<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO </strong>and <strong>Shimadzu</strong> and technical note by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</strong></h3><p><strong>Fast, accurate AOAC compliant food analysis using the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ</strong></a><strong> with AVS MS and ADS 2&nbsp;</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.</p><p>To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 Triple Quadrupole ICP-MS</strong></a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;</p><p>In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;</p><p>Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;</p><p>Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;</p><ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul><p>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.</p><h3><strong>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883"><strong>LECO C832</strong></a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO<sub>2</sub>.</p><h4><strong>Typical Results&nbsp;</strong></h4><p>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.</p><h3><strong>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul><p>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050"><strong>Shimadzu ICPMS-2050</strong></a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;</p><p>While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.</p><h4><strong>Conclusion</strong></h4><p>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;</p><p>The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;</p><p>LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.</p><h3><strong>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</strong></a><strong> </strong>(shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.</p><p>User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;</p><ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

<p><strong>Acne is one of the most common skin conditions. It affects up to 85% of people during adolescence and, for many, persists into adulthood. Beyond its physical symptoms, it can also significantly affect self-confidence. Treatment often takes time, and some commonly used products can dry out or irritate the skin. Researchers at CEITEC Brno University of Technology (BUT) have developed specially modified cellulose microfibres that effectively inhibited acne-causing bacteria in laboratory tests. The fibres can be used in face masks. These findings could pave the way for new approaches to treating&nbsp;acne-prone skin.</strong></p><p>The material consists of <strong>cellulose acetate microfibres enriched with zinc oxide and subsequently treated with oxygen plasma</strong>. The zinc oxide is then gradually released into the skin, where its <strong>antibacterial action limits the growth of bacteria associated with acne</strong>. Unlike conventional products, the active ingredient is incorporated directly into the fibres and released gradually, allowing for a <strong>longer-lasting effect</strong>.</p><p><i>“The fibres retain high efficacy without any of the additives commonly found in commercial products. The material contains exactly what is needed to combat acne effectively, with no unnecessary ingredients. Our research showed that the fibres retain their antibacterial effect for at least a year after treatment,”</i> says <strong>Martina Říhová of the </strong><i><strong>Advanced Low-Dimensional Nanomaterials</strong></i><strong> research group at CEITEC BUT</strong>, who led the research. This demonstrated long-term effect opens the door to commercial applications.</p><p>In the future, the same principle could also be used to treat other skin conditions complicated by bacterial infections, such as <strong>atopic dermatitis</strong>. The fibres could be incorporated not only into face masks for acne treatment but also into patches for smaller affected areas or dressings suitable for larger areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová from CEITEC BUT during face skin analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg 235w," sizes="100vw" width="1600" height="1067"></p><h3><strong>Fibres Made Much Like Cotton Candy</strong></h3><p>The researchers produced the microscopic fibres using <strong>centrifugal spinning</strong>. The same physical principle is used to make cotton candy, but in this case, fine polymer fibres are formed instead of sugar strands.</p><p>The breakthrough came from combining a method called <strong>Vapour Phase Infiltration</strong>, which enriched the fibres with zinc oxide, with subsequent oxygen plasma treatment. This treatment slightly disrupts the surface of the fibres, allowing the active substances to be released upon contact with water.