Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 14th September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you technical note by Agilent Technologies, application notes by Metrohm and Thermo Fisher Scientific and poster by Shimadzu / AOAC!<h3>1. Agilent Technologies: Transitioning from the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=Cary+630">Agilent Cary 630 FTIR</a> to the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=Cary+635">Agilent Cary 635 FTIR Spectrometer</a></h3>Demonstrating methodology equivalence for pharmaceutical applications<ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/te_cary_630_ftir_transition_cary_635_ftir_5994_9408en_agilent_a2ea2ce512.pdf">Full PDF for download</a>&nbsp;</li></ul>Fourier transform infrared (FTIR) spectroscopy is a powerful analytical tool used to analyze a wide variety of materials by interpreting their infrared (IR) wavenumber absorptions. Within pharmaceutical and biopharmaceutical industries, FTIR analysis is integral for material identification and quality assurance of pharmaceutical&nbsp;substances.&nbsp;In the pharmaceutical industry, the Agilent Cary 630 FTIR is used for the identification of drug products, incoming goods, and packaging materials, as specified in global pharmacopoeias, and provides quantitative information such as the concentration of components within pharmaceutical formulations.&nbsp;Agilent now presents the Cary 635 FTIR spectrometer—an ultracompact, easy-to-use, high-performing, portable FTIR system. With greater IR power, the Cary 635 FTIR features greater detection sensitivity and faster scanning times. With its predecessor's modular design, the Cary 635 FTIR can analyze the same samples with a newly enhanced performance quality and efficiency.&nbsp;For users in the pharmaceutical industry who have experience with the Cary 630 FTIR, this technical overview demonstrates the common methodologies and workflows between the Cary 635 FTIR and Cary 630 FTIR spectrometers for pharmaceutical purposes. It will compare the ability of the two instruments to measure and label IR spectra, identify relevant compounds such as active pharmaceutical ingredients (APIs), and quantify substances within commercial&nbsp;formulations.<h4>Instrumentation and software&nbsp;</h4>For comparison, all three application tests were conducted using the Cary 630 FTIR and Cary 635 FTIR spectrometers with ZnSe optics and equipped with a single-reflection diamond attenuated total reflectance (ATR) accessory. The specific method parameters are outlined within each corresponding application. Both the Cary 635 FTIR and Cary 630 FTIR use Agilent MicroLab software, which provides step-by-step instructions with supporting images to guide users through the entire analytical workflow. Both spectrometers follow the same methods and operational procedures from sample loading to data processing (Figure 1). Results are presented in an easy-to-understand, color-coded format with customizable limits, ensuring a rapid and intuitive data review.<h4>Conclusion&nbsp;</h4>The comparison presented here of both the Agilent Cary 635 FTIR and Cary 630 FTIR spectrometers demonstrated shared methodologies that produced consistent results across key applications within pharmacopoeia, including spectrum production, compound identification, and substance&nbsp;quantification. Featuring the same modularity, robustness, and ease of use as the Cary 630 FTIR, the Cary 635 FTIR also offers greater sensitivity and signal-to-noise ratio, resulting from an enhanced IR source intensity. Therefore, users operating in regulated environments can confidently upgrade to the Cary 635 FTIR with the understanding that the workflow from the Cary 630 FTIR is directly transferrable, and that their routine analyses will remain consistent and reliable.<h3>2. Metrohm: Coconut water analysis by NIRS</h3>Determination of Brix, salinity, conductivity, and pH with one instrument<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_nir_145_download_05589da42d.pdf">Full PDF for download</a></li></ul>Fresh coconut water is the main edible part of the coconut (aside from the coconut meat) and has gained popularity as a health drink in recent years. Multiple factors influence the quality, such as harvesting time, growth location, and storage duration. This poses a challenge for industrial producers to achieve and maintain the desired product quality.&nbsp;Testing the properties of coconut water with standard laboratory methods can be challenging, since trained lab personnel are needed. In contrast, near-infrared spectroscopy (NIRS) is fast, chemical-free, and does not require sample preparation. This Application Note explains how NIRS is used for the multiparameter analysis of coconut water. The NIRS solution is easy to use and can be implemented either atline or in a quality control lab.<h4>EXPERIMENTAL EQUIPMENT&nbsp;</h4>An <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=220&amp;search=OMNIS+NIR">OMNIS NIR Analyzer </a>Liquid with a 1 mm flowthrough cell (Figure 1) was used to analyze 206 coconut samples from a commercial supplier. In this configuration, a peristaltic pump injects the sample into the flow-through cell, which is inserted into the cuvette holder. The cell is rinsed with water after each measurement.