Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies, LECO and Shimadzu and technical note by Thermo Fisher Scientific!<h3>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</h3>Fast, accurate AOAC compliant food analysis using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 ICP-QQQ</a> with AVS MS and ADS 2&nbsp;<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf">Full PDF for download</a>&nbsp;</li></ul>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500">Agilent 9500 Triple Quadrupole ICP-MS</a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.<h4>Conclusion&nbsp;</h4>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;<ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.<h3>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf">Full PDF for download</a></li></ul>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.<h4>Instrument Model and Configuration&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883">LECO C832</a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO2.<h4>Typical Results&nbsp;</h4>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.<h3>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050">Shimadzu ICPMS-2050</a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.<h4>Conclusion</h4>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.<h3>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf">Full PDF for download</a></li></ul>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992">Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</a> (shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;<ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

Acne is one of the most common skin conditions. It affects up to 85% of people during adolescence and, for many, persists into adulthood. Beyond its physical symptoms, it can also significantly affect self-confidence. Treatment often takes time, and some commonly used products can dry out or irritate the skin. Researchers at CEITEC Brno University of Technology (BUT) have developed specially modified cellulose microfibres that effectively inhibited acne-causing bacteria in laboratory tests. The fibres can be used in face masks. These findings could pave the way for new approaches to treating&nbsp;acne-prone skin.The material consists of cellulose acetate microfibres enriched with zinc oxide and subsequently treated with oxygen plasma. The zinc oxide is then gradually released into the skin, where its antibacterial action limits the growth of bacteria associated with acne. Unlike conventional products, the active ingredient is incorporated directly into the fibres and released gradually, allowing for a longer-lasting effect.“The fibres retain high efficacy without any of the additives commonly found in commercial products. The material contains exactly what is needed to combat acne effectively, with no unnecessary ingredients. Our research showed that the fibres retain their antibacterial effect for at least a year after treatment,” says Martina Říhová of the Advanced Low-Dimensional Nanomaterials research group at CEITEC BUT, who led the research. This demonstrated long-term effect opens the door to commercial applications.In the future, the same principle could also be used to treat other skin conditions complicated by bacterial infections, such as atopic dermatitis. The fibres could be incorporated not only into face masks for acne treatment but also into patches for smaller affected areas or dressings suitable for larger areas.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová from CEITEC BUT during face skin analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_2_1be8944b43.jpeg 235w," sizes="100vw" width="1600" height="1067"><h3>Fibres Made Much Like Cotton Candy</h3>The researchers produced the microscopic fibres using centrifugal spinning. The same physical principle is used to make cotton candy, but in this case, fine polymer fibres are formed instead of sugar strands.The breakthrough came from combining a method called Vapour Phase Infiltration, which enriched the fibres with zinc oxide, with subsequent oxygen plasma treatment. This treatment slightly disrupts the surface of the fibres, allowing the active substances to be released upon contact with water.