<div><div>Protons play a central role in many chemical reactions in living organisms. In some cases, a proton may be shared between two nearby molecular groups rather than being localized on just one. This phenomenon can strongly influence the properties and reactivity of biomolecules and is important for enzyme function.</div></div><div>Researchers led by Hanns Christian Schewe (IOCB Prague and Heyrovský Institute of the CAS) together with Lukáš Tomaník (UCT Prague and Fritz Haber Institute of the Max Planck Society) have now investigated proton sharing in a range of biologically relevant polycarboxylic acids dissolved in water, including several molecules related to the citric acid cycle (Krebs cycle).Using liquid-jet X-ray photoelectron spectroscopy (LJ-PES), a technique that reveals the chemical environment of atoms in molecules dissolved in water, the team was able to probe the position of protons on an ultrafast time scale. Unlike techniques such as NMR, which provide a time-averaged picture, photoelectron spectroscopy captures the instantaneous distribution of protons and can therefore distinguish more directly between localized and shared states.The results showed significant proton sharing only in maleic acid dissolved in water. In contrast, protons remained mostly localized at individual carboxylic groups in succinic acid, fumaric acid, malic acid, glutaric acid and citric acid. This suggests that proton sharing is not a common feature of these molecules when they are freely dissolved in water.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Cropped_part_of_the_cover_by_Schewe_et_al_with_the_use_of_Nano_Banana_2_0_2_2a408dbeb5.webp" alt="IOCB Prague: Cropped part of the cover by Schewe et al. with the use of Nano Banana 2.0: Full cover by Schewe et al. with the use of Nano Banana 2.0." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Cropped_part_of_the_cover_by_Schewe_et_al_with_the_use_of_Nano_Banana_2_0_2_2a408dbeb5.webp 117w," sizes="100vw" width="1620" height="2154">The difference appears to be largely controlled by molecular geometry. In maleic acid, the two carboxylic groups are held close together, creating favorable conditions for proton sharing. More flexible molecules can adopt conformations in which the groups are farther apart, while water molecules form strong hydrogen bonds with them and favor localized protons.However, the situation may be different inside proteins. When a carboxylic acid binds in the active site of an enzyme, its shape and position can be tightly constrained. Such an environment could bring the relevant groups close enough together to promote proton sharing and thereby influence enzymatic reactions.The study highlights an important distinction: proton sharing may be rare in freely hydrated molecules but could become important when biomolecules are held in the right geometry by enzymes. It also demonstrates that LJ-PES is a powerful tool for studying proton behavior in solutions. Its ultrafast and site-specific sensitivity could in future help researchers investigate proton sharing directly in more complex chemical and biological systems.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/jaaucr/article/6/6/3349/5084661/Proton-Sharing-in-Polycarboxylic-Acids-in-Aqueous">Proton Sharing in Polycarboxylic Acids in Aqueous Solution</a></h4>Lukáš Tomaník, Jiří Tůma, Gunnar Öhrwall, Ronny Golnak, Ngoc Lan Le Nguyen, Bruno Credidio, Harmanjot Kaur, Petr Slavíček, Bernd Winter, H. Christian Schewe<div>JACS Au, 2026, 6, 3349–3355</div><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/jacsau.6c00377">https://doi.org/10.1021/jacsau.6c00377</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>We investigate proton sharing in biologically relevant polycarboxylic acids in aqueous solutions using liquid-jet X-ray photoelectron spectroscopy. In contrast to techniques that record time-averaged proton positions, like nuclear magnetic resonance, photoelectron spectroscopy captures instantaneous proton distribution due to its ultrafast probing time scale. The method is, therefore, uniquely sensitive to the occurrence of proton sharing in an aqueous environment, as demonstrated here. We only observe significant proton sharing dynamics in maleic acid, where its monoanionic form shows a single, delocalized peak in the carbon 1s spectrum. Conversely, succinic acid, fumaric acid, malic acid, glutaric acid, and citric acid exhibit distinct peaks corresponding to separate, localized COOH and COO– groups, instead of shared protons. Our results reveal that intramolecular proton sharing in water is rather an exception for most biologically relevant polycarboxylic acids. This highlights the importance of enzyme-driven structural changes of polycarboxylic acids associated with proton sharing during metabolic processes.</div>