</p><p><i>“We were<strong> </strong>the <strong>first in the world</strong> to demonstrate this procedure using cellulose acetate fibres,”</i> notes Martina, who has been researching acne and its treatment for seven years. She and her colleagues published their <a target="_blank" rel="noopener noreferrer" href="https://www.researchgate.net/publication/403127590_Cellulose_Acetate_Fibers_With_Infiltrated_ZnO_Nanocrystals_Activation_of_Antibacterial_Properties_Against_Acne_vulgaris_by_Oxygen_Plasma_Treatment"><strong>findings</strong></a><strong> in </strong><i><strong>Small</strong></i>, one of the world’s leading scientific journals focusing on nanomaterials and nanotechnology.</p><h3><strong>Researchers from Brno and Spain Joined Forces</strong></h3><p>Several research teams from different institutions contributed to the material’s development. <i>“Our team, led by <strong>Jan Macák</strong>, was responsible for preparing the fibres. We then took them to San Sebastián in Spain, to <strong>Mato Knez’s team</strong> at <strong>nanoGUNE</strong>, where they carried out the vapour phase infiltration. Next, <strong>Lenka Zajíčková’s team at CEITEC BUT</strong> treated the fibres with oxygen plasma. Finally,<strong> Zbyněk Heger’s team at the Department of Chemistry and Biochemistry at Mendel University</strong> conducted the antibacterial testing,”</i> says Martina Říhová, describing the collaboration.</p><p>The research took more than a year. Before the new material can enter routine use, it will need to undergo further biological testing, followed by clinical trials to verify its safety and effectiveness in treating patients.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová's microfibres developped for acne treatment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg 235w," sizes="100vw" width="1600" height="1067"></p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.researchgate.net/publication/403127590_Cellulose_Acetate_Fibers_With_Infiltrated_ZnO_Nanocrystals_Activation_of_Antibacterial_Properties_Against_Acne_vulgaris_by_Oxygen_Plasma_Treatment"><strong>Cellulose Acetate Fibers With Infiltrated ZnO Nanocrystals: Activation of Antibacterial Properties Against Acne vulgaris by Oxygen Plasma Treatment</strong></a></h4><p>Martina Rihova, Denisa Fenclova, Pavan Kumar Chennam, Aniket Mukherjee, David Pavlinak, Susan Azpeitia, Kristyna Cihalova, Miloslav Pouzar, Kaushik Baishya, Lenka Zajíčková, Zbynek Heger, Mato Knez, Jan M. Macak</p><p><i><strong>Small</strong></i>, 2026, <strong>22</strong>, e13286</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/smll.202513286?urlappend=%3Futm_source%3Dresearchgate.net%26utm_medium%3Darticle">10.1002/smll.202513286</a></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>In this work, we developed <strong>biodegradable cellulose acetate (CA) fibers infiltrated with ZnO nanocrystals</strong> for the <strong>Acne vulgaris (AV) treatment</strong>. The antibacterial effect (through <strong>Zn²⁺ release</strong>) was activated upon oxygen plasma treatment. CA fibers (<strong>fiber diameter ≈ 2 µm</strong>) were produced via <strong>centrifugal spinning</strong>, followed by ZnO infiltration (<strong>up to 8 wt% of Zn content</strong>) using <strong>Vapor Phase Infiltration (VPI)</strong> with varying deposition cycles. As CA fibers are naturally hydrophobic, oxygen plasma treatment was applied to turn them hydrophilic and to improve skin wetting. <strong>The combination of these steps is presented for the first time.</strong></p><p>Plasma treatment introduced <strong>oxygen‐containing functional groups</strong> on the CA surface, significantly improving wettability. <strong>Scanning electron microscopy</strong> analyses of treated fibers showed no morphological damage. Detailed characterization (<strong>using X‐ray photoelectron spectroscopy, Raman spectroscopy, energy dispersive X‐ray fluorescence, X‐ray diffraction, tranmission electron microscopy</strong>) focused on fibers with <strong>32 and 128 VPI cycles</strong>, revealed that plasma partially oxidized and etched the surface, affecting the ZnO distribution.</p><p><strong>Plasma‐modified fibers</strong>, unlike untreated ones, exhibited antibacterial activity against AV‐causing bacteria (Cutibacterium acnes and Staphylococcus epidermidis), creating significant <strong>inhibition zones (up to 5 mm)</strong>, demonstrating their potential as promising therapeutic modality. Overall, plasma treatment enabled effective <strong>surface functionalization</strong>, producing antibacterial fibers with enhanced surface properties suitable for application in <strong>AV management</strong>.</p>