“We were the first in the world to demonstrate this procedure using cellulose acetate fibres,” notes Martina, who has been researching acne and its treatment for seven years. She and her colleagues published their <a target="_blank" rel="noopener noreferrer" href="https://www.researchgate.net/publication/403127590_Cellulose_Acetate_Fibers_With_Infiltrated_ZnO_Nanocrystals_Activation_of_Antibacterial_Properties_Against_Acne_vulgaris_by_Oxygen_Plasma_Treatment">findings</a> in Small, one of the world’s leading scientific journals focusing on nanomaterials and nanotechnology.<h3>Researchers from Brno and Spain Joined Forces</h3>Several research teams from different institutions contributed to the material’s development. “Our team, led by Jan Macák, was responsible for preparing the fibres. We then took them to San Sebastián in Spain, to Mato Knez’s team at nanoGUNE, where they carried out the vapour phase infiltration. Next, Lenka Zajíčková’s team at CEITEC BUT treated the fibres with oxygen plasma. Finally, Zbyněk Heger’s team at the Department of Chemistry and Biochemistry at Mendel University conducted the antibacterial testing,” says Martina Říhová, describing the collaboration.The research took more than a year. Before the new material can enter routine use, it will need to undergo further biological testing, followed by clinical trials to verify its safety and effectiveness in treating patients.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg" alt="CEITEC BUT/Jakub Rozboud: Technology Inspired by Cotton Candy Could Help Treat Acne: Martina Říhová's microfibres developped for acne treatment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_K_lecbe_akne_muze_pomoci_technologie_inspirovana_vyrobou_cukrove_vaty_3_b21c60ae29.jpeg 235w," sizes="100vw" width="1600" height="1067"><blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.researchgate.net/publication/403127590_Cellulose_Acetate_Fibers_With_Infiltrated_ZnO_Nanocrystals_Activation_of_Antibacterial_Properties_Against_Acne_vulgaris_by_Oxygen_Plasma_Treatment">Cellulose Acetate Fibers With Infiltrated ZnO Nanocrystals: Activation of Antibacterial Properties Against Acne vulgaris by Oxygen Plasma Treatment</a></h4>Martina Rihova, Denisa Fenclova, Pavan Kumar Chennam, Aniket Mukherjee, David Pavlinak, Susan Azpeitia, Kristyna Cihalova, Miloslav Pouzar, Kaushik Baishya, Lenka Zajíčková, Zbynek Heger, Mato Knez, Jan M. MacakSmall, 2026, 22, e13286<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/smll.202513286?urlappend=%3Futm_source%3Dresearchgate.net%26utm_medium%3Darticle">10.1002/smll.202513286</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>In this work, we developed biodegradable cellulose acetate (CA) fibers infiltrated with ZnO nanocrystals for the Acne vulgaris (AV) treatment. The antibacterial effect (through Zn²⁺ release) was activated upon oxygen plasma treatment. CA fibers (fiber diameter ≈ 2 µm) were produced via centrifugal spinning, followed by ZnO infiltration (up to 8 wt% of Zn content) using Vapor Phase Infiltration (VPI) with varying deposition cycles. As CA fibers are naturally hydrophobic, oxygen plasma treatment was applied to turn them hydrophilic and to improve skin wetting. The combination of these steps is presented for the first time.Plasma treatment introduced oxygen‐containing functional groups on the CA surface, significantly improving wettability. Scanning electron microscopy analyses of treated fibers showed no morphological damage. Detailed characterization (using X‐ray photoelectron spectroscopy, Raman spectroscopy, energy dispersive X‐ray fluorescence, X‐ray diffraction, tranmission electron microscopy) focused on fibers with 32 and 128 VPI cycles, revealed that plasma partially oxidized and etched the surface, affecting the ZnO distribution.Plasma‐modified fibers, unlike untreated ones, exhibited antibacterial activity against AV‐causing bacteria (Cutibacterium acnes and Staphylococcus epidermidis), creating significant inhibition zones (up to 5 mm), demonstrating their potential as promising therapeutic modality. Overall, plasma treatment enabled effective surface functionalization, producing antibacterial fibers with enhanced surface properties suitable for application in AV management.