<h4>CONCLUSION</h4>This Application Note shows the feasibility of using NIR spectroscopy for the quality control of coconut water. The parameters Brix, conductivity, turbidity, pH value, and salinity can be monitored by NIRS in seconds without any sample preparation. The presented setup with a flow-through cell not only simplifies sample handling but also allows full automation when using an OMNIS Sample Robot. In addition to coconut water, the coconut fruit itself can also be analyzed using near-infrared spectroscopy.<h3>3. Shimadzu / AOAC: Analysis of Heavy Metals in Baby Food Using ICP-MS</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_46_d9c14b32e0.pdf">Full PDF for download</a></li></ul>Babies are more vulnerable to the effects of toxic metals, and baby food therefore requires careful testing. US and EU regulations1)–3) set limits for toxic metals in baby food. This study analyzed five baby foods using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=ICPMS-2040%2F2050">ICPMS-2040/2050</a> and evaluated spike recovery and long-term stability.<h4>Conclusion&nbsp;</h4>Elemental analysis of baby food was conducted using ICP-MS.&nbsp;We achieved detection limits that met stringent standards. The spike recovery tests provided good results for all samples with different matrices, confirming the validity of the analysis. Additionally, we analyzed 50 samples of infant formula with a high matrix approximately six hours and confirmed good stability.<h3>4. Thermo Fisher Scientific: Process Raman as a comprehensive solution for downstream buffer workflow</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/process_raman_as_comprehensive_solution_an1440_en_c8049b8ede.pdf">Full PDF for download</a></li></ul>Raman technology is rapidly gaining interest as a promising Process Analytical Technology (PAT) solution for real-time, non-invasive monitoring and control of downstream biopharma processes, especially for therapeutics like monoclonal antibodies (mAbs) and nucleic acids. Raman measurement, based on the vibration of molecular bonds, is highly specific for identification and quantification, even in complex or interfering matrices.&nbsp;As an in-line PAT tool, Raman spectroscopy offers direct and rapid measurement in aqueous phases without sample preparation. These features make it ideal for monitoring and controlling dynamic processes such as downstream processing.This study demonstrates a real-time methodology for accurately quantifying formulation excipients in the dynamic ultrafiltration/diafiltration (UF/DF) process using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2233">Thermo Scientific™ MarqMetrix™ All-In-One Process Raman Analyzer</a> (Figure 1). In addition, this study also illustrates a case where process Raman was able to provide real-time information on buffer quality.<h4>Results&nbsp;</h4>The Partial Least Squares (PLS) models for L-histidine, L-arginine, and sucrose were initially tested using seven independent samples collected on three different process Raman analyzers. Data were mathematically processed to standardize spectra across instruments before applying the models. All the spectra were interpolated to have a common x-axis by equally spacing the 2048 pixels across 60 to 3250 cm-1 Raman shift, followed by relative y-axis standardization using the SRM fluorescence data as described in the NIST standardization protocol.² Figure&nbsp;3 shows the correlation plot of predicted versus reference values for L-histidine, L-arginine, and sucrose for the validation samples. A correlation coefficient of over 95% and a root means square error (RMSE) of less than 5% of the reference value for calibration, cross-validation, and prediction across three instruments demonstrate the reliability of process Raman to accurately predict the concentrations of these excipients, as well as easy model transferability.<h4>Conclusion</h4>This work, combined with our previous demonstrations of accurate in-line protein quantification during UF/DF processes,⁷, ⁸ clearly highlights the value of process Raman for downstream process monitoring. Raman spectroscopy allows for the simultaneous measurement of multiple critical process parameters (CPPs) with a single scan. These findings establish process Raman as a PAT tool with unparalleled benefits compared to other analytical methods.&nbsp;Simultaneous measurement of protein and excipient concentrations not only allows tighter process control but also opens opportunities for automating downstream processing.&nbsp;The ability of process Raman to provide real-time insights into buffer quality before its use in UF/DF runs offers substantial value by preventing batch failures. This capability enhances quality control, making Raman spectroscopy an essential tool for integration as an in-line sensor to improve downstream process monitoring, control, and automation.

