Combining elemental analysis and molecular techniques to characterize Ancient Egyptian mummification balms

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, LECO and Shimadzu and technical note by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</h3>Fast, accurate AOAC compliant food analysis using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> with AVS MS and ADS 2&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf">Full PDF for download</a>&nbsp;</li></ul>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.<h4>Conclusion&nbsp;</h4>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;<ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.<h3>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf">Full PDF for download</a></li></ul>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.<h4>Instrument Model and Configuration&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883">LECO C832</a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO2.<h4>Typical Results&nbsp;</h4>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.<h3>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050">Shimadzu ICPMS-2050</a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.<h4>Conclusion</h4>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.<h3>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf">Full PDF for download</a></li></ul>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992">Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</a> (shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;<ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

Acne is one of the most common skin conditions. It affects up to 85% of people during adolescence and, for many, persists into adulthood. Beyond its physical symptoms, it can also significantly affect self-confidence. Treatment often takes time, and some commonly used products can dry out or irritate the skin. Researchers at CEITEC Brno University of Technology (BUT) have developed specially modified cellulose microfibres that effectively inhibited acne-causing bacteria in laboratory tests. The fibres can be used in face masks. These findings could pave the way for new approaches to treating&nbsp;acne-prone skin.The material consists of cellulose acetate microfibres enriched with zinc oxide and subsequently treated with oxygen plasma. The zinc oxide is then gradually released into the skin, where its antibacterial action limits the growth of bacteria associated with acne. Unlike conventional products, the active ingredient is incorporated directly into the fibres and released gradually, allowing for a longer-lasting effect.“The fibres retain high efficacy without any of the additives commonly found in commercial products. The material contains exactly what is needed to combat acne effectively, with no unnecessary ingredients. Our research showed that the fibres retain their antibacterial effect for at least a year after treatment,” says Martina Říhová of the Advanced Low-Dimensional Nanomaterials research group at CEITEC BUT, who led the research. This demonstrated long-term effect opens the door to commercial applications.In the future, the same principle could also be used to treat other skin conditions complicated by bacterial infections, such as atopic dermatitis. The fibres could be incorporated not only into face masks for acne treatment but also into patches for smaller affected areas or dressings suitable for larger areas.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová from CEITEC BUT during face skin analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg 235w," sizes="100vw" width="1600" height="1067"><h3>Fibres Made Much Like Cotton Candy</h3>The researchers produced the microscopic fibres using centrifugal spinning. The same physical principle is used to make cotton candy, but in this case, fine polymer fibres are formed instead of sugar strands.The breakthrough came from combining a method called Vapour Phase Infiltration, which enriched the fibres with zinc oxide, with subsequent oxygen plasma treatment. This treatment slightly disrupts the surface of the fibres, allowing the active substances to be released upon contact with water.“We were the first in the world to demonstrate this procedure using cellulose acetate fibres,” notes Martina, who has been researching acne and its treatment for seven years. She and her colleagues published their <a target="_blank" rel="noopener noreferrer" href="https://www.researchgate.net/publication/403127590_Cellulose_Acetate_Fibers_With_Infiltrated_ZnO_Nanocrystals_Activation_of_Antibacterial_Properties_Against_Acne_vulgaris_by_Oxygen_Plasma_Treatment">findings</a> in Small, one of the world’s leading scientific journals focusing on nanomaterials and nanotechnology.<h3>Researchers from Brno and Spain Joined Forces</h3>Several research teams from different institutions contributed to the material’s development. “Our team, led by Jan Macák, was responsible for preparing the fibres. We then took them to San Sebastián in Spain, to Mato Knez’s team at nanoGUNE, where they carried out the vapour phase infiltration. Next, Lenka Zajíčková’s team at CEITEC BUT treated the fibres with oxygen plasma. Finally, Zbyněk Heger’s team at the Department of Chemistry and Biochemistry at Mendel University conducted the antibacterial testing,” says Martina Říhová, describing the collaboration.The research took more than a year. Before the new material can enter routine use, it will need to undergo further biological testing, followed by clinical trials to verify its safety and effectiveness in treating patients.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová's microfibres developped for acne treatment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg 235w," sizes="100vw" width="1600" height="1067"><blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://onlinelibrary.wiley.com/doi/10.1002/smll.202513286">Cellulose Acetate Fibers With Infiltrated ZnO Nanocrystals: Activation of Antibacterial Properties Against Acne vulgaris by Oxygen Plasma Treatment</a></h4>Martina Rihova, Denisa Fenclova, Pavan Kumar Chennam, Aniket Mukherjee, David Pavlinak, Susan Azpeitia, Kristyna Cihalova, Miloslav Pouzar, Kaushik Baishya, Lenka Zajíčková, Zbynek Heger, Mato Knez, Jan M. MacakSmall, 2026, 22, e13286<a target="_blank" rel="noopener noreferrer" href="https://onlinelibrary.wiley.com/doi/10.1002/smll.202513286">10.1002/smll.202513286</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>In this work, we developed biodegradable cellulose acetate (CA) fibers infiltrated with ZnO nanocrystals for the Acne vulgaris (AV) treatment. The antibacterial effect (through Zn²⁺ release) was activated upon oxygen plasma treatment. CA fibers (fiber diameter ≈ 2 µm) were produced via centrifugal spinning, followed by ZnO infiltration (up to 8 wt% of Zn content) using Vapor Phase Infiltration (VPI) with varying deposition cycles. As CA fibers are naturally hydrophobic, oxygen plasma treatment was applied to turn them hydrophilic and to improve skin wetting. The combination of these steps is presented for the first time.Plasma treatment introduced oxygen‐containing functional groups on the CA surface, significantly improving wettability. Scanning electron microscopy analyses of treated fibers showed no morphological damage. Detailed characterization (using X‐ray photoelectron spectroscopy, Raman spectroscopy, energy dispersive X‐ray fluorescence, X‐ray diffraction, tranmission electron microscopy) focused on fibers with 32 and 128 VPI cycles, revealed that plasma partially oxidized and etched the surface, affecting the ZnO distribution.Plasma‐modified fibers, unlike untreated ones, exhibited antibacterial activity against AV‐causing bacteria (Cutibacterium acnes and Staphylococcus epidermidis), creating significant inhibition zones (up to 5 mm), demonstrating their potential as promising therapeutic modality. Overall, plasma treatment enabled effective surface functionalization, producing antibacterial fibers with enhanced surface properties suitable for application in AV management.

