SPECTRO Analytical Instruments: Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation</h5><ul><li>Th, 24.9.2026 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6527">Registration</a></li></ul>Learn how automated ICP-OES analysis of lubricating oils can accelerate quality control and wear metal monitoring workflows using SPECTRO GENESIS DSOI and ACAROS automation.<h5>9. Agilent Technologies: Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope</h5><ul><li>Th, 24.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6540">Registration</a></li></ul>Discover how the Agilent LDIR 8700 uses QCL-based infrared imaging to automate rapid microplastics analysis, data processing, and reporting while supporting current standards.<h5>10. Malvern Panalytical: From Sample to Reliable Result: How to Optimise Particle Concentration Measurements on the Zetasizer Advance</h5><ul><li>Th, 24.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6557">Registration</a></li></ul>Learn how to optimize particle concentration measurements with the Zetasizer Advance, from sample preparation and parameter selection to data-quality checks and improved repeatability.<h5>11. Wiley: Image, analyze, and fabricate at the nanoscale: Advances in SEM and FIB SEM for quantum materials research</h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6524">Registration</a></li></ul>Explore advances in SEM and FIB-SEM for quantum materials research and learn how these technologies support 3D characterization, nanoscale analysis, and nanodevice fabrication.<h5>12. Mettler-Toledo: Thermal Analysis of Thermoset Materials</h5><ul><li>Th, 24.9.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/5777">Registration</a></li></ul>Explore the most important thermal properties of thermoset materials and learn how thermal analysis techniques can be used for their characterization.<h5>13. Agilent Technologies: Why fast, reliable trace-element analysis starts with triple-quad ICP-MS</h5><ul><li>Fr, 25.9.2026 17:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6547">Registration</a></li></ul>Discover how the Agilent 9500 triple-quadrupole ICP-MS accelerates trace-element analysis and helps eliminate spectral interferences for reliable results.

Webinars LabRulezICPMS Week 39/2026

Combining elemental analysis and molecular techniques to characterize Ancient Egyptian mummification balms

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, LECO and Shimadzu and technical note by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</h3>Fast, accurate AOAC compliant food analysis using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> with AVS MS and ADS 2&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf">Full PDF for download</a>&nbsp;</li></ul>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.<h4>Conclusion&nbsp;</h4>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;<ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.<h3>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf">Full PDF for download</a></li></ul>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.<h4>Instrument Model and Configuration&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883">LECO C832</a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO2.<h4>Typical Results&nbsp;</h4>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.<h3>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050">Shimadzu ICPMS-2050</a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.<h4>Conclusion</h4>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.<h3>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf">Full PDF for download</a></li></ul>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992">Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</a> (shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;<ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

Article

Webinars

Application

Scientific article

Science and research

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

BÜCHI

The Analytical Scientist

Agilent Technologies

Unchained Labs

Thermo Fisher Scientific

SelectScience

Shimadzu Corporation

The presentation will introduce DiscovIR-GC® (FTIR) as a universal detector that can be coupled with any Gas Chromatograph, using solid-phase direct deposition to afford unique molecule fingerprinting, while boosting the resolution and sensitivity over conventional gas phase devices.
FTIR is a powerful tool for the identification of specific isomers of controlled substances and when integrated with MS, accuracy of identification is superior. By joining the strengths of the FTIR and MS detectors, the characterization of unknowns is easily performed in a single analysis. FTIR allows for spectral distinction between positional isomers where identification by MS is limited.
As a walk-up instrument, the DiscovIR-GC system is designed to meet the needs of forensic drug chemistry laboratories and make use of spectral databases for rapid and accurate identification of unknowns through the orthogonal information gathered from FTIR.
Learning Objectives of Webinar:
<ul>
<li>Understand the technology behind solid-phase deposition FTIR coupled with GC</li>
<li>Gain insight into the differences between gas phase IR and solid-phase IR spectroscopy</li>
<li>Understand the capability for identification of synthetic opioids based on structural differences in IR finger printing</li>
</ul>
<blockquote>
Presenter: Nathan Hawkins (CEO, Spectrometrics Limited)
</blockquote>
<blockquote>
Nathan is the CEO of Spectrometrics, UK. He managed a metabolomics core facility for 14 years, before moving into a hybrid commercial role that included account and product management of a small instrument vendor’s portfolio of life science &amp; forensics instruments.
</blockquote>
<blockquote>
He established Spectrometrics in 2022 to bring new &amp; emerging analytical technologies to the UK &amp; Ireland.
</blockquote>
<blockquote>
Presenter: Tracy Phillpott (Senior Applications Chemist,, Spectra Analysis Instruments, Inc.)
</blockquote>
<blockquote>
Tracy Phillpott is the Senior Applications Chemist with Spectra Analysis Instruments, USA. She has a Bachelor’s in Textile Chemistry from Auburn University. Her previous experience has been in the Textile, Polymer, Tire, and Pharma Industries for Morton International, Michelin Americas R&amp;D, Schweizerhall Development Company and IRIX Pharmaceuticals.
</blockquote>

