RECORD | Already taken place Tu, 7.10.2025
Learn how HILIC-UV/MS and HILIC-ELSD workflows enable robust impurity profiling of GLP-1 agonists like Semaglutide by minimizing adsorption and enhancing recovery.Go to the webinar
Advanced HILIC Workflows for GLP-1 Agonist Impurity Profiling - Session 2
C&EN: Advanced HILIC Workflows for GLP-1 Agonist Impurity Profiling
GLP-1 receptor agonists like Semaglutide and Tirzepatide are complex therapeutic peptides used in treating type 2 diabetes and obesity. Their structural complexity and formulation with diverse excipients pose significant analytical challenges. This webinar will explore impurity profiling and excipient analysis using orthogonal HILIC-UV/MS and HILIC-ELSD workflows.
Attendees will gain insights into mitigating nonspecific adsorption issues and improving method robustness using low-adsorption LC flow paths. The session will also highlight how these workflows complement traditional methods and support regulatory compliance through Analytical Quality by Design (AQbD) principles.
Key Learning Objectives:
- Understand the structural and analytical challenges of GLP-1 receptor agonists.
- Learn how HILIC-UV/MS and HILIC-ELSD workflows enhance impurity profiling.
- Discover strategies to reduce nonspecific adsorption and improve recovery.
Who Should Attend:
- Laboratory Managers
- Chromatographers
- Biopharmaceutical Scientists
- Analytical Chemists
Presenter: Amanda Guiraldelli Mahr, Ph.D. (Senior Scientist, Proteins Chemistry and Separation, RIC Group, Belgium)