News from LabRulezICPMS Library - Week 38, 2026

In the week from September 21, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 6 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Malvern Panalytical: Unlocking the Solid Form: XRD Solutions for Pharmaceutical Development and Manufacturing</h5><ul><li>Tu, 22.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6555">Registration</a></li></ul>Discover how X-ray diffraction (XRD) supports pharmaceutical development by characterizing polymorphism, crystal structure, crystallinity, and amorphous content from API development to QC.<h5>2. Bruker: XFlash® FlatQUAD 2L: Step Into The Future of SEM Elemental Analysis</h5><ul><li>Tu, 22.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6516">Registration</a></li></ul>Discover a new detector for SEM elemental analysis and learn how XFlash® FlatQUAD 2L can accelerate elemental analysis and imaging of sensitive samples.<h5>3. Malvern Panalytical: Future Days: Catalysts, What Will Define the Next Decade of Catalysis?</h5><ul><li>Tu, 22.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6553">Registration</a></li></ul>Explore the future of catalysis in hydrogen, CCUS, sustainable chemicals, and circular manufacturing, with expert insights on markets, standards, catalyst development, and advanced characterization.<h5>4. Bruker: Probing Structure, Ion Dynamics and Interfacial Reactivity in Energy-Storage Materials by Solid-State NMR</h5><ul><li>Tu, 22.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6515">Registration</a></li></ul>Learn how solid-state NMR reveals local structure, ion dynamics, and SEI interfacial behavior in energy-storage materials.<h5>5. Agilent Technologies: How to Perform Routine Quantification by FTIR: Tips &amp; Tricks Workshop</h5><ul><li>Tu, 22.9.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6442">Registration</a></li></ul>Master routine FTIR quantification in this hands-on workshop. Learn how to use MicroLab and MicroLab Quant software to measure standards, build calibration curves, and analyze real-world samples.<h5>6. Agilent Technologies: Learn How FTIR Can Help You with Contamination and Poor Product Quality</h5><ul><li>Tu, 22.9.2026 21:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6441">Registration</a></li></ul>Discover how Agilent portable FTIR spectrometers enable fast, cost-effective contamination analysis with versatile sampling options to address product quality and equipment issues.<h5>7. Bruker: From Cleared Tissue to Quantitative 3D Insights: Integrated Bruker and Translucence Biosystems Workflows for Whole-Organ Imaging</h5><ul><li>We, 23.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6544">Registration</a></li></ul>Discover integrated Bruker and Translucence Biosystems workflows for 3D cleared tissue imaging and quantitative whole-organ light-sheet microscopy.<h5>8. SPECTRO Analytical Instruments: Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation</h5><ul><li>Th, 24.9.2026 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6527">Registration</a></li></ul>Learn how automated ICP-OES analysis of lubricating oils can accelerate quality control and wear metal monitoring workflows using SPECTRO GENESIS DSOI and ACAROS automation.<h5>9. Agilent Technologies: Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope</h5><ul><li>Th, 24.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6540">Registration</a></li></ul>Discover how the Agilent LDIR 8700 uses QCL-based infrared imaging to automate rapid microplastics analysis, data processing, and reporting while supporting current standards.<h5>10. Malvern Panalytical: From Sample to Reliable Result: How to Optimise Particle Concentration Measurements on the Zetasizer Advance</h5><ul><li>Th, 24.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6557">Registration</a></li></ul>Learn how to optimize particle concentration measurements with the Zetasizer Advance, from sample preparation and parameter selection to data-quality checks and improved repeatability.<h5>11. Wiley: Image, analyze, and fabricate at the nanoscale: Advances in SEM and FIB SEM for quantum materials research</h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6524">Registration</a></li></ul>Explore advances in SEM and FIB-SEM for quantum materials research and learn how these technologies support 3D characterization, nanoscale analysis, and nanodevice fabrication.<h5>12. Mettler-Toledo: Thermal Analysis of Thermoset Materials</h5><ul><li>Th, 24.9.2026 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/5777">Registration</a></li></ul>Explore the most important thermal properties of thermoset materials and learn how thermal analysis techniques can be used for their characterization.<h5>13. Agilent Technologies: Why fast, reliable trace-element analysis starts with triple-quad ICP-MS</h5><ul><li>Fr, 25.9.2026 17:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6547">Registration</a></li></ul>Discover how the Agilent 9500 triple-quadrupole ICP-MS accelerates trace-element analysis and helps eliminate spectral interferences for reliable results.

Webinars LabRulezICPMS Week 39/2026

Combining elemental analysis and molecular techniques to characterize Ancient Egyptian mummification balms

Article

Webinars

Application

Scientific article

Science and research

Poster

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Separation Science

Mettler-Toledo

Anton Paar

Agilent Technologies

Bruker

Thermo Fisher Scientific

PerkinElmer

C&EN

<ul>
<li>Introduction to inorganic chemistry</li>
<li>Relevant thermal analysis techniques</li>
<li>DSC examples: glass transitions, phase diagrams, and decomposition</li>
<li>Thermo-optical analysis (TOA) examples: polymorphic transitions</li>
<li>TGA and TGA/DSC examples: decomposition, melting, and evolved gas analysis</li>
<li>TMA examples: expansion, solid-solid transitions, and temperature stability</li>
<li>DMA examples: elasticity</li>
</ul>
Inorganic materials, such as metals, ceramics, salts, and minerals, are encountered almost everywhere in our daily life and are used for a multitude of purposes. In particular, many inorganic materials are known for their exceptional heat resistance, making them invaluable in high-temperature applications.
<h4>Important Types of Analysis for Inorganic Materials</h4>
Inorganic materials often exhibit complex thermal behaviors that can be challenging to study. Luckily, thermal analysis provides us with powerful investigative tools. By utilizing techniques such as DSC, thermo-optical analysis, TGA, TMA, and DMA, we can measure behaviors including melting point, phase transitions, and thermal stability. Evolved gas analysis combined with TGA can also provide important information about the products of decomposition.
Join our live webinar and discover how thermal analysis helps to shape our understanding of these fascinating materials. The presentation will conclude with a Q&amp;A, so don’t miss the chance to ask our experts your questions!
<blockquote>
Presenter: Dr. Teresa Dennenwaldt
</blockquote>
<blockquote>
Dr. Teresa Dennenwaldt obtained her PhD in chemistry in 2013 and completed a postdoc at the Ecole Polytechnique Fédérale de Lausanne, Switzerland in the field of electron microscopy and spectroscopy. In 2018, she joined METTLER TOLEDO as an application specialist for Thermal Analysis. In her current position, she expertly uses, teaches, and supports DSC, TGA, TMA, and DMA instruments at the METTLER TOLEDO head office in Switzerland.
</blockquote>