Proton sharing in polycarboxylic acids in aqueous solution

Autumn has already turned the leaves into vibrant shades, and with the end of the year approaching, we would like to thank you - before the first snowflakes arrive - for your trust, cooperation, and continued interest in our products and services.As a long-standing distributor of Thermo Scientific Finnpipette products, we know that the accuracy and reliability of laboratory results often begin with seemingly small details. Choosing the right pipette and tip is one of the first steps toward a successful analysis.That is why we have prepared an EXCLUSIVE offer to help you replenish your laboratory supplies at a more attractive price, while also thanking you for your continued cooperation and trust.<blockquote>EXCLUSIVE OFFER valid until the end of 2026<ul><li>10% off tips</li><li>10% off pipettes</li></ul>Enter the code “KAŠTANY” in your order or include it in your order e-mail.*For larger orders, an additional discount may be available.</blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/analytika_pipety_a_spicky_thermo_20c5943161.jpg" alt="analytika: Thermo Scientific Pipettes and Tips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_analytika_pipety_a_spicky_thermo_20c5943161.jpg 146w," sizes="100vw" width="1500" height="1605"><h4>LIMITED OFFER WHILE STOCKS LAST</h4><h5>Everything ages. 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Breathomics, Asthma & GC×GC: PH Stefanuto on Fighting the “Proof‑of‑Concept” Trap

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

Our portfolio also includes pipettes and tips, digestors, PFA labware and other equipment for analytical laboratory and trace analysis.

ANALYTIKA

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Anton Paar

Agilent Technologies

Bruker

Malvern Panalytical

Phenomenex

Thermo Fisher Scientific

SelectScience

Waters Corporation

In this presentation, detailed operation of ICP-MS will be discussed, particularly the role of elemental analysis by ICP-MS in the Extractable and Leachable analysis. ICP-MS, with its high sensitivity, wide dynamic range, and ultra-trace multi-elemental detection, is the ideal analytical technique for trace elemental quantification in ICH/USP applications.<blockquote>Presenter: Yan Cheung, PhD (Application Scientist, Agilent Technologies, Inc.)Yan received her Ph.D. in Analytical Chemistry from Indiana University Bloomington. She joined Agilent Technologies as an Application Scientist in the Life Science and Chemical Analysis team in April 2020. Yan has extensive experience in operating and method development in ICP-MS. Yan also has years of experience working in the oil and gas industry.</blockquote>

Agilent Technologies: Trace Metal Determination by ICP-MS in Extractable and Leachable Analysis

Trace Metal Determination by ICP-MS in Extractable and Leachable Analysis

Explore ICP-MS for extractable and leachable (E&L) analysis. Learn ultra-trace elemental quantification for ICH and USP regulatory compliance