Technology Inspired by Cotton Candy Could Help Treat Acne

<p><strong>Proper care and maintenance of HPLC columns are essential for getting accurate results and saving on replacement costs. Extending the HPLC column life not only ensures consistent performance but also reduces downtime and the need for frequent replacements.</strong></p><p>Routine maintenance is equally essential for sustaining column functionality. Correct handling of the column is paramount, ensuring strict compliance with the manufacturer’s specifications regarding pressure, pH, flow rate, and temperature.</p><p>In the next section, we will explore these best practices in greater detail, offering further guidance on essential HPLC column maintenance strategies. Whether you’re working in a high-throughput lab, or conducting occasional analyses, these strategies will help you get the most out of your<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=48&amp;manufacturerItems=50"><strong>HPLC columns</strong></a>.</p><h3><strong>Essential Guidelines for Extending HPLC Column Life</strong></h3><p>By adopting these simple yet effective practices, you can greatly extend the HPLC column life while ensuring reliable, high-quality results in your analyses.</p><h4><strong>Proper Column Handling</strong></h4><p>HPLC columns should be handled with care to prevent physical damage or shock. The pump should not be started at high flow rates; instead, the flow rate should be gradually increased over several minutes. A pump pressure limit should be set to protect the column from over pressuring, as sudden pressure changes can lead to voids, negatively affecting the column’s performance.</p><h4><strong>HPLC Column Conditioning and Equilibration</strong></h4><p>Conditioning is a critical step for preparing a new or stored HPLC column by replacing the storage solvent with the desired mobile phase. Care must be taken to avoid introducing immiscible solvent mixtures into the column. Universally miscible solvents such as <strong>THF (tetrahydrofuran) </strong>or <strong>IPA (isopropyl alcohol) </strong>can be useful for this process when moving from normal phase to reversed phase solvent systems. Care must also be taken to ensure that solvents that may be damaging to a specific stationary phase are avoided.</p><p>For example, if a reversed-phase column experiences <strong>phase collapse </strong>due to 100% aqueous mobile phases, it should be reactivated. This process involves running 100% acetonitrile at a high flow rate and a temperature as high as 60°C. It is essential to ensure no solid buffers precipitate from residual solvents. Depending on the column condition, between <strong>50 and 100 column volumes </strong>are needed for complete reactivation and equilibration, restoring the column’s efficiency for future use.</p><h4><strong>Optimizing Operating Conditions</strong></h4><p>Optimizing operating conditions is paramount to enhancing HPLC column efficiency and prolonging their operational lifespan. A fundamental aspect of this is strict adherence to the manufacturer’s recommended <strong>temperature, pH and pressure parameters</strong>.</p><p>Deviating from these limits, particularly by operating at<strong> elevated temperatures</strong>, can significantly hasten the degradation of the stationary phase and hardware, thereby compromising overall performance. Elevated temperatures can also narrow the pH operating range, exacerbating the risk of column degradation through phenomena such as peak broadening or diminished efficiency.</p><p>Effective <strong>pressure management</strong> is equally crucial. Sudden pressure surges or mechanical shocks can result in bed voiding, leading to poor chromatographic performance, such as split peaks and reduced separation efficiency. Gradual ramping of flow and pressure, implemented each time the column is initiated, mitigates these risks. Many modern HPLC systems are equipped with automated flow-pressure ramping capabilities, ensuring smoother transitions and reducing the potential for column damage.</p><p>In addition, vigilant monitoring of the<strong> mobile phase's pH </strong>is vital to the maintenance of HPLC column integrity. Deviations from the optimal pH range can cause significant harm to the stationary phase. For instance, leads to ligand hydrolysis which leads to a loss of stationary phase functionality and diminished column performance over time. High pH can lead to silica degradation. This weakens the silica structure, causing particle dissolution, void formation, and loss of column efficiency. Maintaining the pH within optimal boundaries is essential for preserving the column’s structural integrity and ensuring consistent chromatographic performance.</p><p>Furthermore, incorporating <strong>inline filters and guard columns</strong> into the system serves as a proactive measure to prevent particulates and harsh sample matrices from damaging the analytical column. These preventive tools significantly enhance operational conditions and safeguard the column from contamination, ultimately contributing to extended HPLC column lifetime and reliable performance.</p><h4><strong>Regular Column Maintenance</strong></h4><p>Effective routine maintenance is paramount to extending the HPLC column lifetime and ensuring the consistent performance of HPLC columns. A critical aspect of this maintenance is the thorough washing of the column after each use to eliminate residual sample components and mobile phase contaminants.</p><p>The cleaning process generally involves performing an isocratic or gradient wash using a solvent system similar to the one previously used on the column but substituting the buffer with HPLC-grade water. This helps effectively remove any residual buffer components from the column. This meticulous cleaning process is vital to preventing the accumulation of impurities that could compromise the stationary phase and lead to decreased efficiency over time.</p><p>Post-cleaning, it is imperative to <strong>end-cap the column</strong> before storage to prevent the stationary phase from drying out, a condition that can negatively impact the column’s future performance. Proper capping or sealing ensures that the column remains in optimal condition, safeguarding its structural integrity and readiness for subsequent analyses.</p><p>Additionally, utilizing an older HPLC system as a dedicated wash station can further streamline maintenance practices, freeing up live systems for active use. Consistently adhering to a rigorous cleaning and storage regimen not only enhances the longevity of HPLC columns but also guarantees the delivery of precise and reliable analytical results.</p><p>For severe contamination or pressure buildup, <strong>backflushing </strong>may be necessary to dislodge tightly bound contaminants. However, backflushing should only be performed when absolutely necessary, as it can stress the column packing material. It is essential to consult the manufacturer’s instructions before attempting this method.</p>