METTLER TOLEDO: Thermal Analysis of Inorganic Materials

Thermal Analysis of Inorganic Materials

Discover Key Techniques for Characterizing This Diverse Group of Materials

Inflammation plays a pivotal role in the body’s defence against pathogens.
It is part of a cascade of events that are crucial for maintaining organ and systemic homeostasis. While acute inflammatory responses are essential for combating infections, chronic inflammation is increasingly linked to the onset of various clinical conditions, including diabetes, atherosclerosis, cardiometabolic diseases, rheumatoid arthritis, and obesity.
Traditionally, C-Reactive Protein (CRP) has been the gold standard for assessing inflammation. However, recent studies highlight the importance of glycoproteins and lipoproteins in both acute and chronic inflammation. Notably, inflammation can alter the composition and influence the pro- or anti-inflammatory behaviour of HDL particles.
In this webinar, we will explore how Nuclear Magnetic Resonance (NMR*) technology provides robust, fine-grained measurements of glycoproteins and lipoproteins, offering a comprehensive inflammatory profile within minutes. Further, we will present how those models were translated to benchtop NMR spectrometers potentially revolutionizing the landscape of NMR lipoprotein measurements.
Join us for this insightful webinar and discover how our translational achievements in NMR technology are poised to revolutionize clinical research settings.
Key Highlights
<ul>
<li>Innovative NMR Techniques: Learn about our diffusion and relaxation-edited NMR experiments, which led to a model-free inflammatory panel featuring SPC1, SPC2, SPC3, GlycA, and GlycB peaks.
</li>
<li>Comprehensive Data Analysis: Discover how these five parameters enable the construction of a molecular multivariate map of acute and chronic inflammatory phenotypes across multiple disease and population cohorts (N = 5000).
</li>
<li>Translational Technology: Understand the potential of benchtop NMR spectrometers for predicting lipoprotein parameters and fractions.
</li>
<li>Clinical Research Applications: Learn how self-administered capillary blood samples can eliminate the need for venipuncture, opening new avenues for sampling in remote areas or for high-frequency longitudinal studies.
</li>
</ul>
Benefits of Attending
<ul>
<li>Gain insights into the latest advancements in inflammation disease research and NMR * technology.
</li>
<li>Learn how benchtop NMR could bring us closer to routine application.
</li>
<li>Explore the future of inflammation analysis with non-invasive, rapid, and accurate methods.
</li>
</ul>
Who Should Attend?
<ul>
<li>Clinical researchers: Biologists, biochemists, and analytical scientists investigating or interested in expanding research into acute and chronic inflammation linked to the onset of cardiovascular disorders, metabolic syndrome, and related fields.
</li>
<li>Scientists working in human metabolomics research seeking to expand their expertise into standardized NMR-based Metabolomics.
</li>
<li>Graduate students and postdoctoral fellows: Those seeking advanced knowledge and practical skills in applying NMR in human health and inflammation disease.
</li>
<li>Industry professionals: Scientists and R&amp;D personnel in pharmaceutical, biotechnology, and nutritional companies doing research and developing therapeutic and diagnostic solutions related to inflammation
</li>
</ul>
<blockquote>
Presenter: Julien Wist (Professor of Computational Spectroscopy | Deputy Director of the Center for Computational &amp; Systems Medicine)
</blockquote>
<blockquote>
Prof. Julien Wist is currently the Deputy Director of the Centre for Computational and Systems Medicine at Murdoch University and head of operations and lead of the bio-/ chem-informatics team at the Australian National Phenome Centre consisting of software engineers, biostatisticians, chemometricians and data processing experts to develop analytical pipelines for metabolic phenotyping. Wist is involved in international initiative for the development of open-source data analysis and visualisation platforms such as nmrdb.org, nmrium.org and cheminfo.org. 
</blockquote>
<blockquote>
His research focuses on the integration of high-fidelity molecular phenotypes to create translatable methods for the clinical environment. He strives to establish a comprehensive phenotypic databank of the world population by integrating cellular, immunological, and molecular data. Prof. Wist&#39;s research on SARS-CoV-2 infection revealed crucial markers for disease progression, including the acute phase, risk of death, and post-acute COVID 19 syndrome. More recently, Wist and his team detected and elucidated the structure of 10 new molecules for the first time in human urine and elucidated 10 of them, revealing the existence of an extended RSAD2 dependant natural antiviral pathway extending involving the Viperin enzyme to convert CTP into ddhCTP and analogs. These significant findings have led to the filing of 2 patents in collaboration with industry leaders and have been published in renowned international journals.
</blockquote>

Bruker: From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response

From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response

How our translational achievements in NMR technology are poised to revolutionize clinical research settings.