The Analytical Scientist: DiscovIR-GC® Detector: Integration of GC-FTIR and MS as a Unique Tool in the Identification of Positional and Structural Isomers

DiscovIR-GC Detector: Integration of GC-FTIR and MS as a Unique Tool in the Identification of Positional and Structural Isomers

The presentation will introduce DiscovIR-GC (FTIR) as a universal detector that can be coupled with any Gas Chromatograph.

DiscovIR-GC Detector: Integration of GC-FTIR and MS

The speed of NIR spectroscopy in analyzing a vast range of analytes can streamline several processes in the food and feed industry. Rapid analysis can improve productivity and reduce quality control and development costs. Results can be gained in seconds as opposed to hours.
During the webinar find out:
<ul>
<li>What is a Calibration and why do we need to develop them?</li>
<li>Is it possible to calibrate any parameter?</li>
<li>What are the steps I need to follow for calibration development?</li>
<li>How many samples do I need and how do I select them?</li>
<li>How can we judge the performance of a calibration?</li>
</ul>
and many more...
<blockquote>
Presenter: Marko Stojkovic (Head of NIR Training and Education, Büchi Labortechnik AG)
</blockquote>
<blockquote>
After finishing his studies in Pharmaceutical Sciences and PhD in Analytical Sciences, he has joined BUCHI for almost a decade now, applying the knowledge acquired over the years.
</blockquote>
<blockquote>
Presenter: Estefania Perez Fernandez (Application Specialist NIR, Büchi Labortechnik AG)
</blockquote>
<blockquote>
I first joined the NIR world during my pre- and post-doctoral research studies. I joined the NIR group at BUCHI six years ago, and overall I accumulate over 15 years of experience with the NIR technology. Time flies when you work with NIR!
</blockquote>
<blockquote>
Presenter: Eduard Wiedenbeck
</blockquote>
<blockquote>
Dr. Eduard Wiedenbeck holds a PhD in chemistry from the University of Konstanz, Germany. His pre- and post-doctoral research projects have focused on analytical chemistry including techniques for protein determination. He joined BUCHI Labortechnik AG in 2020 as a Product Specialist.
</blockquote>
<blockquote>
Presenter: Maren Sander (Product Manager Extraction and Parallel Evaporation, Büchi Labortechnik AG)
</blockquote>
<blockquote>
Mrs. Maren Sander received her Diploma in Physical Chemistry from University of Oldenburg, Germany. She joined BUCHI Labortechnik 15 years ago, first as an application chemist and currently as product manager for pressurized solvent extraction and parallel evaporation.
</blockquote>
<blockquote>
Presenter: Branko Vranic (Head of Application Development, Business Area NIR, Büchi Labortechnik AG)
</blockquote>
<blockquote>
Mr. Branko Vranic obtained his PhD in Pharmaceutical Technology and Industrial Pharmacy at the University of Basel, Switzerland. He joined BUCHI 12 years ago as Application and Training Specialist NIR and is currently head of NIR application development team.
</blockquote>
<blockquote>
Presenter: Sonja König (Product Specialist NIR, Büchi Labortechnik AG)
</blockquote>
<blockquote>
Dr. Sonja König holds a PhD in Chemistry from University of Tübingen, Germany. She has gained experience with diverse analytical methods during her career. Since 2019, she is working for Büchi Labortechnik AG as a Specialist in the field of NIR analyses.
</blockquote>

Büchi: All you need to know for successful NIR calibration development

All you need to know for successful NIR calibration development

Rapid NIR analysis can improve productivity and reduce quality control and development costs. Results can be gained in seconds as opposed to hours.

