A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range

Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.

A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range

Nucleic acid therapeutics span a wide size range, from short oligonucleotides and siRNA to larger sgRNA, tRNA, and mRNA molecules, creating different chromatographic challenges across workflows. Based on the ISC 2026 poster, this webinar will show how a novel monodisperse supermacroporous reversed-phase platform can provide high-resolution separation across this broad range, with improved impurity resolution, consistent performance, and strong lot-to-lot reproducibility.  The session will also highlight the platform’s broad applicability for routine nucleic acid analysis, including compatibility with volatile ion-pairing conditions for intact RNA characterization, and the benefits of low carryover for routine analytical use.

Key learnings:

• Understand why nucleic acid therapeutics require different analytical solutions across size ranges.
• See how a monodisperse supermacroporous reversed-phase column supports analysis from short oligos to mRNA.
• Learn how the platform improves peak shape, impurity resolution, and selectivity for nucleic acid samples.
• Explore the platform’s compatibility with volatile ion-pairing conditions for intact RNA characterization.
• Review evidence for low carryover and strong lot-to-lot reproducibility.

Audience:

This webinar is intended for scientists and analysts working in biopharmaceutical characterization, method development, oligonucleotide analytics, and RNA analysis.  

If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording. 

Presenter: Matas Damonskis-Roka (HPLC Consumables R&D Manager, Thermo Fisher Scientific)

Matas Damonskis-Rokas is an HPLC Consumables R&D Manager at Thermo Fisher Scientific, focusing on the development of new chromatography products and applications.