Technology Inspired by Cotton Candy Could Help Treat Acne

Proper care and maintenance of HPLC columns are essential for getting accurate results and saving on replacement costs. Extending the HPLC column life not only ensures consistent performance but also reduces downtime and the need for frequent replacements.Routine maintenance is equally essential for sustaining column functionality. Correct handling of the column is paramount, ensuring strict compliance with the manufacturer’s specifications regarding pressure, pH, flow rate, and temperature.In the next section, we will explore these best practices in greater detail, offering further guidance on essential HPLC column maintenance strategies. Whether you’re working in a high-throughput lab, or conducting occasional analyses, these strategies will help you get the most out of your <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=48&amp;manufacturerItems=50">HPLC columns</a>.<h3>Essential Guidelines for Extending HPLC Column Life</h3>By adopting these simple yet effective practices, you can greatly extend the HPLC column life while ensuring reliable, high-quality results in your analyses.<h4>Proper Column Handling</h4>HPLC columns should be handled with care to prevent physical damage or shock. The pump should not be started at high flow rates; instead, the flow rate should be gradually increased over several minutes. A pump pressure limit should be set to protect the column from over pressuring, as sudden pressure changes can lead to voids, negatively affecting the column’s performance.<h4>HPLC Column Conditioning and Equilibration</h4>Conditioning is a critical step for preparing a new or stored HPLC column by replacing the storage solvent with the desired mobile phase. Care must be taken to avoid introducing immiscible solvent mixtures into the column. Universally miscible solvents such as THF (tetrahydrofuran) or IPA (isopropyl alcohol) can be useful for this process when moving from normal phase to reversed phase solvent systems. Care must also be taken to ensure that solvents that may be damaging to a specific stationary phase are avoided.For example, if a reversed-phase column experiences phase collapse due to 100% aqueous mobile phases, it should be reactivated. This process involves running 100% acetonitrile at a high flow rate and a temperature as high as 60°C. It is essential to ensure no solid buffers precipitate from residual solvents. Depending on the column condition, between 50 and 100 column volumes are needed for complete reactivation and equilibration, restoring the column’s efficiency for future use.<h4>Optimizing Operating Conditions</h4>Optimizing operating conditions is paramount to enhancing HPLC column efficiency and prolonging their operational lifespan. A fundamental aspect of this is strict adherence to the manufacturer’s recommended temperature, pH and pressure parameters.Deviating from these limits, particularly by operating at elevated temperatures, can significantly hasten the degradation of the stationary phase and hardware, thereby compromising overall performance. Elevated temperatures can also narrow the pH operating range, exacerbating the risk of column degradation through phenomena such as peak broadening or diminished efficiency.Effective pressure management is equally crucial. Sudden pressure surges or mechanical shocks can result in bed voiding, leading to poor chromatographic performance, such as split peaks and reduced separation efficiency. Gradual ramping of flow and pressure, implemented each time the column is initiated, mitigates these risks. Many modern HPLC systems are equipped with automated flow-pressure ramping capabilities, ensuring smoother transitions and reducing the potential for column damage.In addition, vigilant monitoring of the mobile phase's pH is vital to the maintenance of HPLC column integrity. Deviations from the optimal pH range can cause significant harm to the stationary phase. For instance, leads to ligand hydrolysis which leads to a loss of stationary phase functionality and diminished column performance over time. High pH can lead to silica degradation. This weakens the silica structure, causing particle dissolution, void formation, and loss of column efficiency. Maintaining the pH within optimal boundaries is essential for preserving the column’s structural integrity and ensuring consistent chromatographic performance.Furthermore, incorporating inline filters and guard columns into the system serves as a proactive measure to prevent particulates and harsh sample matrices from damaging the analytical column. These preventive tools significantly enhance operational conditions and safeguard the column from contamination, ultimately contributing to extended HPLC column lifetime and reliable performance.<h4>Regular Column Maintenance</h4>Effective routine maintenance is paramount to extending the HPLC column lifetime and ensuring the consistent performance of HPLC columns. A critical aspect of this maintenance is the thorough washing of the column after each use to eliminate residual sample components and mobile phase contaminants.The cleaning process generally involves performing an isocratic or gradient wash using a solvent system similar to the one previously used on the column but substituting the buffer with HPLC-grade water. This helps effectively remove any residual buffer components from the column. This meticulous cleaning process is vital to preventing the accumulation of impurities that could compromise the stationary phase and lead to decreased efficiency over time.Post-cleaning, it is imperative to end-cap the column before storage to prevent the stationary phase from drying out, a condition that can negatively impact the column’s future performance. Proper capping or sealing ensures that the column remains in optimal condition, safeguarding its structural integrity and readiness for subsequent analyses.Additionally, utilizing an older HPLC system as a dedicated wash station can further streamline maintenance practices, freeing up live systems for active use. Consistently adhering to a rigorous cleaning and storage regimen not only enhances the longevity of HPLC columns but also guarantees the delivery of precise and reliable analytical results.For severe contamination or pressure buildup, backflushing may be necessary to dislodge tightly bound contaminants. However, backflushing should only be performed when absolutely necessary, as it can stress the column packing material. It is essential to consult the manufacturer’s instructions before attempting this method.

How to Extend the Lifetime of HPLC Columns?