Successful NIR calibration development

Join us for our next webinar and learn more about simplified testing of pharmaceutical products using FTIR and corresponding accessories as well as software features. Find out more about challenges involved and how we can use FTIR for this application.
The webinar will cover:
<ul>
<li>The importance of pharmaceutical testing</li>
<li>Introduction to FTIR</li>
<li>Step-by-step simplified software workflows</li>
<li>Typical accessories used in pharmaceutical testing</li>
</ul>

Shimadzu: Simplified Analysis of Pharmaceutical Products Using FTIR

Simplified Analysis of Pharmaceutical Products Using FTIR

Simplified testing of pharmaceutical products using FTIR and corresponding accessories as well as software features.

Human shelterin is a six-subunit complex that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA.
Although high-resolution structures have been generated for individual structured domains of shelterin subunits, the structure and stoichiometry of the full complex is unknown.
In this webinar, Dr. John Zinder, a Senior Scientist in the Structural Biology group at Odyssey Therapeutics, will discuss the purification of shelterin subcomplexes and reconstitution of the entire complex using full-length, recombinant subunits. By combining mass photometry, negative-stain electron microscopy (EM), crosslinking mass spectrometry (XLMS), AlphaFold modelling, and native mass spectrometry (MS), stoichiometries were obtained, as well as domain-scale architectures of shelterin subcomplexes.
In addition, Dr. Zinder will present data on shelterin complexes which feature extensive conformational heterogeneity, regardless of the presence of DNA substrates. He will also explain how shelterin adopts a multitude of conformations and its unusually high structural variability can be beneficial for its many functions at telomeres.
Key learning objectives
<ul>
<li>Learn how to study conformational heterogeneity using single-particle mass analysis, including mass photometry</li>
<li>Understand how modelling can aid in the characterization of highly flexible assemblies, such as shelterin</li>
<li>Discover how mass photometry, especially when combined with complementary techniques, can be a powerful tool for determining the stoichiometry of a complex as well as its compositional heterogeneity at low concentrations</li>
</ul>
Who should attend?
<ul>
<li>Anyone interested in mass photometry, the architecture of shelterin, protein complexes, protein-DNA interactions, telomere stability, structure determination, molecule prediction, homology modeling, and mass spectrometry.</li>
</ul>
<blockquote>
Presenter: Davide Zinder PhD (Odyssey Therapeutics)
</blockquote>
<blockquote>
Dr. John Zinder is a Senior Scientist in the Structural Biology group at Odyssey Therapeutics and works in the development of novel therapeutics. He has an undergraduate degree in Chemistry from Cornell University, and a masters degree in Biochemistry from the University of Colorado. He was awarded a PhD in Chemical Biology from his research in Chris Lima’s lab at the Sloan Kettering Institute. Zinder subsequently became a Damon Runyon Postdoctoral Fellow in the de Lange and Walz labs at the Rockefeller University.
</blockquote>
<blockquote>
Presenter: Lawrence Howes (SelectScience)
</blockquote>
<blockquote>
Lawrence studied biological sciences at Swansea University, UK, before completing a master’s in epidemiology at the University of Bristol. As a member of the Editorial team, he now plays an integral role in shaping the content on SelectScience
</blockquote>

SelectScience: Architecture and Stoichiometry of Human Shelterin Using Single-Particle EM and Mass Analysis

Architecture and Stoichiometry of Human Shelterin Using Single-Particle EM and Mass Analysis

Purification of shelterin subcomplexes and reconstitution of the entire complex using full-length, recombinant subunits.

Architecture and Stoichiometry of Human Shelterin

Are you spending too much time on method building and post run data analysis? Fear no more! Let the intuitive ICP Expert software do the brainstorming.
Learn how to utilize all the hardware and software features to simplify your pre and post run work.
<blockquote>
Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
</blockquote>

Agilent Technologies: Are Your ICP-OES Results Optimized? Discover how to simplify Method Development and Data Analysis on ICP-OES

Are Your ICP-OES Results Optimized? Discover how to simplify Method Development and Data Analysis on ICP-OES

 Learn how to utilize all the hardware and software features to simplify your pre and post run work.