ICP-MS for Extractables & Leachables Analysis

PFAS testing laboratories are being asked to do more than ever before. As regulatory requirements evolve and target analyte lists expand, analysts across environmental, food, and materials testing laboratories must deliver reliable trace-level PFAS measurements in increasingly complex applications. In this seven-part mini webinar series, we explore a range of solutions for trace-level PFAS determination, including Feed Injection and large-volume injection techniques, automated sample preparation, direct injection workflows, SPE strategies, thermal desorption, and complementary LC/MS/MS and GC/MS approaches. Each webinar addresses a different aspect of PFAS analysis, providing practical insights into workflow design, method performance, and laboratory productivity.<h4>Session 3: Validated Method for PFAS Testing in Food, Including Meats</h4>Food laboratories face the challenge of detecting PFAS at low concentrations in complex food matrices and demanding analytical requirements. Join this webinar to discover a simplified workflow for analyzing 30 PFAS in food using QuEChERS extraction, Captiva EMR PFAS Food II clean up, and LC/TQ detection.In this mini webinar, discover how to:<ul><li>Analyse 30 PFAS across diverse food matrices</li><li>Simplify extraction and matrix cleanup</li><li>Use Captiva EMR PFAS Food II for effective sample preparation</li><li>Streamline analysis through direct injection</li><li>Achieve the sensitivity, accuracy and precision required for food testing</li></ul><blockquote>Presenter: Peter Kornas (Application specialist LC/MS, Agilent Technologies)Peter has more than 15 years of experience in the development and validation of analytical methods for the determination of pesticides, mycotoxins and contaminants using LC/MS/MS. Before joining Agilent as an LC/MS application specialist in 2018, he worked as an analytical chemist in the food industry. During this time, he was responsible for the development and validation of analytical methods and worked in close coordination with Regulatory Affairs to ensure compliance with the legal requirements of the LC/MS method portfolio.Presenter: Nassima Galloway (Business Development Manager Food &amp; Environmental, Agilent Technologies)Nassima Galloway BSc obtained her degree at Manchester University in Medical Biochemistry BSc. Her professional career began working with environmental laboratories within EMEA offering support on sample preparation solutions and helping laboratories to optimise their workflows throughout.She now holds the position of Business Development Manager for EMEAI within the chemistries supplies division of Agilent Technologies.Nassima works closely within the food &amp; environmental markets to promote the latest advancements in sample preparation techniques and workflow solutions for LC/MS and GC/MS.</blockquote>

Agilent Technologies: PFAS Mini webinar Series

Validated Method for PFAS Testing in Food, Including Meats

Validated workflow for 30 PFAS in food using QuEChERS, Captiva EMR PFAS Food II cleanup, direct injection, and LC/TQ detection.

Validated Method for PFAS Testing in Food

<h4>Empower™ Tips for Audit Trail Compliance</h4>If you are in a regulated laboratory, you may be expected to actively review, interpret, and act on Waters Empower Software audit trail data in order to ensure compliance and data integrity, demonstrate a state of control, and for inspection readiness as part of your overall quality.<h5>In this session you will hear more about:</h5><ul><li>Risk review framework</li><li>Risk event types</li><li>Other items to consider for periodic review</li><li>Streamlining vigilant monitoring</li></ul>Whether you're struggling with defining a risk-based review strategy, interpreting regulatory expectations, or efficiently reviewing audit trails in Empower Chromatography Data System, in this webinar you will walk away with practical methods for structuring efficient, risk-based reviews that surface meaningful events to support patient safety, product quality, and decision-making.<h5>What you’ll gain from this session:</h5><ul><li>Gain insight into what is expected of regulated labs</li><li>Get a practical framework for risk review</li><li>Learn how to simplify audit trail reviews</li></ul>Please join us for a lively discussion as we explore this topic. As always, please bring your questions for this exclusive opportunity to ask our experts anything about Empower Software.<h5>Who should attend</h5>This session is designed for Lab Managers, Empower System Administrators, Quality, Quality IT, and Lab Personnel.Don't miss it!<blockquote>Speaker:&nbsp;Neil Lander (Senior Principal Product Manager, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Senior Principal Product Manager focusing on Informatics solutions.He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives.</blockquote><blockquote>Speaker:&nbsp;Tracy Hibbs (Principal Consulting Marketing Manager, Waters Corporation)Tracy has worked for Waters Corporation since 1999 and has held a variety of positions including Technical Trainer, Business Impact Consultant, Training Manager for Informatics and Data Integrity, and currently, Principal Consulting Product Marketing Manager focusing on Informatics solutions and compliance.Tracy provides support for Waters Empower Software Suite and is concentrated on developing laboratory data management software solutions that help organizations achieve their scientific and operational objectives in regulated environments.Prior to joining Waters, Tracy was a Research Scientist where she gained experience in chromatography and the associated data systems.​</blockquote>

