Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.<h3>Understanding PFAS and Their Health Impacts</h3>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.<h3>Documented Health Effects</h3>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:<ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul>A 2023 study linked PFAS-contaminated water with up to a 33% increase in cancer incidence in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.<h3>Environmental Persistence and Contamination</h3>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.<h3>Current Detection Methods</h3><h4>EPA Standardized Methods</h4>The Environmental Protection Agency (EPA) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:<h5>EPA Method 533</h5><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe">EPA Method 533</a> focuses on "short chain" PFAS with carbon chain lengths of C4 to C12. Released in December 2019, this method complements Method 537.1 and includes several key features:<ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5>EPA Method 537/537.1</h5><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination">EPA Method 537 </a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:<ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"> solid phase extraction (SPE) </a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul>Together, Methods 533 and 537.1 can detect a total of 29 unique PFAS compounds in drinking water and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].<h5>EPA Method 1633</h5><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633">EPA Method 1633</a>, released in 2024, represents a significant advancement in PFAS analysis:<ul><li>Developed for the analysis of 40 PFAS compounds in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4>Conventional Analytical Techniques</h4>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:<ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.<h4>Emerging Detection Technologies</h4>Several innovative approaches are being developed to address the limitations of conventional methods:<ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.<h3>Challenges in PFAS Detection</h3><h4>Analytical Challenges</h4>Detecting PFAS presents several technical challenges:<ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4>Global Disparities in Detection Capabilities</h4>Access to PFAS detection technology varies significantly worldwide:<ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4>Regulatory Landscape and Compliance</h4>The regulatory framework for PFAS is evolving rapidly worldwide:<ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.<h3>Future Directions in PFAS Detection</h3><h4>Technological Advancements</h4>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:<ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4>Collaborative Approaches</h4>Addressing the global challenge of PFAS detection requires coordinated efforts:<ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3>Conclusion</h3>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.Be sure to check out our other installments of our&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup">Environmental Contaminant Series</a>&nbsp;covering&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops">Persistent Organic Pollutants (POPs)</a>,&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs">Polycyclic Aromatic Hydrocarbons (PAHs)</a>,&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs">Semi-Volatile Organic Compounds (SVOCs)</a>, and <a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs">Polychlorinated Biphenyls (PCBs)</a>.

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

Scientists at CEITEC Brno University of Technology have developed microscopic robots that could one day accelerate beer production and simplify food quality control. The magnetically controlled biobots can actively mix liquids during fermentation, speed up the process, and separate themselves from the finished product once fermentation is complete. The results of the research, carried out by Professor Martin Pumera’s team, were published in the journal ACS Nano.“When people hear the word ‘robot’ today, they often imagine an electronic device. In reality, however, a robot can be any system capable of autonomously performing a specific task,” explains Martin Pumera of CEITEC Brno University of Technology.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg" alt="CEITEC BUT/Jakub Rozboud: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Martin Pumera in his lab at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg 235w," sizes="100vw" width="1600" height="1067">The research team created so-called biobots—biohybrid microrobotic capsules containing brewer’s yeast and magnetic nanoparticles. When the yeast produces carbon dioxide during fermentation, the resulting bubbles cause the biobots to move up and down through the liquid. This naturally mixes the contents of the vessel and makes fermentation more efficient. Compared with conventional static particles, the biobots can therefore accelerate chemical processes that are important in food production.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Hematite microrobot (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg 209w," sizes="100vw" width="1600" height="1192">Another major advantage of the technology is that the biobots can be easily separated from the finished beverage. Thanks to the magnetic particles they contain, they can be controlled with a magnetic field and removed once fermentation is complete, eliminating the need for additional filtration. The researchers also demonstrated that the biobots can be reused over several production cycles.“Unlike conventional static particles, microrobots actively move throughout the entire volume of the liquid, allowing them to cover a larger area and make the whole process more efficient. At the same time, they also facilitate the automation of production,” adds Martin Pumera. The team is currently discussing potential applications of the technology with a major European brewery.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: g-C₃N₄ microrobots (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg 158w," sizes="100vw" width="1476" height="1460">Martin Pumera’s group has long been exploring the use of microrobots and advanced materials in the food industry. In the past, for example, the team developed a flexible sensor for smart packaging capable of detecting spoiled fish. The new biobots therefore represent another step towards more advanced methods of food quality and safety control.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg" alt="CEITEC BUT/ACS Nano: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: ACS Nano - cover featuring article by Martin Pumera et al." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg 117w," sizes="100vw" width="1600" height="2128">

 CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control 

In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with Michelle Taylor, Editor-in-Chief of LabCompare, to go behind the scenes of their groundbreaking two-part documentary series on PFAS (per- and polyfluoroalkyl substances).The conversation kicks off with a startling revelation: many of the world’s leading PFAS experts have completely stopped eating seafood due to high contamination levels discovered during testing. From there, we dive deep into the technical and regulatory challenges facing today's analytical laboratories.<h4>In this episode, we discuss:</h4><ul><li>The Laboratory Throughput Crisis: Why labs are currently "overwhelmed with samples" and how tiered testing—using single quad instruments for screening before moving to triple quads—is helping to manage capacity without sacrificing sensitivity.</li><li>The Battle Against Background Contamination: Why PTFE-free (PFAS-free) laboratory equipment is no longer optional when trying to detect "forever chemicals" at the parts-per-trillion and parts-per-quadrillion levels.</li><li>Complex Matrices (Seafood &amp; Packaging): The technical hurdles of analyzing high-lipid samples like fish and the rising demand for migration testing as states like Rhode Island begin to phase out PFAS in food packaging.</li><li>Global Regulatory Shifts: A look at the "dual compliance model" required for labs supporting international exporters, especially with the European Union’s stricter enforcement compared to the U.S. monitoring approach.</li><li>The "Grand Challenge" of Unknowns: How EPA Method 1621 (Total Organic Fluorine) is helping labs close the mass balance gap and why the next generation of bench chemists must embrace *AI and data science* to manage the massive datasets generated by high-resolution mass spectrometry.</li><li>PFAS Destruction vs. Remediation: &nbsp;The promising (and problematic) methods for breaking the carbon-fluorine bond, and why incineration may inadvertently be spreading shorter-chain PFAS into the air.</li></ul>Whether you are a lab manager looking to future-proof your workflow or a chemist navigating the ever-evolving landscape of EPA Method 1633, this episode provides essential insights into the most pressing environmental crisis of our time.<h3>Video Transcription</h3><h4>Michelle Taylor: PFAS Testing Is Becoming a Much Bigger Analytical Challenge</h4>PFAS analysis has rapidly evolved from a specialized environmental testing problem into a much broader challenge involving drinking water, food, packaging, laboratory contamination, international regulation, data analysis, and even destruction technologies. In an interview with Michelle Taylor, Editor-in-Chief of Labcompare, the discussion explored what laboratories are learning from the latest PFAS research—and why the analytical demands are likely to continue growing.Taylor leads editorial content for Labcompare, an online resource covering analytical laboratory instrumentation, products, and scientific developments. Among the projects she considers particularly important are two long-form documentaries produced by Labcompare examining per- and polyfluoroalkyl substances (PFAS), first through drinking water and subsequently through food.The documentaries brought together subject-matter experts working across PFAS analysis and exposed some of the practical realities laboratories now face: rapidly changing regulations, extremely low detection limits, complex matrices, contamination risks, and sample volumes that can overwhelm laboratory capacity.<h4>From drinking water to seafood</h4>One of the most memorable findings for Taylor came during production of the second documentary, which focused on PFAS in food.Several experts interviewed for the project told her they had stopped eating seafood, in some cases many years earlier, because of concerns surrounding contamination. For Taylor, the consistency and immediacy of those responses illustrated how closely analytical research can intersect with everyday decisions.Seafood also demonstrates why PFAS testing can become analytically difficult.Fish and other high-lipid samples require effective extraction to release the analytes, followed by rigorous cleanup to remove fats. According to the experts Taylor interviewed, the cleanup step is particularly critical because residual lipids can damage LC columns and create severe matrix interferences.Laboratories are therefore using approaches such as enhanced matrix removal and carbon- or silica-based sorbents to reduce the lipid content of extracts before instrumental analysis. The goal is not simply obtaining sufficient recovery, but producing an extract clean enough to maintain analytical performance and laboratory throughput.<h4>How laboratories are handling the PFAS sample burden</h4>The analytical sensitivity now required for PFAS testing presents another challenge: laboratories may need to measure compounds at parts-per-trillion levels while processing growing numbers of samples.Automation has therefore become increasingly important, particularly during sample preparation, where repetitive manual procedures can otherwise create a major bottleneck.Taylor also described a tiered analytical strategy being used by some laboratories. A less demanding measurement can first be used for screening, while samples generating a positive result are subsequently transferred to a more sensitive platform, such as triple-quadrupole mass spectrometry, for confirmation and quantitation.This type of workflow can help laboratories concentrate their highest-performance instrumentation on the samples that actually require it rather than applying the most intensive analysis to every incoming sample.The broader principle is likely to become increasingly important as PFAS testing expands: laboratories must find ways to increase throughput without sacrificing the sensitivity demanded by regulatory methods.