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Agilent Technologies

In ICP-OES method development, wavelength selection based on sensitivity, freedom from spectral interferences, and linearity is the foundation upon which quality data is built.
Taking the time to investigate multiple wavelengths for a given element will yield the most accurate analytical results. During this webinar, several important features and tools for method development will be shown in the ICP Expert software, including a feature called IntelliQuant. IntelliQuant is an included feature of the ICP Expert software, and is a semi-quantitative analysis based on a supplied calibration. This feature, along with others which will be shown, makes method development with the Agilent ICP-OES simple and easy.
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Presenter: Tina Harville (Online Applications Advisor, Agilent Technologies, Inc.)
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Tina R. Harville has spent her career working in atomic spectrometry. She graduated from Clemson University with a Ph.D. in Analytical Chemistry where her research focused on Radio-Frequency Glow Discharge Atomic Emission Spectrometry (RF-GD-AES). After graduate school, she began her career as an ICP-OES development chemist at Alfred H. Knight Laboratories in South Carolina. Then she went to NJ where she worked both as an ICP-OES and RF-GD-AES applications chemist for JY/HORIBA. She later came back to the south to work at Varian, Inc. in Cary, NC as a Dissolution Product Specialist and then quickly joined the atomic team as an applications chemist. For seven years, she was an applications engineer for Agilent, supporting both Flame and Furnace AA, MP-AES and ICP-OES. Two years ago, she joined the Technical Support Team at Agilent, where she is currently an Online Applications Advisor.
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Agilent Technologies: Method Development Tips for ICP-OES: Wavelength Selection Considerations for Optimal Sensitivity and Linearity

Method Development Tips for ICP-OES: Wavelength Selection Considerations for Optimal Sensitivity and Linearity

Several important features and tools for method development will be shown in the ICP Expert software, including a feature called IntelliQuant.

Method Development Tips for ICP-OES

Agilent’s semi-quantitative feature, IntelliQuant, is a powerful tool for rapid sample screening without even building a quantitative method.
Maximize the benefits of IntelliQuant for research and development, building challenging methods, looking for interferences and troubleshooting. Learn how to customize IntelliQuant calibration and results to fit your needs.
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Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
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Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
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Agilent Technologies: Know What’s in Your Sample Without Quantitative Analysis: The Benefits of Using SemiQuant Analysis on ICP-OES

Know What’s in Your Sample Without Quantitative Analysis: The Benefits of Using SemiQuant Analysis on ICP-OES

Learn how to customize IntelliQuant calibration and results to fit your needs.

Know What’s in Your Sample Without Quantitative Analysis

Demonstration will show steps necessary to implement IEC in your lab to address regulatory requirements.
In addition, data review and comparison will be conducted using the multiple background correction techniques to show advantages of Agilent-patented Fitted Background Correction and FACT over traditional off-peak background correction.
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Presenter: Greg Gilleland (Application Scientist, Agilent Technologies, Inc.)
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Greg began his spectroscopy career in 1987 in Colorado, working at a series of environmental labs. After 14 years working in the world of commercial environmental labs, he moved on to a spectroscopy instrument manufacturer where he performed service and sales functions over the course of 11 years. He has been with Agilent Technologies, Inc., since 2012 in the role of Application Scientist for ICP-OES, MP-AES and AA products.
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Agilent Technologies: IEC Implementation and Alternate Spectral Interference Techniques on the Agilent 5110 ICPOEs

IEC Implementation and Alternate Spectral Interference Techniques on the Agilent 5110 ICPOEs

Steps necessary to implement IEC in your lab to address regulatory requirements.

IEC Implementation and Alternate Spectral Interference

Iron-containing compounds can be problematic during the refinery of petrochemicals or the manufacture of semiconductor devices.
These Iron compounds, including particles, can lead to corrosion of refinery equipment, adversely affecting the petroleum value chain. In the semiconductor industry, Fe Nanoparticles (NPs) can lead to cone defects on the surface of wafers, which cause shorting of electrical signals. Single particle inductively coupled plasma mass spectrometry (spICP-MS) is increasingly used to study NPs. Currently, most studies have focused on NPs in aqueous sample matrices, with few studies on nonaqueous matrices. One of the issues for this is the lack of hydrocarbon matrices, and solvent-compatible reference nanomaterials (RMs) to validate new methods. Two gold (Au) polystyrene-coated NP RMs in toluene and silica-shelled iron oxide (Fe3O4) alkylsilane-modified NPs in o-xylene were synthesized. spICP-MS and transmission electron microscopy (TEM) were integral to developing and characterizing the standard materials.
In this talk, we will share the spICP-MS method on the Agilent 7900 ICP-MS used to characterize the synthesized Au and Fe NP RMs. NIST crude oil standard reference material (SRM) and a NIST residual fuel oil SRM were also measured for the natural Fe NP content and spiked Fe NP content. 
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Presenter: Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)
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Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Chemist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at University of California, Davis since 2013. Jenny has been very active with AOAC and ASTM over the past 8 years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry.
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Presenter: Mark Kelinske (Application Scientist, Agilent Technologies, Inc.)
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Mark Kelinske is an Applications Chemist with Agilent Technologies, specializing in advanced ICP-MS and ICP-MS/MS techniques. He received his undergraduate and graduate degrees from Texas A&amp;M University in College Station, TX. Prior to Agilent, Mark was a senior research scientist and research group manager with Southern Research Institute in Birmingham, AL, where he focused on low-level analytical chemistry, method development, and research program management.
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Agilent Technologies: Characterization of Synthesized Iron Nanoparticles in Hydrocarbon Matrices by Single Particle (sp) ICP-MS