Technology Inspired by Cotton Candy Could Help Treat Acne

Article

Application

Scientific article

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Metrohm

Agilent Technologies

Technology Networks

C&EN

Shimadzu Corporation

The second edition of this online symposium will provide industry and academic scientists with the opportunity to hear from experts within the field. Focus will be given to the safety, authenticity and quality of food and beverages as well as the future of food products such as meat substitutes and alternative proteins.
<h3>This online symposium will cover:</h3>
<ul>
<li>Innovations in food and beverage analysis</li>
<li>Analytical techniques and methodologies</li>
<li>Future food</li>
<li>Contamination identification and control</li>
</ul>
<blockquote>
Presenter: Jordi Saldo Periago, PhD (Associate Professor, Universitat Autònoma de Barcelona)
</blockquote>
<blockquote>
Presenter: Manuel Castillo Zambudio, PhD (Professor, Universitat Autònoma de Barcelona)
</blockquote>
<blockquote>
Presenter: Derek Mattern, PhD (Senior Product Specialist, PerkinElmer)
</blockquote>
<blockquote>
Presenter: Nicholas Birse, PhD (Research Fellow, Queen’s University, Belfast)
</blockquote>
<blockquote>
Presenter: Lei Tian, PhD (Project Lead, McGill University)
</blockquote>
<blockquote>
Presenter: Brian Matlock (Senior Applications Specialist, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Daniel McMillan (Senior Market Development Manager, SCIEX)
</blockquote>
<blockquote>
Presenter: Sophie Letcher (PhD Candidate, Tufts University)
</blockquote>
<blockquote>
Presenter: Lovedeep Kaur, PhD (Senior Research Officer, Massey University)
</blockquote>
<blockquote>
Presenter: Trevor Morones (Founder, Co-CEO, Control Point)
</blockquote>
<blockquote>
Presenter: Noud van der Borg (Business Development Manager, Bruker)
</blockquote>

Technology Networks: Advances in Food & Beverage Analysis 2022

Advances in Food & Beverage Analysis 2022

The second edition of this online symposium will provide industry and academic scientists with the opportunity to hear from experts within the field. 

