Analytical HPLC strategies across the nucleic acid therapeutics landscape – From ASOs to siRNA to mRNA

Nucleic acid therapeutics such as antisense oligonucleotides (ASOs), siRNA, and mRNA present unique analytical challenges due to their diverse sizes, chemistries, and structural complexities.

In this TechTalk we will explore HPLC-based strategies for the characterization of these emerging therapeutic modalities, highlighting molecule-specific analytical approaches and practical application examples. Particular emphasis will be placed on the use of YMC Accura Triart columns for ion-pair reversed-phase (IP-RP) separations and YMC Accura BioPro IEX columns for anion-exchange (AEX) chromatography.

You will gain an understanding of the key analytical challenges associated with different nucleic acid therapeutics, and will learn how IP-RP and AEX chromatography can be applied to address different analytical questions across the nucleic acid therapeutics landscape.

Certificate of attendance

If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing [email protected].

TechTalk details

• Cost: Free to attend
• Location: Online
• Duration: 20 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.

Who should attend?

This TechTalk is perfect for:

• Analytical development scientists
• Analytical lab heads/managers
• PhD students in analytical sciences
• Post docs in analytical sciences

What will this webinar cover?

• The analytical challenges associated with ASOs, siRNA, and mRNA.
• How to select appropriate HPLC strategies for the characterization of different nucleic acid therapeutics.
• How HPLC methods can be adapted to molecule-specific analytical requirements.

Speaker: Dr. Daniel Eßer (Product Manager Analytical Chromatography, YMC Europe GmbH)

Dr. Daniel Eßer studied chemistry at the University of Applied Sciences Bonn Rhein-Sieg, Germany, specializing in pharmaceutical and analytical chemistry. He earned his PhD in pharmaceutical and medicinal chemistry at the University of Düsseldorf. Following a postdoc establishing nano LC–MS, he joined YMC Europe in 2013 and has served as product manager for analytical chromatography since 2017.