From Biological Exploration to Clinical Translation

Hypoxia occurs due to inadequate oxygen supply and greatly influences solid tumor development and resistance to treatment.
The tumor microenvironment can influence how aggressive a tumor is and correlate with underlying treatment resistance. Microenvironment biomarkers like tumor pH, hypoxia, and angiogenesis have been correlated with cancer aggression and patient outcomes. PET can play a critical role in the diagnosis, treatment orientation, and subsequent management of tumors as it can provide complementary information regarding tumor metabolic properties, particularly when performed simultaneously with advanced MRI techniques. 
Breast cancer is widely known for its high degree of intratumoral heterogeneity, induced by varying selective pressures from the hypoxic tumor microenvironment. In-depth characterization of hypoxia-induced physiological differences between breast cancer subtypes by simultaneous multiparametric PET/MRI would greatly benefit diagnosis and treatment planning in the clinic.
The purpose of this webinar is to discuss challenges in the establishment of MRI protocols, combining, e.g., a) dynamic contrast-enhanced (DCE) and intravoxel incoherent motion (IVIM) MRI for the assessment of intratumoral vascularization, b) hyperoxic blood oxygen level-dependent (BOLD) MRI for the quantification of oxygen delivery, and c) [18F]FMISO PET, highlighting hypoxic tumor subregions.
Finally, we will demonstrate how a combined analysis of simultaneous multiparametric PET/MRI-derived imaging parameters enables the identification of spatially defined and physiologically distinct intratumoral niches within the hypoxic tumor microenvironment. This characterization provides an existing novel perspective on breast cancer and opens up new targets for BC therapy.
What To Expect
<ul>
<li>In the context of a preclinical breast cancer model, a discussion on PET/MRI procedures and challenges to establish protocols that combine DCE and intravoxel incoherent motion for the assessment of intratumoral vascularization, hyperoxic BOLD for the quantification of oxygen delivery and [18F]FMISO PET.</li>
</ul>
Key Learning Topics
<ul>
<li>Simultaneous PET/MRI characterization of hypoxic breast cancer tumor microenvironment
</li>
<li>Intratumoral vascularization
</li>
<li>DCE &amp; BOLD MRI &amp; [18F]FMISO PET
</li>
</ul>
Who should attend?
<ul>
<li>This webinar will be of interest to multiple profiles in the community of biomedical research especially those applying medical imaging techniques in their work. Clinicians, researchers, PhD students, and postdocs as well as laboratory technicians will find this webinar relevant.</li>
</ul>
<blockquote>
Presenter: Silvester J. Bartsch (Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria)
</blockquote>
<blockquote>
Silvester J. Bartsch studied evolutionary biology at the Department of Theoretical Biology, University of Vienna, before he started his PhD-research project at the Department of Biomedical Imaging and Image-guided Therapy and the Medical University of Vienna. His current research aims at the characterization of niches within the hypoxic tumor microenvironment of breast cancer using simultaneous multiparametric PET/MR imaging. To this end, he combines [18F]FDG and [18F]FMISO PET with multiparametric MRI (diffusion-weighted MRI, blood oxygen level dependent MRI, glucose-enhanced CEST-MRI, dynamic contrast enhanced MRI) for the characterization the hypoxia-induced reprogramming of glucose metabolism, as well as the induction of angiogenesis, which are important hallmarks in breast cancer progression.
</blockquote>

Bruker: Hypoxia assessment using simultaneous multiparametric PET/MRI

Hypoxia assessment using simultaneous multiparametric PET/MRI

Simultaneous PET/MRI methods and challenges in the characterization of hypoxia-induced physiological differences between breast cancer subtypes.