Waters Corporation: Waters Empower Tips - Ask Me Anything About Periodic Audit Trail Review

Waters Empower Tips: Ask Me Anything About Periodic Audit Trail Review

Learn how to streamline periodic Audit Trail reviews in Waters Empower CDS. Implement risk-based frameworks to ensure data integrity and compliance

Periodic Audit Trail Review in Waters Empower CDS

<div><div id="inner_content_body_text" data-content-id="394785">Many laboratories still associate rotational viscometry with large beakers, large sample volumes, and medium-to-high-viscosity materials. But modern cone-plate viscometry changes this picture.In this webinar, we show how low-volume and low-viscosity measurements can be performed with an affordable and easy to use rotational viscometer setup. Using ViscoQC together with the PTD 100 Cone-Plate accessory, laboratories can measure samples from 0.5 mL to 2 mL, control temperature with an integrated Peltier system from 0°C to 100 °C and perform absolute viscosity measurements without the complexity of a research rheometer.The webinar is especially relevant for pharmaceutical, biotech and specialty chemical laboratories working with scarce, expensive, temperature-sensitive or low-viscosity samples. It also benefits users seeking to reduce cleaning effort and shorten measurement turnaround times through low-volume testing, which enables rapid sample temperature equilibration.<h5>Key takeaways:&nbsp;</h5><ul><li>Challenge the beaker mindset: Understand the limitations of conventional beaker-and-spindle viscometry.</li><li>Discover the benefits of cone-plate viscometry: Learn when and why to switch to a cone-plate setup.</li><li>Apply measurement best practices: Master sample handling, spindle and speed selection, and appropriate measurement methods.</li></ul><blockquote>Presenter: Viktor ChristopoulosViktor Christopoulos obtained his PhD in Chemistry from the Technical University of Graz, with a focus on inorganic chemistry. He joined Anton Paar in June 2021 and currently works as a global product manager for viscometers.</blockquote></div></div>

Anton Paar: Viscometers Don't Need 600 mL Beakers - Measure Down to 1 cP with 0.5 mL

Viscometers Don't Need 600 mL Beakers - Measure Down to 1 cP with 0.5 mL

Learn how Anton Paar ViscoQC with PTD 100 enables cone-plate viscometry down to 1 cP using 0.5 mL samples and Peltier temperature control