Characterization of Synthesized Iron Nanoparticles in Hydrocarbon Matrices by Single Particle (sp) ICP-MS

The spICP-MS method on the Agilent 7900 ICP-MS used to characterize the synthesized Au and Fe NP RMs. NIST crude oil standard reference material (SRM).

Characterization of Synthesized Iron Nanoparticles

A new innovation for the Agilent ICP-MS single and triple quad ICP-QQQ models is the M lens.
We will discuss how the M lens works and its applications within the semiconductor industry.
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Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
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Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
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Agilent Technologies: Agilent M Lens for ICP-MS and the Semiconductor Industry

Agilent M Lens for ICP-MS and the Semiconductor Industry

How the M lens works and its applications within the semiconductor industry.

Single particle ICP-MS (spICP-MS) sizes and counts particles as small as sub-10 nm at ultra-trace levels.
It has been widely accepted as a powerful tool in many fields of study, for example single cell analysis by mass cytometry or CyTOF, environmental and industrial nanotoxicology. Its superb sensitivity and selectivity often distinguish it from other particle analysis techniques for many applications. This presentation will cover two recently developed applications in two critical semiconductor processes, ultrafiltration and chemical mechanical planarization (CMP). spICP-MS demonstrated its ability to advance the metrology to measure, for the first time, some important attributes of these processes. For example, spICP-MS successfully measured size-exclusion retention of nanoparticles by ultrafiltration membranes , and it also quantified the size changes of ceria nanoparticles before and after CMP processes . The fundamentals and applications will be discussed in more detail in the presentation.
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Presenter: Charlie (Qilin) Chan (Advanced Research Specialist, PhD, PMP, 3M Corporate Research Analytical Laboratory)
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Qilin Chan is an advanced research specialist at 3M. He is the corporate leader for elemental analysis technology. His current research interests include developing new analytical methods to solve problems in new technology and product development in the fields of semiconductor and biopharma processes. Qilin is a part-time student studying data science at Georgia Institute of Technology. He obtained his Ph.D. in 2011 from University of Cincinnati where he studied metalloproteins and their regulations under stress in plant and animal models. He is an author of 24 peer-reviewed journal publications.
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Presenter: Jenny Nelson (Application Scientist, Agilent Technologies)
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Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Scientist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at the University of California, Davis, since 2013. Jenny has been very active with AOAC and ASTM over the past eight years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry. Jenny has extensive experience in operating and method development for Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Microwave Plasma Atomic Emission Spectroscopy (MP-AES). Jenny has broad knowledge and experience in different speciation analysis for many sample matrices using GC-ICPMS and LC-ICPMS. As well as vast experience with sp-ICP-MS for many applications.
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Agilent Technologies: Single Particle ICP-MS Applications in Advanced Semiconductor Processes

Single Particle ICP-MS Applications in Advanced Semiconductor Processes

Two recently developed applications in two critical semiconductor processes, ultrafiltration and chemical mechanical planarization (CMP).

Single Particle ICP-MS Applications

Automatic determination of ionic and nanoparticle contamination in semiconductor process chemicals and on silicon production wafers has become increasingly important.
Elemental Scientific offers a wide range of products to monitor contamination in semiconductor materials. ScoutDX enables online, automated determination of single digit and sub-ppt ionic contamination in a wide range of process chemicals at greater than 300m distances. ScoutNANO adds the capability to perform automated nanoparticle determination, reference material calibration, and hardware for long-term nanoparticle solution stability. RadianVPD is a high speed VPD system for determining on-wafer contamination, offering the highest throughput VPD system available with a wide range of options for both production and R&amp;D environments.
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Presenter: Kyle Uhlmeyer (RadianVPD Applications Manager, Elemental Scientific)
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Kyle Uhlmeyer is the RadianVPD applications manager for Elemental Scientific. He has been with ESI for more than 10 years, and worked on a wide range of projects. In the past 5 years he has helped develop, install, and support semiconductor products such as ScoutDX, prepFAST S, and RadianVPD.
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Presenter: Austin Schultz (Project Engineer, Elemental Scientific)
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Austin Schultz is a project engineer for Elemental Scientific. In his 10 years at ESI he has helped develop products ranging from hydride generation to inline-autodilution to low viscosity sample transfer, he specializes in ultrapure chemical analysis for semiconductor customers.
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 Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
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Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
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Agilent Technologies: Automated Online Semiconductor Monitoring with ScoutDX, ScoutNANO, and RadianVPD

