Accelerating Downstream Process Development for Biologics, Gene Vectors and Vaccines

Downstream process development usually requires numerous iterations until optimization is achieved. Offline analytics are often a bottleneck for timely development. The antidote to lagging offline analytics is inline or online process analytical technology (PAT).

Real-time multi-angle light scattering (RT-MALS) is a PAT that monitors fundamental biophysical product attributes like molar mass, size and titer, every second during downstream operations such as FPLC or UF/DF. For AAVs, RT-MALS also monitors the full capsid ratio. This webinar describes the technology of RT-MALS and its implementation with a variety of bioprocess unit operations and modalities, from proteins to viral vectors, LNPs and pneumococcal vaccines.

In this webinar, you will learn:

• What are the CQAs and other attributes determined by RT-MALS for different modalities
• How RT-MALS accelerates bioprocess DSP development
• How process control with RT-MALS can enhance yield and lot consistency

Who Should Attend:

• PAT experts for biologics, vaccines and gene therapies
• Biopharm process development scientists
• Downstream bioprocess engineers
• Biopharm MSAT leaders

Presenter: Dan Some, Ph.D. (Sr. Principal Scientist, Waters | Wyatt Technology)

Dr. Daniel Some is a Sr. Principal Scientist at Waters | Wyatt Technology, where he contributes to product and application development as well as scientific and technical marketing. Currently he leads Wyatt’s program for commercializing real-time MALS PAT products.