<h4>When the laboratory itself becomes a source of PFAS</h4>At trace concentrations, contamination introduced during sample preparation or measurement can become comparable to the concentration being determined.This makes the materials used throughout the analytical workflow particularly important.Taylor emphasized that PFAS laboratories must maintain continuous awareness of potential contamination from solvents, water, tubing, containers, and other laboratory components. Equipment containing fluoropolymers such as PTFE may be problematic in certain PFAS workflows because background contamination can contribute to false positives or elevated blanks.As detection limits move lower, dedicated PFAS-compatible or fluoropolymer-free laboratory equipment becomes increasingly valuable.Taylor described manufacturers offering clearly identified PFAS-free configurations as an important response to this problem. Rather than forcing laboratories to investigate the material composition of each component individually, dedicated configurations can simplify method implementation and reduce uncertainty about potential background sources.For laboratories already dealing with demanding workflows and large sample loads, eliminating potential contamination before it occurs can save considerable troubleshooting time.<h4>Food packaging could drive the next major wave of testing</h4>PFAS concerns are not limited to the food itself.The interview also examined food-contact materials, including takeout containers and other packaging from which PFAS may migrate into food. State-level restrictions in the United States are already beginning to affect the materials manufacturers can use.For contract laboratories, this creates the possibility of another significant increase in demand for compliance and migration testing.Taylor’s recommendation is straightforward: laboratories should follow proposed regulations before they become final.Waiting until a new requirement takes effect can leave a laboratory simultaneously trying to acquire instrumentation, establish methods, train staff, and respond to customer demand. Monitoring regulatory agencies, scientific meetings, and industry discussions earlier gives laboratories time to prepare analytical capabilities before the testing requirement becomes urgent.She expects PFAS restrictions in food packaging to continue developing first through a patchwork of individual state regulations. Once a sufficient number of states adopt restrictions, however, the economics may increasingly encourage suppliers to move toward PFAS-free materials regardless of whether every jurisdiction requires them.A national standard could eventually follow that transition.<h4>One sample, two regulatory environments</h4>International food exporters face another complication: PFAS requirements are not necessarily the same between the United States and European Union.Taylor noted that laboratories serving both markets may effectively need to operate under a dual-compliance model.In the interview, she highlighted EU requirements targeting specific PFAS—including PFOS, PFOA, PFNA, and PFHxS—at very low concentrations in certain foods, while the U.S. approach has historically involved a different combination of monitoring programs, evolving compound lists, and import-related requirements.For laboratories supporting international customers, this means more than simply selecting a different reporting limit.Different markets may require different target lists, methods, documentation, auditing, and compliance procedures. Laboratories therefore need analytical platforms capable of ultratrace measurements while also maintaining the operational flexibility to support multiple regulatory frameworks.That additional complexity also carries a practical cost: performing different protocols for different jurisdictions means more staff time, additional workflow management, and potentially greater instrument demand.<h4>Total fluorine screening can help laboratories decide what to analyze next</h4>Targeted LC-MS/MS methods are highly sensitive, but they only measure compounds included in the analytical panel.This creates an important question: what about fluorinated substances that are present but are not included in the targeted method?The interview discussed EPA Method 1621, which uses a broader fluorine-based screening approach. Taylor described this type of measurement as useful for helping laboratories assess the gap between compounds captured by targeted LC-MS/MS methods and the broader amount of organofluorine present in a sample.Such screening can also become part of a tiered workflow.For applications such as food packaging, laboratories could initially use a broader fluorine measurement to determine whether a sample warrants further investigation. Positive or suspicious samples could then move to more selective and sensitive targeted analysis for identification and quantitation.Non-targeted high-resolution mass spectrometry can add another layer by revealing compounds outside conventional target lists.Together, these approaches create a funnel from broad screening toward increasingly detailed characterization rather than attempting the most comprehensive analysis on every sample from the outset.