By dedicating themselves to the problem, academics and analytical chemistry experts have delivered a creative, practical and incredibly effective approach to chromium analysis that doesn’t sacrifice selectivity or sensitivity. Since chromium can exist in two forms, with one of them highly toxic, separation of the different chromium species is a critical first step in the analysis followed by use of an optimal detector.
In this webinar, we will hear from Chris LeValley, chemistry major and research contributor at the University of Wisconsin Parkside, on how he combined IC with ICP-MS to develop a robust and sensitive method for determination of chromium (VI) and chromium (III) in tap water. In addition to understanding how to run the hyphenated system, he’ll also share information regarding detection limits, spike &amp; recovery results and system stability. A basic overview of IC and ICP/MS will be given, with an emphasis on how the two techniques complement each other.
You will also hear from and get the chance to interact with a panel of additional experts who will be ready to answer your questions during the live Q&amp;A session.
<h3>Plan to attend if you:</h3>
<ul>
<li>Are interested in learning more about IC-ICP/MS and its capabilities.
</li>
<li>Are interested in learning how IC and ICP-MS instruments can work together to complement each other.
</li>
<li>Work in the environmental testing industry.
</li>
</ul>
<h3>Key learning points:</h3>
<ul>
<li>Develop an understanding of how IC and ICP-MS can complement each other to provide enhanced selectivity and sensitivity.
</li>
<li>Learn how IC-ICP/MS is an optimal technique for speciating low levels of chromium(VI) and chromium (III) in drinking water.
</li>
</ul>
<blockquote>
Presenter: Christopher LeValley (Student and Researcher, University of Wisconsin-Parkside)
</blockquote>
<blockquote>
Christopher LeValley is a senior at the University of Wisconsin-Parkside where he&#39;s involved in the finishing touches on the data for tap water analysis, as well as the bulk of data of several bottled waters, apple juice and orange juice. Chris is seeking an undergraduate bachelor’s degree in Professional Chemistry and Criminal Justice, with a certificate in green chemistry and is currently an intern at PPG. His experience involves sample preparation and operating for IC-ICPMS, focusing on the analysis of trivalent and hexavalent chromium in different beverages.
</blockquote>
<blockquote>
Presenter: Yan Cheung (ICP-MS Application Scientist, Agilent)
</blockquote>
<blockquote>
Yan Cheung is a ICP-MS Application Scientist at Agilent Technologies who received a Ph.D. in Analytical Chemistry from Indiana University Bloomington. She brings over 15 years of experiment experience in both ICPMS and ICPOES techniques. She has worked at Chevron where she used ICPMS and ICPOES and also did work at Phillips 66 as the ICPMS and ICPOES Subject Matter Expert before joining Agilent.
</blockquote>
<blockquote>
Presenter: Dr. Jay Gandhi (Sr. Market Development Scientist, Metrohm USA)
</blockquote>
<blockquote>
Dr. Jay Gandhi is the Vertical Markets Manager at Metrohm USA. He brings over 30 years of experience in analytical instrumentation and techniques in medical research and in various fields including environmental, petrochemical and pharmaceutical. He has held positions at Varian and NASA and has shepherd several ASTM and USEPA methods. Dr. Gandhi is a non-paid adjunct faculty member at the University of Houston-Clearlake where he enjoys guiding graduate and post graduate students in their independent study program.m
</blockquote>

Metrohm: IC-ICP/MS Analysis of Trace Chromate

IC-ICP/MS Analysis of Trace Chromate

We will learn how he combined IC with ICP-MS to develop a robust and sensitive method for determination of chromium (VI) and chromium (III) in tap water.