Low Volume Cone Plate Viscometry with ViscoQC

The increasing focus on ultrashort PFAS, particularly Trifluoroacetic Acid (TFA) and Difluoroacetic Acid (DFA), is creating new analytical challenges for laboratories worldwide. Reliable quantification at trace levels requires a holistic approach that combines regulatory awareness, robust sample preparation, contamination management, optimized chromatography, and sensitive detection.In this webinar, Phenomenex experts will discuss key regulatory drivers, SPE sorbent selection, official PFAS methods, contamination control strategies and the role of delay columns in achieving reliable PFAS measurements.SCIEX experts will present a complete workflow for TFA and DFA analysis demonstrating how advanced LC-MS/MS technology and workflow automation help laboratories achieve ultra-sensitive detection, high throughput, and confidence in TFA and DFA analysis across multiple matrices.&nbsp;<h5>Key Learning Points</h5><ul><li>Understand the regulatory landscape and analytical challenges driving PFAS monitoring, with a focus on food, environmental, and emerging ultrashort-chain PFAS applications.</li><li>Implement robust PFAS workflows through optimized SPE sample preparation, appropriate column selection, and contamination management strategies, including the use of delay columns to improve analytical performance.</li><li>Improve data confidence and laboratory productivity by applying best practices for PFAS identification, quantification, and workflow standardization.</li><li>Address the growing challenge of TFA and DFA analysis using highly sensitive, automated LC-MS/MS workflows that deliver reliable results across multiple matrices with minimal hands-on time.</li></ul><h5>Who should attend:</h5><ul><li>Environmental &amp; Drinking Water Laboratories</li><li>Food Testing &amp; Food Safety Laboratories</li><li>PFAS Analysts &amp; Method Development Scientists</li><li>SPE &amp; Sample Preparation Specialists</li><li>LC-MS/MS Users</li><li>Laboratory Managers &amp; Technical Leaders</li><li>Regulatory &amp; Compliance Professionals</li></ul><blockquote>Presenter: Luigi Margarucci, PhD (EMEA Seminar and Application Lead, Phenomenex)Luigi holds a PhD in Pharmaceutical Sciences and began his career at Phenomenex in 2015 as a Technical Sales Consultant. In 2017, he took on the role of Mass Spectrometry Specialist, followed by Chromatography Training Manager in 2020. Since 2021, he has served as Technical Manager for Italy.He gained extensive experience in chromatography coupled with mass spectrometry while working as a researcher and research fellow at the University of Salerno, collaborating with leading chromatography and mass spectrometry centers in Italy and across Europe, including Utrecht University (The Netherlands).To date, Luigi has authored 27 scientific publications and has written and delivered numerous seminars on analytical techniques such as HPLC, GC, and SPE.&nbsp;</blockquote><blockquote>Presenter: Jianru Stahl-Zeng (Senior Market Development Manager Food, Environmental and Forensics, SCIEX)Jianru has been part of SCIEX since 2001. She initially was part of the application Support team and covered not only proteomics but also small molecules applications. Jianru then moved to technical marketing and focused on Food and Environmental applications.Since 2018, she is managing the EMEAI technical marketing team and projects. Jianru is also the Global Technical Leader for Food and Environmental applications.&nbsp;</blockquote>

Phenomenex: Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

Learn how Phenomenex and SCIEX enable robust PFAS analysis. Master SPE sample prep, contamination control, and LC-MS/MS testing for TFA and DFA