How to Extend the Lifetime of HPLC Columns?

Article

Application

Academy

Science and research

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

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LabRulez

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Bruker

<p><strong>LUMOS II ushers in a new era in FT-IR Microscopy.</strong></p><blockquote><p><strong>Presenter: &nbsp;</strong>Dr. Tom Tague (Applications Manager and Chair of the Safety Committee Bruker Corporation)</p><div><p>Dr. Tom Tague is the Applications Manager (FTIR and Raman products) and Chair of the Safety Committee for Bruker Corporation. He is also a member of the Visiting Advisory Committee of the Metropolitan Museum of Art in New York and the Advisory Board of Amplified Sciences. Dr. Tague received his Ph.D. from the University of Utah in Physical Chemistry and his B.S. in Chemistry, from the University of Texas at San Antonio. He conducted his postdoctoral research at the University of Virginia working with professor Lester Andrews. He is a member of the American Chemical Society, the Society for Applied Spectroscopy, the American Physical Society, and the Optical Society of America. Dr. Tague is active in developing new methods and instrumentation with the goal of improving the sensitivity and detection limits of spectroscopy related applications. Dr. Tague has more than 80 publications and 5 patents.</p></div></blockquote>

Bruker: The State-of-the-Art in Infrared Microscopy

The State-of-the-Art in Infrared Microscopy

LUMOS II ushers in a new era in FT-IR Microscopy.