Hypoxia assessment using simultaneous multiparametric PET/MR

UV-Vis spectroscopy is a cornerstone analytical technique in the pharmaceutical industry, widely employed for its versatility and reliability serving essential functions such as the synthesis of drug compounds, purity assessment, dissolution profiling, and the analysis of biomolecules throughout the drug development process. This technique is pivotal for ensuring the quality and efficacy of pharmaceutical products. However, the pharmaceutical industry faces several challenges with traditional UV-Vis spectroscopy, such as the need for stringent regulatory compliance, the demand for high precision and accuracy, and the requirement for efficient data management systems to handle the vast amount of data generated.The Agilent Cary 3500 UV-Vis model addresses these pain points effectively, join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.Key Takeaways:<ul><li>Innovative Temperature Control: Learn how the Cary 3500’s precise temperature control accelerates your analytical processes.</li><li>Rapid Data Acquisition: Understand the impact of high-speed data collection on your research outcomes.</li><li>Small-Volume Mastery: Explore the instrument’s proficiency in small-volume analysis, ensuring accuracy down to the minutest quantities.</li><li>Highest Absorbance Range: Explore the Cary 3500’s superior absorbance range for unparalleled sensitivity in your measurements.</li><li>OpenLab Server Connectivity: Experience the seamless data management and integrity that OpenLab server-based connectivity provides, meeting stringent regulatory compliance.</li><li>Interactive Q&amp;A Session: Engage with our experts to address your queries and discuss the instrument’s application in real-world pharmaceutical scenarios.</li></ul><blockquote>Presenter: Ms. Vijaya Jyothi (Product Specialist - Spectroscopy, Agilent Technologies)Vijaya Jyothi is a seasoned product specialist at Agilent Technologies. She manages the spectroscopy division, having extensive expertise in spectroscopy applications across diverse industries, offering deep insights and solutions tailored to varied analytical needs.</blockquote>

Agilent: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity

Discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.

Cary 3500 UV-VIS Advanced Capabilities

Join us for the ICP-MS event of the year where we will explore how to streamline your ICP-MS workflows and enhance your productivity and elemental research using the latest ICP-MS technology.Our team of experts will unveil the most recent advancements in ICP-MS, showcasing how these innovations can simplify your ICP-MS analysis and help you achieve your analysis goals.<h4>During this webinar, you will learn how to:</h4><ul><li>Optimize your ICP-MS workflows for improved efficiency &nbsp;</li><li>Maximize instrument up-time and productivity&nbsp; &nbsp;</li><li>Gain confidence in analysis of high matrix samples &nbsp;</li><li>Approach novel applications with ease and simplicity &nbsp;</li><li>Enhance your research output</li></ul><blockquote>Presenter: Matthew Cassap (Product Marketing Manager - AAS and ICP-OES Trace Elemental Analysis, Thermo Fisher Scientific) Presenter:&nbsp;Daniel Kutscher (Manager Product Application, Trace Elemental Analysis, Thermo Fisher Scientific)</blockquote>

Thermo Scientific: Ignite Your ICP-MS Workflow for Enhanced Efficiency and Productivity

Ignite Your ICP-MS Workflow for Enhanced Efficiency and Productivity

How to streamline your ICP-MS workflows and enhance your productivity and elemental research using the latest ICP-MS technology.

Ignite Your ICP-MS Workflow for Enhanced Efficiency

Join us for an insightful webinar on the sustainable extraction of lithium, a crucial component in the lithium-ion battery supply chain.Learn from industry experts about the advantages of Direct Lithium Extraction (DLE) from mineral-rich brines over traditional hard rock mining methods. Discover how managing elemental impurities is essential for maximizing battery efficiency, yield, and safety. Gain insights into advanced techniques like ICP-OES and the ADS 2 auto-diluter system used to quantify major and minor element concentrations in brine samples and manufacturing chemicals.<h4>By attending this webinar, you will learn about:</h4><ul><li>The latest innovative sustainable lithium extraction techniques using Direct Lithium Extraction (DLE) from mineral-rich brine, a method that is more environmentally friendly and efficient compared to traditional hard rock mining</li><li>How to prepare samples and perform elemental analysis by atomic spectroscopy for complex matrix samples across the lithium-ion battery supply chain</li><li>Enhancing the sustainability, efficiency, and accuracy of your ICP-OES elemental analysis with new automation capability</li></ul><h4>Key Topics</h4><ul><li>Overview of emerging lithium extraction methods, including innovative and eco-friendly processes</li><li>How elemental analysis by atomic spectroscopy guides the optimization in the extraction process</li><li>Learn about sample preparation and ICP-OES analysis of raw materials and manufacturing chemicals in the lithium-ion battery value chain</li></ul><h4>Who Should Attend?</h4><ul><li>Chemical engineers and production engineers working in lithium-rich brine extraction</li><li>Production engineers working with lithium-ion battery cathode and electrolyte component production</li><li>Research scientists working around the lithium-ion battery supply chain.</li><li>Industry consultants advising companies around lithium extraction and battery manufacturing</li><li>Quality assurance and control specialists focusing on improving analytical accuracy</li></ul><blockquote>Presenter:&nbsp;Ross Ashdown (Marketing Manager, Optical Atomic Spectroscopy, Agilent Technologies)Ross has a Master of Applied Science in Analytical Chemistry from RMIT University Australia and has over 32 years of experience in atomic spectroscopy, covering instrument operation, applications support, technical support, product management, and marketing management. Ross is based in Agilent’s Spectroscopy Technology Innovation Centre (S.T.I.C.) in Melbourne, Australia. The STIC is Agilent’s global research and development centre for atomic and molecular spectroscopy.Presenter:&nbsp;Jeremy Patt (Chief Technology Officer, Summit Nanotech)Jeremy Patt is Chief Technology Officer at Summit Nanotech. The company, founded in 2018, is using its patented technology to extract lithium from brines at the lowest levelized cost of production and with the lowest environmental footprint. Jeremy has held numerous global leadership positions in the chemical industry – building and advancing research programs, pilot plants, and first-of-kind manufacturing plants for companies including Dow Chemical and Sherwin Williams. He has led the development and successful commercialization of processes across a broad range of technologies, including high-volume chemical production, catalysis, adsorption, extraction, membranes, filtration, heat exchange, drying, solids handling, and water treatment. Jeremy holds a BSE and PhD in Chemical Engineering, both from the University of Michigan, Ann Arbor. He is an inventor on 18 U.S. patents.Presenter:&nbsp;Ana Gonzalez (Atomic Spectroscopy Application Scientist, Agilent Technologies)Ana is based in Wilmington, Delaware, USA. With a robust background in atomic spectroscopy instruments, Ana boasts international experience in the development and validation of analytical methods tailored for the geochemical industry. Her expertise extends to lithium-ion battery technology, where she has made significant contributions to the comprehensive understanding of lithium brine characterization in South America, as well as the analysis of lithium battery components such as cathodes, anodes, and electrolytes. Ana's proficiency also encompasses molecular spectroscopy and chemometrics, as evidenced by her notable publications in these fields. She holds a Master of Science degree in Plant Biotechnology from CINVESTAV, México, complemented by a Bachelor of Science degree in Biotechnology Engineering. With her diverse skill set and passion for advancing scientific knowledge, Ana continues to drive innovation and excellence in her field.Presenter: Ruby Bradford (Atomic Spectroscopy Application Chemist, Agilent Technologies)Ruby is an application chemist at Agilent Technologies, having worked in the Atomic Spectroscopy Division since 2020. She works frequently on the analysis of fine chemicals using techniques such as inductively coupled plasma-optical emission spectroscopy (ICP-OES) and is experienced in method development and sample preparation techniques in the advanced materials sector. She has a particular passion for the booming lithium-ion battery market and promoting a sustainable future through electrification.</blockquote>