Ultrashort PFAS and TFA Analysis by LC MS MS

PFAS are ubiquitous and detectable at increasingly low concentrations, making sample preparation a critical source of potential contamination. Labware, filtration consumables, and water used for dilutions and blanks can introduce background PFAS, compromising data integrity.Join our experts in this SelectScience® webinar as they explore practical strategies to reduce PFAS contamination in sample preparation for both LC-MS and Total Organic Fluorine (TOF) analysis using combustion ion chromatography (CIC). You will learn how to identify contamination pathways, implement best practices, and select consumables validated for low PFAS background.Sartorius solutions — including Arium® ultrapure lab water systems, Minisart® syringe filters, and Optifit® pipette tips — will be highlighted along with independent testing from Claros Technologies and Novem Scientific demonstrating their performance in LC-MS and TOF workflows.<h5>Certificate of attendance</h5>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.<h5>Webinar details</h5><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 60 minutes</li></ul>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.<h4>Who should attend?</h4>This event is perfect for:<div><ul><li>Analytical chemists</li><li>Analytical lab heads/managers</li><li>Lab managers</li><li>QA and QC managers</li><li>Environmental scientists</li><li>Research scientists</li><li>Environmental lab professionals</li><li>LC-MS/MS-based clinical research professionals</li></ul><h4>What will this webinar cover?</h4><ul><li>Key PFAS contamination pathways and mitigation strategies</li><li>LC-MS vs. CIC/TOF sample preparation considerations</li><li>Independent test results on Sartorius consumables</li><li>How to select and validate consumables</li><li>Practical PFAS quality control strategies</li></ul></div><blockquote>Speaker: Andrew Christianson (President and CEO, Novem Scientific)Andrew Christianson is the President and CEO of Novem Scientific, LLC. He graduated in 2004 from the University of Minnesota, Morris with a BA in Chemistry, emphasis in Biochemistry. He has been serving the scientific industry and solving analytical problems for over 15 years in service and sales of analytical equipment and applications. In addition to being involved in the local Minnesota Chromatography Forum, he is also a voting member on the ASTM D19 water committee.Novem Scientific was founded in August 2021 and specializes in Total Organic Fluorine (TOF) analysis. TOF gives a non-targeted view of the total PFAS contribution in a sample as a compound class, without distinguishing individual analytes. The TOF test has been reimagined with modern instrumentation and Novem is on the cutting edge of research and development in new methods and matrices for this new and demanding analysis space.</blockquote><blockquote>Speaker: Sandra Söderholm, Ph.D. (Application Development Scientist, Sartorius)Sandra Söderholm earned her Ph.D. in Biochemistry from the University of Helsinki in 2016. Before joining Sartorius as an Application Development Scientist in 2019, she worked as a post doc in the field of infection biology at the University of Basel in Switzerland. At Sartorius, she focuses on the development, optimization, and validation of liquid-handling applications, and works with new product innovation, where understanding the customers’ workflows and needs plays a central role.</blockquote><blockquote>Speaker: Dr. Zijie 'Beryl' Xia (Director of Analytical Laboratories, Claros Technologies)Dr. Zijie 'Beryl' Xia is Director of Analytical Laboratories at Claros Technologies Inc., a PFAS destruction company. Since joining Claros in 2020, she has established its ISO-accredited PFAS analytical laboratory. Together with her team, she has developed standard PFAS methods and continues to advance non-standard methods and matrices for novel PFAS analysis.</blockquote><blockquote>Speaker: Klaus Schöne (Scientist, Sartorius)Klaus Schöne is a scientist who has been working at Sartorius, a supplier to the life science industry, since 2005. His work focuses on customer applications and translating application needs into new product solutions, including separation products for laboratory use such as PFAS sample preparation. Further areas of his expertise include the clarification and purification of biomolecules using ultrafiltration and chromatography.</blockquote><blockquote>Speaker: Dr. Kunal Kureja (Product Manager, Sartorius)Dr. Kunal Kureja is a Product Manager at Sartorius AG, specializing in laboratory water technologies and analytical applications. He earned his Ph.D. in Analytical and Preparative Chemistry from the University of Kassel and has worked across academic, startup, and industrial settings. His expertise includes application development, technical communication, and cross‑functional project leadership, with a particular focus on PFAS‑related analytical challenges and contamination risks in laboratory workflows.</blockquote><blockquote>Moderator: Todd Beanlands (Science Editor, SelectScience)</blockquote>

SelectScience: Minimizing PFAS background contamination in sample preparation

Minimizing PFAS background contamination in sample preparation

Learn how to reduce PFAS background contamination during sample prep. Discover Sartorius solutions for clean LC-MS and combustion IC workflows

Minimizing PFAS Contamination in Sample Prep

Sample preparation is one of the most time consuming steps in food and environmental testing. In this session, you’ll learn practical ways to simplify workflows, strengthen method robustness, and prepare your lab for emerging analytical challenges.Our experts will show how to optimize SPE methods, address complex contaminants such as PFAS, and apply simple automation options that increase consistency while reducing hands on time.The webinar will conclude with a Q&amp;A session. Participants will be able to submit their questions through the chat, and our experts will address them at the end.<h4>Key Learning Objectives:&nbsp;</h4><ul><li>Reduce hands on time with streamlined sample prep workflows</li><li>Improve method robustness for routine and advanced analyses</li><li>Accelerate throughput with optimized SPE strategies</li><li>Address complex contaminants, including PFAS, with fit for purpose workflows</li><li>Boost lab consistency using simple automation options</li></ul>Can't attend live? No problem - Register to receive the link to view the on demand recording after the event.You can select the language of the content in the top right corner of your screen.This webinar will be delivered in English.<blockquote>Speaker:&nbsp;Xavier Rodriguez (Principal Applications Specialist, Chemistry, Europe, Waters Corporation)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.</blockquote>