<p><strong>In an emission experimental setup, the sample itself acts as light source of the spectrometer and may emit light in various scenarios, e.g.: thermal emission, photoluminescence or the characterization of self-made lasers and other emission devices. Therefore, emission spectroscopy is established in versatile application fields in academia as well as in industrial applied research &amp; development or failure analysis.</strong></p><p>Bruker provides innovative instrumental solutions for emission spectroscopy with a broad palette of research spectrometers, dedicated measurement modules and accessories. In a series of customer webinars, we will explain the basic principles and give application examples as well as practical handling hints for emission spectroscopy.</p><div><div><div><div><blockquote><h5><strong>Part 1: General Setup of Emission Experiments and Determination of Emissivity.</strong></h5><p><a data-g-name="CallToAction" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1595203200000,&quot;onWebinar&quot;:true,&quot;external&quot;:true}" data-protectable="" rel="noopener" target="_blank"><a target="_blank" rel="noopener noreferrer" href="https://register.gotowebinar.com/recording/6908255056900555277"><strong>Watch Recording of Part 1&nbsp;</strong></a></a></p></blockquote><div><blockquote><h5><strong>Part 2: Photoluminescence (PL) Experiments: Challenges and the Suitable Instrumental Solutions.</strong></h5><p><a data-g-name="CallToAction" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1595203200000,&quot;onWebinar&quot;:true,&quot;external&quot;:true}" data-protectable="" rel="noopener" target="_blank"><a target="_blank" rel="noopener noreferrer" href="https://register.gotowebinar.com/recording/216857088501568015"><strong>Watch Recording of Part 2&nbsp;</strong></a></a></p></blockquote><div><blockquote><h5><strong>Part 3: Step Scan as a Powerful Tool for Emission Experiments and Source Characterization.</strong></h5><p><a data-g-name="CallToAction" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1595203200000,&quot;onWebinar&quot;:true,&quot;external&quot;:true}" data-protectable="" rel="noopener" target="_blank"><a target="_blank" rel="noopener noreferrer" href="https://register.gotowebinar.com/recording/6306834291730245889">W<strong>atch Recording of Part 3&nbsp;</strong></a></a></p></blockquote></div></div></div></div></div></div>

FTIR Emission Spectroscopy

We will explain the basic principles and give application examples as well as practical handling hints for emission spectroscopy.

<div><p><strong>This webinar introduces scattering scanning nearfield optical microscopy (s-SNOM), which provides&nbsp;information about the complex optical properties of the nanoscale region of a sample under a metallized tip that nanofocuses optical radiation. Recent developments in novel methods, advanced light sources, and refined instrumentation have made s-SNOM more valuable and accessible.</strong></p><p>Capabilities for s-SNOM are available on Bruker’s <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s.html">nanoIR3-s</a> and <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s-broadband.html">nanoIR3-s Broadband</a> platforms, and the technique itself was developed in collaboration with the webinar’s guest speaker, Professor Markus Raschke, Dept. of Physics/JILA, University of Colorado.</p><p>After a thorough and illustrative introduction to the method, Prof. Raschke presents his research efforts towards using s-SNOM, this new dimension in optical nanoprobe imaging, to access the functional properties of materials and systems including electronic materials, energy materials, nano-biomaterials, quantum systems, and more.</p><p>Following Prof. Raschke’s comprehensive presentation, he answers questions from the audience covering topics from the maximum sensitivity level of s-SNOM to the use of complementary AFM techniques with s-SNOM.&nbsp;</p></div>

Bruker: Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Recent Advancements in Infrared Nano-imaging with Nano-FTIR Spectroscopy

Learn how s-SNOM advances understanding of the functional properties of materials

Advances in Infrared Nano-imaging with Nano-FTIR

<div><div><div><p><strong>Due to the systematic shrinking of the size of devices in the semiconductor industry, characterizing nanoscale surface contaminations in interconnects and circuitries has become a pivotal issue in test and failure analysis. Continuous development in process technology/engineering has led to the fabrication of semiconductor devices with sub-µm feature resolution, which in turn demands high-resolution analytical tools for proper characterization.&nbsp;</strong></p><p>Nanoscale AFM-IR spectroscopy is a non-destructive chemical analysis method that takes advantage of the nanoscale capabilities of AFM and outputs easy-to-understand, FTIR-like spectra. As described by the presenters, the advantages of nanoscale AFM-IR can be leveraged in the semiconductor industry in many ways, like for chemical characterization of organic contaminants, nano-patterned metal/low-k dielectrics, and directed self-assembly of block copolymers.</p></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/two-complementary-nanoscale-ir-techniques-photothermal-afm-ir-and-s-snom.html"><strong>watch part 1: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/chemical-characterization-of-heterogenous-polymeric-materials-on-the-nanoscale-using-photothermal-afm-ir.html"><strong>watch part 3: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1587340800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote></div></div>

Bruker: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices

Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices

Characterizing nanometer-scale features in semiconductor devices using nanoIR spectroscopy