Separation Science: Enhancing Lithium-Ion Battery Production: Automated and Sustainable Elemental Analysis in Mining and Manufacturing using ICP-OES

Enhancing Lithium-Ion Battery Production: Automated and Sustainable Elemental Analysis in Mining and Manufacturing using ICP-OES

Sustainable extraction of lithium, a crucial component in the lithium-ion battery supply chain.

Enhancing Lithium-Ion Battery Production

In this webinar, hear from the Institute of General and Analytical Chemistry research team at Montanuniversität Leoben (MUL) in Austria.&nbsp;Speakers will outline their research work on identifying and quantifying TCEs (Technology Critical Elements) found in electronic waste. These critical elements, essential for modern technology, pose significant recycling challenges but they also create opportunities to drive industrial innovation while promoting a cleaner, safer environment. MUL’s research contributes to EU initiatives such as the EU Green Deal and the Circular Economy Action Plan, aiming to scale up e-waste recycling processes to meet Europe’s sustainability goals. Join the discussion to see how PerkinElmer’s analytical instruments and supporting solutions help to tackle these issues.Whether you're a scientist, researcher, chemical engineer or environmental regulator, we can help you to confidently test the TCEs that are integral to both recycling industries and environmental monitoring.<h4>LEARNING OUTCOMES:</h4><ul><li>Define and understand TCEs (Technology Critical Elements) in the academic and governmental landscape</li><li>Learn about sampling challenges from e-waste sources such as smartphones, batteries and PCBs</li><li>Learn how to identify and measure metal contamination in urban green spaces</li><li>Get an overview of key elemental analysis techniques such as ICP-MS and ICP-OES for field and laboratory work</li><li>Learn novel mass spec methodologies: Nitrous Oxide and Gas Cell Interaction studies</li></ul>

PerkinElmer: Technology Critical Element Extraction: Transforming E-Waste into Environmental and Industrial Opportunities

Technology Critical Element Extraction: Transforming E-Waste into Environmental and Industrial Opportunities

Identifying and quantifying TCEs (Technology Critical Elements) found in electronic waste.