Waters Corporation: From sample to result: advanced sample prep strategies for food and environmental matrices

From sample to result: advanced sample prep strategies for food and environmental matrices

Learn advanced sample prep strategies for food and environmental testing. Optimize SPE, automate workflows, and tackle PFAS contaminants efficiently

Advanced Sample Prep Strategies for SPE and PFAS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>High-resolution accurate mass (HRAM) mass spectrometry has transformed quantitative bioanalysis, opening new possibilities for challenging analytes that have historically pushed the limits of conventional approaches. Join Troy Voelker for a practical look at the evolution of HRAM mass spectrometry for quantitative bioanalysis and how advances in Orbitrap™ technology are helping address increasingly complex analytical challenges.Drawing on more than a decade of experience applying high-resolution mass spectrometry to quantitative workflows, Troy will trace the progression from early studies evaluating whether HRAM could deliver the speed, precision, specificity, and dynamic range required for quantitative analysis to its growing role in modern bioanalysis.The session explores oligonucleotide bioanalysis, including multiple charge states, nonspecific fragmentation, matrix interference, and demanding sensitivity requirements. Troy will share findings from an industry oligonucleotide ring trial and discuss how established methods provided a benchmark for evaluating the next generation of Orbitrap technology, featuring the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer.Attendees will have the opportunity to participate in the live Q&amp;A following the presentation.<h5>Who should attend?</h5>Scientists and laboratory leaders developing quantitative bioanalytical methods using HRAM MS; researchers working with oligonucleotides and nucleic acid therapeutics; and bioanalytical scientists interested in sensitivity, specificity, and quantitative performance.<h5>What you can expect to learn</h5><ul><li>How HRAM MS has evolved for quantitative bioanalysis</li><li>Why charge-state behavior and fragment selection are critical for oligonucleotide LC-MS specificity</li><li>How hybridization sample preparation and HRAM detection can support sensitive workflows</li><li>How Orbitrap Excedion technology can extend sensitivity, speed, and dynamic range</li></ul><blockquote>Presenter: Min Du (Senior Manager, Pharma/BioPharma Applications, Thermo Fisher Scientific)Min Du is the Senior Manager of Pharma/Biopharma Applications for Chromatography and Mass Spectrometry at Thermo Fisher Scientific. With extensive expertise in analytical workflows, she leads teams developing cutting-edge LC-MS solutions. Her work focuses on bioanalysis challenges, RNA oligonucleotide characterization, and advancing therapeutic workflows.Presenter: Troy Voelker (Senior Director of Laboratory Operations, Aliri Bioanalysis)Troy Voelker is an accomplished bioanalytical scientist with more than a decade of experience advancing high-resolution mass spectrometry. His career spans pioneering quantitative HRMS applications to today’s cutting-edge oligonucleotide bioanalysis, with deep expertise in developing methods for complex therapeutics.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Thermo Fisher Scientific: The Groundbreakers Series: Pushing Boundaries 

Advancing Oligonucleotide Bioanalysis with High-Resolution Mass Spectrometry

Join this webinar for a practical look at the evolution of HRAM mass spectrometry for quantitative bioanalysis.