Nanoscale AFM-IR for Failure Analysis of Electronics

<div><p><span style="letter-spacing:0.0px;"><strong>This webinar will show you the analysis of two standard samples in failure analysis and troubleshooting with the LUMOS II.&nbsp;</strong></span></p><p>Our application specialist Eric Klein skips lengthy PowerPoint presentations and welcomes you directly to our demo lab for a hands-on instrument session. After 20 minutes of analyzing typical samples, Eric will answer your questions about using µ-FT-IR in your daily QC and failure analysis for at least 30 minutes.</p><p><strong>About the samples:</strong></p><ul><li>The first sample is a typical customer complaint which was returned due to an unknown contaminant on the products surface.</li><li>The second sample is is a product contamination found during quality control. It is analyzed to understand the contamination route and prevent recurrence.</li></ul><p><strong>Content of webinar:</strong></p><ul><li>Measurement two typical µ-FT-IR samples</li><li>Detection and identification of unknown contaminants</li><li>Q&amp;A session on failure analysis by FT-IR</li></ul><p><strong>What you'll learn:</strong></p><ul><li>How to FT-IR microscopy is used to analyze contaminations.</li><li>How to apply the LUMOS II FT-IR microscope</li><li>How to evaluate using OPUS software</li></ul><blockquote><p><strong>Presenter: </strong>Eric Klein&nbsp;</p><p>Eric Klein has been with Bruker for 10 years and started out as an application scientist. During this time, he has acquired a great deal of expertise in infrared microscopy and, as a product manager, played a leading role in the development of LUMOS II. The session will be moderated.</p></blockquote></div>

Bruker: About Failure Analysis, Customer Complaints and Troubleshooting

About Failure Analysis, Customer Complaints and Troubleshooting

This webinar will show you the analysis of two standard samples in failure analysis and troubleshooting with the LUMOS II. 

Failure Analysis, Complaints & Troubleshooting Insights

<div><p><strong>Photothermal AFM-IR can provide nanoscale chemical information with highly resolved IR spectra, that directly correlate to FTIR transmission spectroscopy. This webinar covers numerous AFM-IR applications in the field of life sciences, illustrating broad applicability for samples from tissue to single protein fibrils. The speaker also discusses issues, challenges, and potentials of correlative measurements.</strong></p><p><strong>Some of the samples and applications presented include:</strong></p><ul><li>Lipids bodies stored in microorganisms</li><li>Abnormal accumulations in kidney biopsy</li><li>Penetration of nanocarriers in tissue or model cell lines</li><li>Protein nano-assemblies structures</li></ul><p><strong>The speaker discusses the new experimental approaches developed to solve problems encountered during these studies, and the efforts to overcome technical constraints imposed by the system itself, such as:</strong></p><ul><li>Configuration of illumination</li><li>Sensitivity</li><li>Soft-sample damage</li></ul></div>

Bruker: Photothermal AFM-IR Spectroscopy and Imaging for Life Science

Photothermal AFM-IR Spectroscopy and Imaging for Life Science

This webinar explores AFM-IR applications in life sciences, showing its wide use from tissue samples to single protein fibrils.

Photothermal AFM-IR for Life Science Spectroscopy & Imaging

<div><p><strong>During this webinar, the speaker considers how photothermal AFM-IR can benefit the polymer characterization applications of:</strong></p><ul><li>Multilayer films</li><li>Polymer blends/block copolymers</li><li>Organic photovoltaics</li></ul><div><div><div><p>This webinar covers numerous academia and industry applications in the field of polymer characterization. To illustrate the broad applicability, select examples are discussed in detail, ranging from phase separation in polymer blends/block copolymers and reverse engineering in multilayer films to fibers and thin film characterization. This webinar shows how photothermal AFM-IR provides nanoscale chemical information with highly resolved IR spectra that directly correlate to FT-IR transmission spectroscopy.</p></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/two-complementary-nanoscale-ir-techniques-photothermal-afm-ir-and-s-snom.html"><strong>watch part 1: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/nanoscale-afm-ir-spectroscopy-and-imaging-for-failure-analysis-of-electronic-devices.html"><strong>watch part 4: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586649600000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote></div></div></div>

Bruker: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR

Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR

This webinar covers numerous academia and industry applications in the field of polymer characterization. 