Technology Critical Element Extraction: Transforming E-Waste

The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines, posing significant risks to public health.These dangerous products compromise patient safety and treatment efficacy, particularly in critical areas, such as antimalarials and antibiotics. Rapid, accurate detection methods are essential to combat this growing threat and ensure medication integrity across various settings, from pharmacies to field inspections.In this webinar, Drs. Basant Giri (Kathmandu Institute of Applied Sciences) and Toni Barstis (Saint Mary’s College) will share insights about their collaboration in Nepal where there were 346 drug recalls during the period from 2010 through 2020, with approximately 75% of those being substandard or falsified. Giri and Barstis are using novel paper-based devices and a handheld Raman spectrometer for field-expedient testing and more advanced method development. They will demonstrate how these tools can work together to improve the safety and efficacy of pharmaceuticals and the safety of consumer products. Adam Hopkins, Spectroscopy Product Manager from Metrohm USA, will briefly discuss the unique features of the MIRA handheld Raman analyzer that make it ideal for this critical work<h4>Key Learning Objectives:</h4><ul><li>Insight into the sacle of the SF medicine problem: Information crucial for audience to understand the scope of the issue and its potential impact on their operations and reputation</li><li>The underlying science behind field-expedient testing methods: Knowledge is relevant for QA teams and forensic chemists who need to implement or improve field-testing protocols</li><li>Discover a practical example of how to apply Raman in a real-world setting: Benefits those involved with global supply chain management and international quality assurance efforts</li><li>Technological advancements in handheld Raman: Helps decision-makers considering investments in new quality control equipment</li></ul><h4>Who Should Attend:</h4><ul><li>VPs and Chiefs of Product Quality</li><li>Quality assurance and management team members and leads</li><li>Supply chain managers</li><li>Forensic chemists and scientists</li><li>Anyone involved in or curious about pharmacovigilance activities</li></ul><blockquote>Presenter: Dr. Basant Giri (Senior Scientist, Kathmandu Institute of Applied Sciences)Presenter:&nbsp;Dr. Toni L.O. Barstis (Professor Emeritus, Saint Mary’s College, Notre Dame, IN)Presenter:&nbsp;Dr. Adam J. Hopkins (Spectroscopy Product Manager, Metrohm USA)Presenter:&nbsp;Ann Thayer (Contributing Editor, C&amp;EN Media Group)</blockquote>

C&EN: In-field Identification of Low-Quality Medicines using Handheld Raman

In-field Identification of Low-Quality Medicines using Handheld Raman

The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines.

In-field Identification of Low-Quality Medicines

Abbemat refractometers allow fast and non-destructive refractive index and concentration measurements. All instruments of the Performance and Performance Plus lines provide full compliance with 21 CFR Part 11, including user levels, audit trail, and forgery-proof data export. The Abbemat T-Check feature precisely calibrates and adjusts the surface temperature of the measuring prism of all Anton Paar refractometers.We invite you to join us for a webinar aimed at the chemical industry as our specialist, Rene, demonstrates how the Anton Paar Abbemat can improve the quality control process.&nbsp;Objectives:<ul><li>Assure quality while reducing operating errors: enhance accuracy and reliability.</li><li>Comply with international standards: meet global standards and ensure your product meet the highest benchmarks.</li><li>Reduce waste of expensive ingredients: see first hand how precise measurements can minimize ingredient waste, optimizing your resources.</li></ul><blockquote>Presenter: René Nguyen Ph.D. (Product Specialist, Anton Paar)</blockquote>

Anton Paar: Quality Control with the Abbemat in the Chemical Industry

Quality Control with the Abbemat in the Chemical Industry

Webinar aimed at the chemical industry demonstrates how the Anton Paar Abbemat can improve the quality control process. 

During the production and packaging of lithium-ion batteries (LIB) their components are subject to mechanical and thermo-mechanical loading. The mechanical damage to the LIB cell can lead to short circuits which increase the risk of thermal runaway or decrease of the battery capacity and lifetime. Among critical properties of the LIB electrodes belong adhesion and elastic modulus.In this webinar we will present an application of the scratch test method using a wedge blade indenter for determination of adhesion of the electrode active layer.We will also show how elastic modulus, measured by nanoindentation, is related to the formulation of the active electrode layer and how mechanical properties can serve for determining more efficient electrode production process.This webinar is dedicated for all researchers in the Li-ion electrode development and mainly those concerned with mechanical characterization.Key Learning Objectives<ul><li>In this webinar we will demonstrate new methods for measurement of adhesion of functional coatings of lithium-ion battery electrodes and for characterization their mechanical properties.</li></ul>Who should attend?<ul><li>Researchers in the Li-ion electrode development in the battery industry and in academia</li></ul><blockquote>Presenter: Dr. Jiri NohavaDr. Jiri Nohava is the Head of Product Competence &amp; Lead Application Scientist at Materials Surface Characterization unit of Anton Paar. He obtained his PhD in materials science at the Czech Technical University in Prague (Czech Republic).He joined Anton Paar TriTec in 2007 and has since become a specialist in instrumented indentation, tribology and scratch testing. His main task is development of new applications with Anton Paar instruments in frame of scientific and industrial projects. He regularly publishes in peer-reviewed journals and participates at international conferences.</blockquote>

Anton Paar: Nano- and Micromechanical Characterization of Lithium-Ion Battery Electrodes: Adhesion and Hardness

Nano- and Micromechanical Characterization of Lithium-Ion Battery Electrodes: Adhesion and Hardness

Application of the scratch test method using a wedge blade indenter for determination of adhesion of the electrode active layer