Automated Online Semiconductor Monitoring with ScoutDX, ScoutNANO, and RadianVPD

Elemental Scientific offers a wide range of products to monitor contamination in semiconductor materials.

Automated Online Semiconductor Monitoring

This will be a three week Food and Cannabis elemental analysis workshop.
We will cover a lot of great information during these three weeks.
Part 1: We will cover the entire Agilent elemental portfolio. Each of the different instruments&#39; strengths and how they meet the challenges that food and cannabis labs have.
Part 2: We will focus on preparing your samples, including microwave digestion. We will also cover how to optimize your system for high matrix samples and a diverse sample set.
Part 3: We will put it all together, with running samples live in the lab. We will also share additional tips and tricks on obtaining excellent analytical results in these difficult matrices.
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Presenter: Jenny Nelson, PhD (Application Scientist, Agilent Technologies, Inc.)
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Jenny Nelson received her Ph.D. in Analytical Chemistry from the University of Cincinnati in 2007, and her MBA from Saint Mary’s College of California in 2011. Currently, Jenny is an Application Scientist for the Life Science and Chemical Analysis team at Agilent Technologies, joining in 2012 (with a step away in 2019). Jenny is also an Adjunct Professor in the Department of Viticulture and Enology at the University of California, Davis, since 2013. Jenny has been very active with AOAC and ASTM over the past eight years, serving on expert review panels, chairing committees, and volunteering to develop new methods needed by the industry. Jenny has extensive experience in operating and method development for Inductively Coupled Plasma Mass Spectroscopy (ICP-MS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Microwave Plasma Atomic Emission Spectroscopy (MP-AES). Jenny has broad knowledge and experience in different speciation analysis for many sample matrices using GC-ICPMS and LC-ICPMS. As well as vast experience with sp-ICP-MS for many applications.
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Presenter: Greg Gilleland (Application Scientist, Agilent Technologies, Inc.)
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Greg began his spectroscopy career in 1987 in Colorado, working at a series of environmental labs. After 14 years working in the world of commercial environmental labs, he moved on to a spectroscopy instrument manufacturer where he performed service and sales functions over the course of 11 years. He has been with Agilent Technologies, Inc., since 2012 in the role of Application Scientist for ICP-OES, MP-AES and AA products.
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Presenter: Mark Kelinske (Application Scientist, Agilent Technologies, Inc.)
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Mark Kelinske is an Applications Chemist with Agilent Technologies, specializing in advanced ICP-MS and ICP-MS/MS techniques. He received his undergraduate and graduate degrees from Texas A&amp;M University in College Station, TX. Prior to Agilent, Mark was a senior research scientist and research group manager with Southern Research Institute in Birmingham, AL, where he focused on low-level analytical chemistry, method development, and research program management.
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Presenter: Chris Conklin (Atomic Spectroscopy Product Specialist, Agilent Technologies, Inc.)
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With a degree from the University of Wisconsin – Eau Claire, Chris worked in, and lead, a quality control lab testing fine chemicals ranging from reagent grade to high purity. Over the course of 12 years in that role, Chris has run a variety of atomic elemental instruments and techniques including AA, ICP-OES, and ICP-MS. As a result, he has seen most of the periodic table in its elemental form and overcome the associated interferences. In 2018, Chris brought that knowledge and experience to his current role with Agilent as the Product Specialist for Atomic Spectroscopy supporting AA, MP-AES, and ICP-OES for the Eastern US.
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Agilent Technologies: Food and Cannabis Elemental Analysis Part 1: Elemental Workflows in the Food and Cannabis Lab

Food and Cannabis Elemental Analysis Part 1: Elemental Workflows in the Food and Cannabis Lab

Agilent elemental portfolio. Each of the different instruments' strengths and how they meet the challenges that food and cannabis labs have.