<h4>PFAS analysis is becoming a data problem too</h4>High-resolution mass spectrometry can generate enormous datasets containing signals from large numbers of known and unknown compounds.As a result, Taylor believes the role of the analytical chemist is changing.Strong laboratory skills remain essential, but scientists increasingly need data literacy as well. Understanding complex datasets, working with advanced software, and interacting effectively with artificial intelligence and machine-learning tools are becoming important parts of modern analytical work.Taylor does not see this change primarily as replacing scientific expertise.Instead, she compares it with earlier laboratory automation: repetitive or technically demanding tasks can increasingly be handled by software, allowing scientists to spend more time interpreting results and making decisions.AI may also make sophisticated analytical information more accessible. A less experienced mass spectrometry user could potentially receive explanations of complex data through software capable of presenting results in natural language, reducing dependence on a single specialist being immediately available.There is another potential advantage beyond speed.Machine-learning systems can recognize patterns across large datasets that may be difficult or impossible for an individual scientist to detect manually. As analytical datasets become larger and multidimensional, that pattern-recognition capability could become increasingly valuable.<h4>Finding PFAS is only the first half of the problem</h4>For years, much of the PFAS discussion has focused on answering two questions:<ul><li>Are PFAS present, and how much is there?</li></ul>The next challenge is considerably harder: how do we actually remove or destroy them?Taylor described this as an expanding research field that will increasingly involve analytical laboratories.The strength of the carbon-fluorine bond makes PFAS destruction difficult. Some treatment approaches seek to break this bond and achieve complete defluorination, but incomplete destruction can create another analytical problem.For example, thermal treatment may transform longer-chain PFAS into shorter-chain fluorinated compounds rather than eliminating them completely. Those products may then enter another environmental compartment, including atmospheric emissions.Consequently, laboratories studying PFAS destruction must do more than measure disappearance of the original compound. They also need to determine whether fluorinated transformation products or other byproducts remain.Analytical chemistry therefore has two roles: monitoring PFAS contamination and demonstrating whether remediation technologies truly destroy the substances they are intended to remove.<h4>The PFAS problem is expanding beyond water and food</h4>The first two Labcompare documentaries focused primarily on water and food, two matrices already receiving substantial regulatory and public attention.But Taylor does not expect the story to end there.If Labcompare produces another PFAS documentary, she sees PFAS in air as a likely subject. Discussions with experts during earlier filming repeatedly raised atmospheric contamination, including both direct environmental occurrence and emissions potentially associated with treatment or destruction processes.The progression illustrates how quickly the PFAS field is expanding.Drinking water regulation accelerated analytical development. Food testing introduced more difficult matrices and new exposure pathways. Packaging is creating another compliance challenge. Environmental remediation raises questions about destruction products. Atmospheric monitoring could become another significant frontier.For laboratories already working with chromatography and mass spectrometry, Taylor’s message is essentially to be prepared—even organizations that do not currently consider themselves “PFAS laboratories” may eventually become involved.<h4>An analytical field that is still changing rapidly</h4>Perhaps the strongest theme running through the interview is that PFAS analysis has no fixed endpoint yet.Methods continue to evolve. Regulations change. Target compound lists expand. Instrument sensitivity improves. Laboratories discover new sources of background contamination, while researchers identify additional exposure pathways and investigate new destruction technologies.Taylor compares the situation to earlier periods of rapid analytical development, such as the evolution of forensic DNA analysis: each technological advance reveals more information, which in turn creates new questions and new analytical requirements.That makes preparation particularly important.Laboratories cannot predict every future regulation, but they can follow proposed requirements, develop flexible workflows, invest in contamination control and data capabilities, and understand how their existing chromatography and mass spectrometry expertise could be applied to emerging PFAS challenges.The analytical problem is no longer simply detecting a group of “forever chemicals.”It is becoming a much larger question of how we identify them, quantify them, prevent contamination during analysis, understand their movement through food and the environment, comply with evolving regulations, and ultimately prove that they have actually been destroyed.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