Oligonucleotide Bioanalysis with HRMS

For pharmaceutical companies, elemental analysis is essential for ensuring product quality, process control, and regulatory compliance, but traditional techniques can often create bottlenecks through lengthy sample preparation, high operating costs, and complex workflows. This webinar explores how X-ray Fluorescence (XRF) is transforming pharmaceutical elemental analysis by providing a faster, safer, and more cost-effective alternative for both API and formulation development. XRF enables sample preparation and measurement in under 30 minutes, requires no acid digestion, and can be performed by laboratory technicians with minimal training, helping organizations accelerate decision-making and shorten time-to-market.Join us to discover how XRF supports elemental impurity screening, catalyst residue monitoring, wear metal detection, and ICH Q3D compliance while reducing dependence on hazardous chemicals, costly consumables, and specialized infrastructure. We will compare XRF with conventional ICP-based methods, discuss real-world pharmaceutical applications, and demonstrate how modern XRF solutions can improve laboratory productivity, sustainability, and operational efficiency. Whether you work in pharmaceutical development, manufacturing, quality control, or regulatory testing, this session will provide practical insights into implementing faster elemental analysis workflows without compromising analytical confidence.<h5>Who should attend?</h5><ul><li>Scientists and researchers interested in organic synthesis and understanding reaction mechanisms, byproducts, etc.&nbsp;</li><li>Anyone interested in or working on impurities detection using elemental analysis methods&nbsp;</li><li>Anyone working in Drug substance/product manufacturing and QA/QC</li></ul><h5>What will you learn?</h5><ul><li>Learn how XRF can simplify your elemental analysis&nbsp;</li><li>Discover how XRF can provide meaningful insights and simplify API synthesis process&nbsp;</li><li>Understand why XRF is a reliable technique to be used next to (or instead of) classic elemental analysis spectroscopic techniques</li></ul><blockquote>Speaker: Anoek Nijhuis-Nollen (Application Specialist XRF, Malvern Panalytical)Speaker: Dr. Natalia Dadivanyan (Market Development Manager Pharma Small Molecule, Malvern Panalytical)</blockquote>

Malvern Panalytical: XRF in Pharma: Faster Elemental Analysis for Accelerated Drug Development and Manufacturing

XRF in Pharma: Faster Elemental Analysis for Accelerated Drug Development and Manufacturing

Learn how XRF supports pharmaceutical elemental analysis, impurity screening, catalyst and wear metal monitoring, and ICH Q3D compliance with faster workflows.

XRF for Elemental Analysis of Accelerated Drugs

The compound that binds best isn't always the one that works. Compounds with similar affinity and kinetics often behave very differently downstream — because binding alone doesn't reveal how a molecule reshapes its target.Join us for this live webinar unveiling Molecular Friction Sensing on heliX⁺, a newly published approach for detecting ligand-induced conformational changes in proteins with sub-Ångström resolution under near-physiological conditions. Binding-induced modulation of protein structure is central to how many small-molecule drugs work, yet most screening platforms rely on affinity-based readouts that don't report conformational change. By resolving structural effects independently of affinity or kinetics, Molecular Friction Sensing adds an orthogonal decision-making dimension to hit-to-lead and lead optimization, helping you prioritize the most promising candidates earlier.Presenting the science behind the recently released preprint, this session shows how the assay works, what it reveals, and how it fits alongside your existing biophysical toolkit.<h5>What you'll learn</h5><ul><li>How Molecular Friction Sensing detects ligand-induced conformational changes at sub-Ångström sensitivity</li><li>Why a conformational readout adds information that affinity and kinetic data don't capture</li><li>How to tell apart binders with similar affinities by their effect on protein structure</li><li>Where the assay fits between routine binding assays and classical structural biology</li><li>Results from the preprint, including the characterization of 22 confirmed carbonic anhydrase binders</li></ul><blockquote>Speaker: Prof. Dr. Ulrich Rant (Dresden University of Technology, Kurt Schwabe Institute for Sensor Technologies, Bruker Dynamic Biosensors, Dresden, Germany)</blockquote>

Bruker: See how ligand-induced conformational changes can sharpen compound prioritization

See how ligand-induced conformational changes can sharpen compound prioritization

Learn how Molecular Friction Sensing on heliX⁺ reveals sub-Ångström ligand-induced conformational changes and adds a new dimension to hit-to-lead optimization.

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