Consumer products are complex mixtures that rely on careful formulations and precision chemistry to deliver the desired properties. These properties can be chemical, such as the peroxide content of an oxidizer, physical, such as polymer viscosity or fungible, such as the reserve acidity of a mixture. Measuring these and other types of properties typically requires a fleet of instrumentation and is often limited to raw material input and final product testing. These testing throughput limits place a high burden on the analytical lab, making product improvement difficult. Near-infrared spectroscopy (NIR) is a laboratory tool that can relieve the throughput limitation and be deployed to multiple products and problems at the same time.
Register for this webinar to hear Alex Mattingly, Product Specialist at Chemlink Laboratories, explain how he uses NIR to address manufacturing challenges and increase production efficiency. He will show how he implemented NIR and developed the analytical methods to replace complex wet-chemical assays. Elena Hagemann, Metrohm USA Spectroscopy Applications Scientist, will give an overview of NIR spectroscopy and explain how the fundamentals of this technique make it well-suited for formulated products.
Join these experts after the presentation and get your specific questions answered during the live Q&amp;A.
<h5>Key Learning Objectives:</h5>
<ul>
<li>Discover how NIR gives quicker results and better response time than other analytical technologies </li>
<li>Gain understanding on how NIR can analyze pH and acidity of buffer systems </li>
<li>Understand how viscosity and molecular weight of PEGs can easily be determined using NIR</li>
<li>Learn how NIR method development is as simple as linking spectral information of representative samples</li>
</ul>
<h5>Who Should Attend:</h5>
<ul>
<li>Those in the consumer products industry, both specialty chemical and final product manufacturers looking to increase production quality and efficiency </li>
<li>Production and QA managers of all industries seeking solutions to get actionable data fasters </li>
<li>Product development chemists seeking to design products for quality and manufacturability</li>
</ul>
<blockquote>
Presenter: Alex Mattingly (Product Specialist, Chemlink)
</blockquote>
<blockquote>
Presenter: Elena Hagemann (Applications Specialist, Metrohm USA)
</blockquote>
<blockquote>
Presenter: Melissa O&#39;Meara (Forensic Science Consultant, C&amp;EN Media Group)
</blockquote>

C&EN: Slashing Inefficiencies in Consumer Product Manufacturing with NIR Spectroscopy

Slashing Inefficiencies in Consumer Product Manufacturing with NIR Spectroscopy

Alex Mattingly from Chemlink Laboratories will show how he implemented NIR and developed the analytical methods to replace complex wet-chemical assays.

Consumer Product Manufacturing with NIR Spectroscopy

A calibration curve or regression is always plotted with the instrument responses on the dependent vertical (y -) axis and the standard concentrations on the horizontal (x -) axis. As a linearity of calibration regression minimizes random errors of the instrument, we aim to find the best straight line to pass through these calibration points.
<ul>
<li>What are the estimated errors and confidence limits we can estimate for the slope (or gradient) and the y-intercept of the line?
</li>
<li>What is the uncertainty of the analyte concentration found on the calibration curve?
</li>
<li>What are the least concentration of the measurand can be detected with, say 95% confidence?
</li>
<li>In other words, what is the limit of detection (LOD) of this method?
</li>
</ul>
This one-day training program is designed to answer all the above questions and others related to the subjects of linear regression of instrument calibration and detection limits including IDL, MDL and LOQ.
<h3>Training Program (8:00 - 10:30 CEST)</h3>
<ul>
<li>Introduction</li>
<li>Different meanings for correlation and regression</li>
<li>Assumptions of linear regression and correlation</li>
<li>Residual analysis – what and how</li>
<li>Uncertainty estimation of linear calibration regression</li>
<li>Must your linear regression always pass through its origin (0,0)?</li>
<li>The most controversial subject in analytical chemistry – Limit of Detection LOD</li>
<li>Different definitions for LOD and its basic concepts</li>
<li>Differences between IDL, MDL, LOQ</li>
<li>Determining LOD by linear calibration model</li>
</ul>
<h5>Who should attend:</h5>
This course is designed for those who want to know more about the sampling procedures and how it affects the validity of their test results, including:
<ul>
<li>Laboratory analysts</li>
<li>Laboratory QA/QC personnel</li>
<li>Lab directors / managers</li>
<li>Personnel who carry out tasks such as method validation and uncertainty estimation</li>
</ul>
<h5>Pre-requisites</h5>
The participants are assumed to have had some basic statistical knowledge such as the calculation of mean, standard deviation, coefficient of variation, relative standard deviation, etc.
Participants are to have a laptop with Microsoft Excel installed and have some very basic knowledge of how to use the program.
<blockquote>
Presenter: Yeoh Guan Huah
</blockquote>
<blockquote>
Mr Yeoh Guan Huah has B.Sc. (Hons) and M.Sc. degrees in Chemistry and was former Managing Director of ALS Technichem Singapore (1978-2006), former East Asia Regional Manager of ALS Group of Laboratories in Hong Kong and China (2006-2016). He is now the senior partner of GLP Consulting, Singapore.
</blockquote>
<blockquote>
Currently Mr Yeoh is an appointed External Lead Assessor and Technical Assessor of SAC-SINGLAS till 31 March 2025 and had represented DSM/SIRIM Malaysia as a active member of ISO Technical Committee TC 69 (Application of Statistical Methods) and Convenor of AHG1 from 2005-2016.
</blockquote>