Method Development and Data Analysis on ICP-OES

Welcome to Thermo Fisher Scientific’s Powering Productivity in Food and Environmental Testing webinar series!
ICP-MS instruments are common inorganic analysis tools for trace elemental analysis in the environmental industry due to their multi-element capability and ability to detect toxic elements below the levels required by regulations.
Instrument performance has evolved with ever more challenging regulations, and to meet requirements for new and emerging applications. However, the challenge of high matrix samples and achieving maximum instrument uptime is still an issue many laboratories face. The new Thermo ScientificTM iCAPTM RQplus ICP-MS and the Thermo Scientific iSC-65 Autosampler have been developed to face these productivity challenges head on.
This presentation highlights the key role that Thermo Scientific iCAP RQplus ICP-MS has in a modern high-throughput regulated environmental laboratory, with robust, automated handling of wide varieties of difficult sample matrices, from water to brines. In addition, the presenters explore the role of the supporting technologies of ICP-OES, and triple quadrupole ICP-MS in environmental analysis.
<blockquote>
Presenter: Jon Peters (Product Marketing Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Jon Peters is a Product Marketing manager with Thermo Fisher Scientific specializing in Trace Elemental Analysis instrumentation. He applies his experience with atomic spectroscopy instrumentation, software, consumables, and sample introduction accessories to creating innovative marketing initiatives.
</blockquote>
<blockquote>
Presenter: Dr. Daniel Kutscher (Product Marketing Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
After graduation in Chemistry in 2007, Daniel obtained his PhD from the University of Oviedo in 2011. In the same year he joined Thermo Fisher Scientific and has had different roles in application development and marketing. Currently, he manages the Application Development for trace elemental analysis and GC/GC-MS products.
</blockquote>

Thermo Scientific: Powering through the complexity of elemental environmental analysis

Powering through the complexity of elemental environmental analysis

The key role that Thermo Scientific iCAP RQplus ICP-MS has in a modern high-throughput regulated environmental laboratory.

The complexity of elemental environmental analysis

Examining powdered samples in the presence of a reactive gas or at elevated temperatures could be a difficult measurement to make.
During this workshop, we will be looking at how to make such diffuse reflection measurements using a high-end Cary instrument and an accessory from Harrick Scientific known as the Praying Mantis. Tips and tricks of using this accessory will also be discussed.
<blockquote>
Presenter: Mark Fisher, PhD (Application Engineer, Molecular Spectroscopy, Agilent Technologies, Inc.)
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<blockquote>
Mark, an Application Scientist for Agilent Technologies, has over 35 years of experience in molecular spectroscopy. He has held roles in Agilent&#39;s UV-Vis-NIR, fluorescence, and atomic absorption product portfolios. In addition to identifying industry trends and new business needs, Mark&#39;s responsibilities include application development, pre and post-sales support, as well as acting as a customer advocate for new product and technology opportunities. Mark received his doctorate in analytical chemistry from the University of Nebraska-Lincoln.
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Presenter: Sue Berets, PhD (Applications Scientist, Harrick Scientific Products)
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Sue, an Applications Chemist for Harrick Scientific Products, has over 30 years of experience in accessories and optics for molecular spectroscopy. Sue received her doctorate in physical chemistry from Tufts University and has carried out basic research in theoretical and applied spectroscopy. Her responsibilities include technical and sales support, including accessing products for specific customer applications. She is involved in new product development, from initial concept to finished product, to meet the every changing applications needs of the market.
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Agilent Technologies: Unique Measurement Capabilities Using the Praying Mantis and a Cary UV-Vis system

Unique Measurement Capabilities Using the Praying Mantis and a Cary UV-Vis system

How to make such diffuse reflection measurements using a high-end Cary instrument and an accessory from Harrick Scientific known as the Praying Mantis.