PFAS in Water, Food & Packaging: Michelle Taylor on the "Forever Chemicals" Documentary Series

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Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Thermo Scientific Dionex IonPac AS9-SC IC Columns

Separate inorganic anions and oxyhalides in simple matrices using an isocratic carbonate/bicarbonate eluent with the Thermo Scientific™ Dionex™ IonPac™ AS9-SC Carbonate Eluent Anion-Exchange Column.

Separate inorganic anions and oxyhalides in simple matrices using an isocratic carbonate/bicarbonate eluent with the Thermo Scientific™ Dionex™ IonPac™ AS9-SC Carbonate Eluent Anion-Exchange Column. The Dionex IonPac AS9-SC column is specified in US EPA Method 300.0 (B), and meets or exceeds the performance requirements of this method. However, the advanced, high-capacity Dionex IonPac AS23 Carbonate Eluent Anion-Exchange column is recommended for determination of oxyhalides and inorganic anions, such as trace bromate, in ozonated drinking water.<h5>Fast Separation of Inorganic Anion and Oxyhalides in Simple Matrices</h5><ul><li>Compliance monitoring of common anions and oxyhalides in drinking water as specified in U.S. EPA Methods 300.0 (B)</li><li>Simple, isocratic separation of inorganic anions in less than 10 minutes in drinking water</li><li>Fast isocratic separation of inorganic anions and oxyhalides in ozonated drinking water matrices</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5>Formats Available for Application Flexibility</h5><ul><li>4x250mm analytical columns</li><li>4x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li></ul><h4>Specifications</h4><ul><li>Column Capacity: 30 to 35 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Separation of Oxyhalides and Inorganic Anions, Anion Exchange</li><li>Ion Exchange Group: Alkyl Quaternary Ammonium</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 2 to 11, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS9-SC</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS23-4μm IC Columns

Analyze trace bromate and other oxyhalides in drinking water, ground water, wastewater, and other diverse matrices using the Thermo Scientific™ Dionex™ IonPac™ AS23-4μm columns. 

Analyze trace bromate and other oxyhalides in drinking water, ground water, wastewater, and other diverse matrices using the Thermo Scientific™ Dionex™ IonPac™ AS23-4μm columns. The high capacity and selectivity of this column facilitates the determination of trace bromate at low-μg/L levels in the presence of high amounts of chloride, sulfate, and carbonate. Compared to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2058">Dionex IonPac AS23 column</a>, the new Dionex IonPac AS23-4μm columns use smaller resin particles for more efficient separations resulting in more accurate peak integration and more reliable results.<h5>Designed Specifically for Trace Bromate Analysis in Drinking Water</h5><ul><li>Use the Dionex IonPac AS23-4μm for diverse matrices including drinking water, ground water, and waste water.</li><li>High capacity allows routine drinking water analysis without sample pretreatment or preconcentration.</li><li>Improved efficiencies and resolution compared to the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2058">Dionex IonPac AS23 column</a>.</li><li>Easily transfer applications from the Dionex IonPac AS23 column to the AS23-4μm column due to the similar selectivity.</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, and facilitate effective column clean-up.</li></ul><h5>Use With a High-Pressure IC System</h5>Higher resolution is achieved through the use of smaller resin particles, which produce a column backpressure over 3000psi at the standard flow rates. A high-pressure IC system, such as the Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ or the Thermo Scientific™ Dionex™ Integrion™ HPIC™ system is required to operate this column under standard conditions and take advantage of elevated flow rates and faster run times.<h5>Multiple Formats Available</h5><ul><li>4x250mm and 2x250mm analytical columns</li><li>4x50mm and 2x50mm guard columns</li></ul>Note: Use the Dionex AS23 Eluent Concentrate for simple, accurate eluent preparation.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 320 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 320 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS23-4μm</li><li>Format: Standard Bore</li><li>Packing material: Polyvinylbenzyl Ammonium Polymer/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac AS22 Fast IC Columns

Thermo Scientific™ Dionex™ IonPac™ AS22-Fast column combines the selectivity of the Dionex IonPac AS22 column with super-fast separation times. 