Nanoscale Chemical Analysis of Polymers with AFM-IR

<div><div><div><div><p><strong>This&nbsp;webinar introduces two main techniques for nanoscale IR measurements: Photothermal AFM-IR (PTIR/AFM-IR) and IR-based Scattering Scanning Nearfield Optical Microscopy (IR s-SNOM).</strong></p><div><div><div><p><strong>The presenter, Dr. Phillips, differentiates AFM-IR and s-SNOM by comparing them to more familiar techniques:&nbsp;</strong>&nbsp;</p><ul><li>AFM-IR is like a nanoscale FTIR</li><li>s-SNOM is like a nanoscale ellipsometry</li></ul><p>Dr. Phillips delves into the fundamentals behind AFM-IR and s-SNOM. Both complementary modes are combined in Bruker’s <a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/products-and-solutions/infrared-and-raman/nanoscale-infrared-spectrometers/anasys-nanoir3-s.html">nanoIR3-s</a> platform.</p><p><strong>Also included in this in-depth introductory webinar are:</strong></p><ul><li>Exemplary case studies for both AFM-IR and s-SNOM</li><li>System configuration descriptions, accompanied by real-machine images</li><li>An extensive Q&amp;A session, where the presenter answers audience questions</li></ul><p><strong>In the Q&amp;A session, viewers can expect to hear the answers to:</strong></p><ul><li>Can AFM-IR be performed in fluid?</li><li>What are typical sample requirements for nanoscale IR techniques?</li><li>What is the probing depth of the laser and that of each technique?</li><li>Can nanoscale IR techniques be performed using a synchrotron source?&nbsp;</li></ul></div></div></div><div><div><blockquote><ul><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/online-demo-of-the-nanoir3-system-photothermal-afm-ir.html"><strong>watch part 2: Online Demo of the nanoIR3 System - Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/chemical-characterization-of-heterogenous-polymeric-materials-on-the-nanoscale-using-photothermal-afm-ir.html"><strong>watch part 3: Chemical Characterization of Heterogenous Polymeric Materials on the Nanoscale Using Photothermal AFM-IR&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/nanoscale-afm-ir-spectroscopy-and-imaging-for-failure-analysis-of-electronic-devices.html"><strong>watch part 4: Nanoscale AFM-IR Spectroscopy and Imaging for Failure Analysis of Electronic Devices&nbsp;</strong></a></a></li><li><a data-g-name="CallToAction" data-protectable="" data-tracking="{&quot;classification&quot;:&quot;default&quot;,&quot;webinarDate&quot;:1586044800000,&quot;onWebinar&quot;:true,&quot;external&quot;:false}" target="_self"><a target="_blank" rel="noopener noreferrer" href="https://www.bruker.com/en/news-and-events/webinars/2020/2d-material-characterization-using-photothermal-afm-ir-and-s-snom.html"><strong>watch part 5: 2D Material Characterization Using Photothermal AFM-IR and s-SNOM&nbsp;</strong></a></a></li></ul></blockquote><blockquote><p><strong>Presenter: </strong>Cassandra Phillips, Ph.D. Bruker expert&nbsp;</p></blockquote></div></div></div></div></div></div>

Bruker: Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM

Two Complementary Nanoscale IR Techniques: Photothermal AFM-IR and s-SNOM

This webinar introduces two main techniques for nanoscale IR measurements: PTIR/AFM-IR and IR s-SNOM