Agilent Technologies: Uncertainty of Linear Calibration Curve & Detection Limit

Uncertainty of Linear Calibration Curve & Detection Limit (Part 1)

We will answer all questions related to the subjects of linear regression of instrument calibration and detection limits including IDL, MDL and LOQ.

Uncertainty of Linear Calibration Curve & Detection Limit

A UV-VIS spectrometer is a powerful and versatile tool for material analysis. It is capable of providing very quick information of sample composition and concentration for quality control in addition to indicating how samples change versus time or temperature.
In this webinar, we will go over what is happening when we take a UV-VIS measurement, discuss how measurement parameters can improve our data collection, and look at applications like concentration and kinetics.
<blockquote>
Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
</blockquote>

Agilent Technologies: Understanding Your UV-Vis Measurements

Understanding Your UV-Vis Measurements

What is happening when we take a UV-VIS measurement, how measurement parameters can improve our data collection, and look at applications.

21 CFR Part 11 regulations and requirements for UV-VIS spectrometers can seem intimidating. Agilent&#39;s Cary 60 and Cary 3500 UV-VIS spectrometers are capable of meeting these requirements and are here to help.
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Presenter: Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)
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Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.
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Agilent Technologies: Meeting 21 CFR Part 11 Compliance With UV-Vis Spectrometers

Meeting 21 CFR Part 11 Compliance With UV-Vis Spectrometers

Agilent's Cary 60 and Cary 3500 UV-VIS spectrometers are capable of meeting 21 CFR Part 11 regulations and requirements  and are here to help.

Single cell analysis is made possible with quadrupole ICPMS thanks to advanced developments. Now with sample introduction automation, researches and discoveries are greatly improved with efficiency and accuracy.
Join us in this webinar to learn about how this single cell analysis application can benefit your lab and your research. 
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Presenter: Yan Cheung (Applications Chemist, Agilent Technologies, Inc.)
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Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.
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Agilent Technologies: Single cell Analysis with Agilent ICP-MS and ESI MicroFAST

Single cell Analysis with Agilent ICP-MS and ESI MicroFAST

 Join us in this webinar to learn about how this single cell analysis application can benefit your lab and your research. 

This is a dive into using Intelliquant and streamlining your analysis with sublist for specific needs of your customers.
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Presenter: L. Craig Jones (ICP-MS Application Scientist, Agilent Technologies, Inc.)
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Craig has been with Agilent for over 15 years as an ICP-MS applications scientist. He has been involved with multiple type of applications for ICP-MS, including environmental, pharmaceutical, nutraceutical, semiconductor, geologic, and clinical analyses, to name a few. Previous to Agilent he worked in an environmental lab performing analysis and supervising both the inorganic and organic sections of the laboratory. In his spare time, Craig enjoys volunteering at the local marine science center, mountain biking, hiking and relaxing at the beach. Craig obtained a bachelor of science degree in chemistry from Fort Lewis College in Durango, CO.
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Agilent Technologies: Diagnosing your analysis using Intelliquant and the benefits of using sublist

Diagnosing your analysis using Intelliquant and the benefits of using sublist

This is a dive into using Intelliquant and streamlining your analysis with sublist for specific needs of your customers.