Food and Cannabis Elemental Analysis Part 1

Agilent Applications Scientists will demonstrate on live 8900 Triple Quad ICPMS and 5900 ICPOES instrumentation, the hardware, MassHunter and ICP Expert software as well as tuning and cleanliness strategies used and recommended in semiconductor facilities to reduce contamination, maximize sensitivity and minimize interferences.
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Presenter: Bert Woods (Application Scientist, Agilent Technologies, Inc.)
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Joined the Agilent ICP-MS team in 2004, with previous employment in the semiconductor industry with Dominion Semiconductor (IBM/Toshiba) and Micron. Bert is a 1997 Chemistry graduate of Radford University in Virginia and an avid Washington DC Sports fan.
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Presenter: Emmett Soffey (ICP-MS Product Specialist, Agilent Technologies, Inc.)
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Emmett Soffey is an ICP-MS Product Specialist and has been with HP/Agilent for 30 years. He received his undergraduate degree from Cornell University. Prior to Agilent he worked at Brookhaven National Labs studying acid rain in the Adirondack Mountains of northern NY and then went on to work at a number of commercial analytical labs operating GC and GC/MS. Emmett has been part of the Agilent ICP-MS team since 1995. He has worked on the development of new software tools, discrete sampling devices and the GC-ICP-MS interface. In his spare time Emmett spends time hiking in the beautiful Cascade Mountains of Washington State.
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Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
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Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
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Presenter: Chris Conklin (Atomic Spectroscopy Product Specialist, Agilent Technologies, Inc.)
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With a degree from the University of Wisconsin – Eau Claire, Chris worked in, and lead, a quality control lab testing fine chemicals ranging from reagent grade to high purity. Over the course of 12 years in that role, Chris has run a variety of atomic elemental instruments and techniques including AA, ICP-OES, and ICP-MS. As a result, he has seen most of the periodic table in its elemental form and overcome the associated interferences. In 2018, Chris brought that knowledge and experience to his current role with Agilent as the Product Specialist for Atomic Spectroscopy supporting AA, MP-AES, and ICP-OES for the Eastern US.
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Agilent Technologies: Demonstration of Trace Metals and Electronic Grade Materials Analysis Techniques and Strategies on live Instrumentation.

Demonstration of Trace Metals and Electronic Grade Materials Analysis Techniques and Strategies on live Instrumentation.

8900 Triple Quad ICPMS and 5900 ICPOES instrumentation, the hardware, MassHunter and ICP Expert software as well as tuning and cleanliness strategies.

Demonstration of Trace Metals and Electronic Grade Materials

The semiconductor industry uses a wide range of specialty chemicals in various steps of the manufacturing process.
Analysis and control of the elemental impurities in these reagents are essential for ensuring the integrity of the final product. In this webinar we will discuss how to overcome the challenges of trace level of impurity analysis in challenging matrices on ICP-OES and AA.
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Presenter: Sima Singha, PhD (ICP-OES Application Scientist, Atomic Spectroscopy, Agilent Technologies, Inc.)
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Sima has over fifteen years of hands on experience as an applications scientist in the field of atomic spectroscopy. Before joining Agilent in 2017, managed an agricultural chemistry laboratory for the analysis of water, soil, and plant tissue digests using ICP-OES for various EPA methods. She received a Ph.D. degree in Chemistry from the University of Illinois at Chicago with numerous peer-reviewed publications.
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Presenter: Chris Conklin (Atomic Spectroscopy Product Specialist, Agilent Technologies, Inc.)
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With a degree from the University of Wisconsin – Eau Claire, Chris worked in, and lead, a quality control lab testing fine chemicals ranging from reagent grade to high purity. Over the course of 12 years in that role, Chris has run a variety of atomic elemental instruments and techniques including AA, ICP-OES, and ICP-MS. As a result, he has seen most of the periodic table in its elemental form and overcome the associated interferences. In 2018, Chris brought that knowledge and experience to his current role with Agilent as the Product Specialist for Atomic Spectroscopy supporting AA, MP-AES, and ICP-OES for the Eastern US.
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Agilent Technologies: Specialty Chemical Analysis using ICP-OES and AA

Specialty Chemical Analysis using ICP-OES and AA

How to overcome the challenges of trace level of impurity analysis in challenging matrices on ICP-OES and AA.