AFM-IR & s-SNOM: Two Complementary Nanoscale IR Methods

<p><strong>INVENIO is Bruker’s next generation and fully upgradeable FT-IR platform from sophisticated routine to advanced research applications.</strong>&nbsp;</p><p>The new INVENIO X with patented INTEGRAL<sup>TM</sup>&nbsp;interferometer represents the multispectral range R&amp;D spectrometer with the world’s highest degree of automation. Combining the pioneering 5x MultiTect technology and the INTEGRAL<sup>TM</sup>&nbsp;interferometer with integrated automatic 3x beam splitter changer provides unmatched flexibility and performance for advanced R&amp;D applications.</p><p>A long list of further smart features, such as the additional Transit<sup>TM</sup>&nbsp;sample compartment, the flexible high performance optics path with up to 7 internal detectors, electronically coded windows, optional embedded touch panel with dedicated software and many more.&nbsp;</p><p>With this webinar we will provide you an overview of the INVENIO R&amp;D capabilities including many interesting application examples.</p>

Bruker: Fully automated multispectral range FT-IR R&D spectrometer

Fully automated multispectral range FT-IR R&D spectrometer

With this webinar we will provide you an overview of the INVENIO R&D capabilities including many interesting application examples.

<div><div><div><div><div><div><div><div><div><p><strong>The need for high-resolution techniques is regarded as being urgent for Higher Order Structure (HOS:secondary, tertiary and quaternary structure) comparability and similarity assessment. Recently, new developments in acquisition and data analysis have emerged to establish NMR as a powerful tool for HOS characterization of intact molecules at natural abundance.</strong></p><p>The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses (characterization for comparability/similarity) will be presented. Fast 1D fingerprinting methods will give a quick answer if a batch is comparable to another or to the reference material. To identify changes at the amino acid level, 2D NMR methods are required. Results obtained from three real case studies will be discussed: a nanobody (40 kDa molecule in simple buffer) and two recombinant mAbs in a complex buffer (142 kDa and 177 kDa, respectively).</p><p>There is no single solution to the problem of evaluation of HOS. Techniques typically used for HOS characterization (CD, HDX-MS, fluorescence, FT-IR, thermal analysis by NanoDSC) measure different aspects of structure, either directly and indirectly. NMR offers superior resolution, sensitivity, and characterization of multiple structural aspects with a single experiment.</p><p><strong>What You Will Learn</strong></p></div><div><div><div><div><div><div><ul><li>How NMR provides a solution to the need for Atomic Resolution in HOS characterization;</li><li>How NMR can be applied to intact molecules at natural abundance, with acquisition times reasonable for routine analysis;</li><li>How NMR is a high precision analytical technique and produces data that is the ideal input for robust statistical tools required for HOS evaluation;</li></ul><p><strong>Who Should Attend</strong></p><p>This webinar will be of interest to those involved in the development and manufacturing of biologics and biosimilars, especially in their analysis, testing and quality control - analytical R&amp;D, QC, QA scientist and leaders seeking to enhance and optimize their analytical capabilities with cutting-edge, information-rich technology. Also relevant for academics developing analytical methods for the study of therapeutic drugs and those working in close collaboration with the biopharmaceutical industry.</p><blockquote><p><strong>Presenter: </strong>Dr. Fabio Baroni (Associate Researcher - Protein Chemistry Department – Physico-Chemical characterization Lab - Merck Serono S.p.A. - Guidonia Montecelio (Roma))</p><p>Dr. Fabio Baroni, biotechnologist by education, holds a PhD in structural biology from the University of Parma (Italy). He is specialized on NMR and spectroscopic techniques applied to protein characterization. In May 2017 he joined Merck Serono as associate researcher, in the Protein Chemistry Department (Rome site, Italy).</p><p><strong>Presenter: </strong>Dr. Christian Fischer (Product Manager of AssureNMR and BiologicsHOS - Senior Staff Scientist, MRS Application Development - Bruker BioSpin GmbH)</p><p>Dr. Fisher has a degree and a PhD in Chemistry from the University of Düsseldorf, Germany. He then joined Bruker in 1999 in the NMR Software Development group. After working on mixture analysis products, he moved into the MRS Application Development. Now he is Product Manager of AssureNMR and BiologicsHOS.</p></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Bruker: Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

Evaluation of Higher Order Structure of Biologics at Atomic Resolution using NMR

The application of 1D and 2D NMR of the intact molecule at isotope natural abundance to routine analyses will be presented.