Diagnosing your analysis using Intelliquant

There are massive amounts of plastic waste released into ecosystems, generating huge amounts of microplastics (MPs) and nanoplastics (NPs) during the environmental aging process. Particle size and number dynamics along the aging process have not been quantitatively assessed, which can greatly influence their fate and environmental risk assessment.
Dr. Huang and his group have applied single particle inductively coupled plasma mass spectroscopy (spICP-MS) to quantitatively analyze the polystyrene (PS) MPs aging process with a wide particle size range (800 nm−5 μm) as well as particle number concentration at an environmentally relevant value (down to 7.1 × 106 particles/L).
This webinar will uncovered and quantified MPs particle size and concentration during the aging process, which is essential to assessing ecotoxicological risks of MPs/NPs.
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Presenter: Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)
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Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Chemist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at University of California, Davis since 2013. Jenny has been very active with AOAC and ASTM over the past 8 years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry.
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Jenny has extensive experience in operating and method development for Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) and Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Jenny has broad knowledge and experience in different speciation analysis for many sample matrices using GC-ICPMS, LC-ICPMS. As well as vast experience with sp-ICP-MS, for many applications.
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Agilent Technologies: Quantifying the Dynamics of Polystyrene Microplastics UV-Aging Process

Quantifying the Dynamics of Polystyrene Microplastics UV-Aging Process

Uncover and quantify MPs particle size and concentration during the aging process, which is essential to assessing ecotoxicological risks of MPs/NPs.

Dynamics of Polystyrene Microplastics UV-Aging Process

This webinar discusses about total solution approach for USP Chapters &lt;232&gt;/ &lt;233&gt; and ICHQ3D.
We will clarify regulatory requirements and recommended analytical methods for elemental impurities analysis in Pharmaceuticals.
Join us to learn about total workflow of microwave digestion for sample preparation and instrumental analysis using ICPMS following total regulatory compliance for data management. Also learn about how to overcome the challenges posed by ICHQ3D guideline, by removing metals from APIs or intermediates using metal scavengers.
<h5>Learning Objectives:</h5>
<ul>
<li>Elemental Impurities Regulations: USP Chapters &lt;232&gt;/ &lt;233&gt;, ICH Q3D
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<li>Elemental Analysis Workflow using ICPMS in compliance with USP &lt;232&gt; and &lt;233&gt;
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<li>Implementing Microwave Digestion technology for Sample preparation 
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<li>Mitigating the common Metal Impurities in Pharmaceutical Products using Metal Scavengers
</li>
</ul>
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Presenter: Dr. Pravin Konde (Product Specialist (Atomic Spectroscopy), Shimadzu Asia Pacific)
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Dr. Pravin is a Product Specialist (Atomic Spectroscopy) at Shimadzu Asia Pacific and has been based at Singapore. He has more than 12 years of industry experience of which about 10 years in analytical instruments with expertise in trace element analysis applications using AAS, ICP-OES &amp; ICP-MS. He is engaged primarily in technical support to regional sales teams and customers. Prior to joining industry, he has done his PhD in Chemistry from Institute of Chemical Technology (formerly UDCT), Mumbai, India.
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Presenter: Yogesh Baldua (Dy. General Manager (Elemental &amp; Spectroscopy), Toshvin Analytical Pvt. Ltd.)
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Yogesh is Deputy General Manager at Toshvin Analytical, India. He has overall 20 years of working experience in analytical instruments industry and has worked with many leading Multinational and Indian organizations. In his current role at Toshvin, he provides product and technical support to the sales team on Shimadzu elemental analysis products like AAS, ICPE, ICPMS and PreeKem Scientific for wide range of microwave digestion systems.
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Presenter: Sunil Rana (Global Business Manager for Biotage Scale-Up business, Biotage AB, Sweden)
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Dr. Sunil gained his BSc. Double Honours degrees in Chemistry and Biochemistry from the University of Southampton, UK in 1997 and completed an organic polymer/peptide chemistry PhD. with Professor Mark Bradley. During an Industrial post-doc at Argonaut Technologies, USA, he developed novel supported reagents/scavengers, then headed the analytical and chemical production groups. In 2008, he moved from Senior Scientist/Project Manager to Global product management. Sunil has an MBA from the Open University (UK), is a member of the ACS (21+yrs) and been involved in numerous publications and patent applications. He is Global Business Manager for Biotage Scale-Up business.
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Shimadzu: USP <232>/ <233> and ICH Q3D | Prepare Your Lab to Measure and Mitigate Elemental Impurities in Drug Products