Using the Praying Mantis and a Cary UV-Vis system

In the world of protein formulations, just one poorly behaved excipient can ruin your day… and your dataset. The wrong excipient can promote unfolding or aggregation, so having a big toolbox handy to test how a formulation behaves can save the day. Uncle’s unique combination of fluorescence, SLS, DLS and wide variety of applications means the right tool for the job is always handy – thermal stability, isothermal experiments, kD &amp; B22, G22 and more. Uncle even has a tool for those unruly excipients that throw a wrench in your data by interfering with your protein’s intrinsic fluorescence. Uncle’s full-spectrum fluorescence detection sees fluorescence issues, lets you diagnose what’s going on and helps you solve the problem by changing up your analysis.&nbsp;This talk will look at the many tools Uncle can use to screen formulations for their impact on protein stability, and how Uncle helps you keep an eye out for any nasty surprises that oddball excipients can throw your way.<blockquote>Presenter:&nbsp;Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.Moderator: Kevin Lance, PhD (Marketing Manager, Analytical Instruments, Unchained Labs)</blockquote>

Unchained Labs: Build up your protein formulation toolbox with Uncle

Build up your protein formulation toolbox with Uncle

Uncle helps spot excipient issues early with tools like fluorescence, SLS, and DLS—keeping your protein formulations stable and your data clean.

<h5>The Problem</h5>Buffer exchange is a critical step to developing optimal vectors and payloads. Compared to biologics, development of delivery vectors like lipid nanoparticles (LNPs) and adeno-associated viruses (AAVs) is a newer research area with different challenges and opportunities to address. LNPs require fast buffer exchange to remove any organic phase without disrupting encapsulation efficiency or causing size change. AAVs usually need concentration after manufacturing in addition to buffer exchange at a high recovery. Both vectors can vary wildly in their manufacturing conditions or serotype, meaning a single solution may not be the best fit.<h5>The Solution</h5>Unagi is a benchtop automated buffer exchange and concentration instrument designed to handle a wide range of biologics and gene therapy biomolecules. Using pressure based ultra-filtration/diafiltration (UF/DF) technology coupled with non-contact individual sample volume measurement, Unagi will deliver precise buffer exchange and concentration targets without putting a dent in your sample recovery. With the ability to parallel process 1-8 samples in a volume range between 0.5 – 48 mL, Unagi can help with screening, formulation, quality control, and analytical prep workflows. Programmable settings, including the optional orbital mixing, can be used with default settings, or customized to your unique nucleic acid, AAV, and LNP samples.<h5>The Proof</h5>Join us to see firsthand data results demonstrating the power and flexibility of Unagi for nucleic acids, LNPs, and AAVs. Final exchange and concentration values, along with analytic characterization, will be shown under different conditions.<blockquote>Presenter:&nbsp;Del Ray Jackson (Market Manager, Buffer Exchange &amp; Automation, Unchained Labs)Moderator: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.</blockquote>

Unchained Labs: Power up your LNP & AAV sample prep with Unagi

Power up your LNP & AAV sample prep with Unagi

Join us to see firsthand data results demonstrating the power and flexibility of Unagi for nucleic acids, LNPs, and AAVs. 

<h5>The Problem</h5>Manual buffer exchange methods take up tons of your precious time and are a pain to manage in large numbers - often leaving you with inconsistent results and playing catch up to meet your deadlines.<h5>The Solution</h5>Big Tuna is a fully automated buffer exchange platform that can exchange and concentrate up to 96 samples in parallel – with just 30 minutes of setup. By automating the previously painful and error prone process of buffer exchange and concentration, Big Tuna gives researchers the consistent sample handling, degrees of process control and throughput that just aren’t possible with manual methods.<h5>The Proof</h5>Tune in to learn how Big Tuna has helped tons of labs and CDMOs smash their buffer exchange bottlenecks for proteins, mAbs, nucleic acids, AAVs and LNPs. We will show formulation case studies for both mAbs and AAVs that will showcase the type of real recovery results of less than 96% you can expect from automating your buffer exchange with Big Tuna.<blockquote>Presenter:&nbsp;Del Ray Jackson (Market Manager, Buffer Exchange &amp; Automation, Unchained Labs)Moderator: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.</blockquote>

Unchained Labs: Chuck the buffer exchange time suck with Big Tuna

Chuck the buffer exchange time suck with Big Tuna

Tired of manual buffer exchange? Learn how Big Tuna automates up to 96 samples, saving time and boosting consistency for proteins, mAbs, AAVs, and more.