Beyond UHPLC: Introducing Extreme Performance Liquid Chromatography with the Nexera X4

As analytical laboratories face increasing sample volumes, more complex samples, and greater demands for efficiency, UHPLC performance can no longer be defined by speed alone. XPLC (Extreme Performance Liquid Chromatography) represents a broader approach to high-performance LC—combining speed, separation, robustness, efficiency, and analytical confidence. In this webinar, we will explore the principles behind XPLC and how advances in low-dispersion design, gradient control, analytical miniaturization, and LC-MS compatibility can help laboratories achieve higher performance without compromising data quality. Using the Nexera X4 as an example of XPLC in practice, we will examine how ultra-sharp peaks, dependable high-speed analysis, reduced solvent consumption, and intelligent workflow capabilities can improve productivity and confidence across demanding analytical workflows. Join us to discover what XPLC means for the future of high-performance liquid chromatography—and how it can help laboratories achieve more without compromise.

Who should attend: 

• Analytical Scientists & Method Developers - Scientists developing and optimizing LC methods who need greater speed, sharper separations, and reliable performance for demanding samples.
• LC-MS & Bioanalytical Scientists - Scientists using LC-MS who want to improve sensitivity, chromatographic efficiency, retention-time reproducibility, and solvent efficiency.
• Laboratory Managers & High-Throughput Laboratory Leaders - Leaders looking to increase laboratory productivity while controlling solvent consumption, operating costs, instrument utilization, and workflow interruptions. 

Learning Objectives:

• Define the XPLC concept and understand how it expands the definition of UHPLC performance - Explore how speed, separation, robustness, efficiency, and analytical confidence come together to create a more complete standard of chromatographic performance.
• Understand how XPLC technologies can improve separation and high-speed analysis - Learn how low-dispersion system architecture and highly stable gradient delivery can enable sharper peaks, improved resolution, and dependable retention-time reproducibility in fast methods.
• Identify opportunities to improve analytical efficiency with XPLC - Explore how analytical miniaturization, reduced solvent consumption, LC-MS compatibility, and intelligent workflow technologies can help laboratories increase productivity while maintaining data quality.

Presenter: Nicholas Lehr (HPLC Product Specialist, Shimadzu Scientific Instruments)

Nicholas Lehr is a Product Specialist at Shimadzu Scientific Instruments with over 6 years of experience in analytical instrumentation, specializing in HPLC, SFC, and molecular spectroscopy. His experience spans technical support, product applications, and customer training, with a focus on helping customers implement and maximize analytical solutions.

Presenter: Kaishi Akazawa (Pharma Market Development Strategist, Shimadzu Scientific Instruments)

Kaishi Akazawa is a Market Strategist at Shimadzu Scientific Instruments, focused on pharmaceutical and biopharmaceutical analytical solutions. With over 14 years of experience at Shimadzu, he works with customers and internal teams to develop analytical strategies and solutions for the pharmaceutical market.