Designed specifically for compliance monitoring of inorganic anions in accordance with U.S. EPA Methods 300.0 (A), the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast column combines the selectivity of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2057">Dionex IonPac AS22 column</a> with super-fast separation times. With the Dionex IonPac AS22-Fast column, you can quickly and simply separate common inorganic anions from a variety of sample matrices including drinking water, wastewater, process streams, and scrubber solutions.<h5>Super Fast Analysis of Inorganic Anions and Low Molecular Weight Organic Acids in Diverse Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Super-fast isocratic separation of common inorganic anions in less than 5 min in diverse matrices such as drinking water, surface water, groundwater, and wastewater</li><li>Sufficient capacity to maintain resolution even in a short column format, which helps laboratories achieve higher productivity and increased throughput</li><li>Excellent resolution of the carbonate peak away from the common inorganic anions</li><li>Faster alternative, using carbonate/bicarbonate eluents, for Dionex IonPac AS4A-SC, AS12A, AS14, AS14A and AS22 inorganic anion applications.</li><li>Solvent compatibility permits easy column cleanup after the analysis of samples with hydrophobic components.</li></ul><h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x150mm, 2x150mm analytical columns</li><li>4x30mm, 2x30mm guard columns</li><li>Shorter 150mm columns produce faster runs of relatively clean matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul>Note: For simple, accurate eluent preparation, use the Dionex IonPac AS22 Eluent Concentrate.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 126 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 126 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 3000 psi (207 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS22-Fast</li><li>Format: Standard Bore</li><li>Packing Material: Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS22 Fast-4μm IC Columns

Attain the optimal combination of chromatographic speed and resolution using the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast-4μm column.

Attain the optimal combination of chromatographic speed and resolution using the Thermo Scientific™ Dionex™ IonPac™ AS22-Fast-4μm column. Designed specifically for compliance monitoring of inorganic anions in accordance with U.S. EPA Method 300.0 (A), this moderate capacity column combines the selectivity of the Dionex IonPac AS22-Fast column with fast high resolution separations. Compared to the Dionex IonPac AS22-Fast column, the new Dionex IonPac AS22-Fast-4μm column uses smaller resin particles for more efficient separations resulting in faster run times, more accurate peak integration and more reliable results.<h5>Fast separation of common inorganic anions with excellent resolution</h5><ul><li>Obtain the highest peak efficiency, through the use of smaller resin particles, of common inorganic anions in diverse sample matrices</li><li>Attain fast isocratic separation of the common inorganic anions in less than 5 min</li><li>Perform compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Achieve excellent separation of inorganic anions and low-molecular weight acids in diverse sample matrices</li><li>Obtain high peak efficiency and increased peak resolution for more consistent integration and more reliable results</li><li>Transfer application easily--this 4μm column has the the same selectivity as the Dionex IonPac AS22-Fast column</li><li>Achieve excellent resolution of the carbonate peak away from the common inorganic anions</li><li>Reduce run time without loss of resolution compared to the Dionex IonPac AS22-Fast column</li><li>Faster alternative, using carbonate/bicarbonate eluents, for Dionex IonPac AS4A-SC, AS12A, AS14, AS14A and AS22 inorganic anion applications</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5>Use with a high-pressure IC system</h5>Higher resolution is achieved through the use of smaller resin particles, which can produce a column backpressure over 3000 psi. When operating the Dionex IonPac AS22-Fast-4μm column, a high-pressure IC system, such as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/410">Thermo Scientific™ Dionex™ ICS-6000 HPIC</a> system is required.<h5>Use the format that fits your lab</h5><ul><li>4x150mm, 2x150mm analytical columns</li><li>4x30mm, 2x30mm guard columns</li><li>Shorter 150mm columns facilitate faster runs while the smaller particle size maintains a higher resolution separation</li></ul>Note: For simple, accurate eluent preparation, use the Dionex IonPac AS22 Eluent Concentrate or the Dionex Eluent Generator (Dionex EGC 500 K2CO3 cartridge with Dionex EPM 500 pH modifier).<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 126 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 126 μeq</li><li>Column Chemistry: Carbonate/Bicarbonate</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: Super Macroporous Resin</li><li>Format: Standard Bore</li><li>Packing Material: Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS19-4μm IC Columns

Achieve high resolution separations of trace oxyhalides and inorganic anions in drinking water using the Thermo Scientific™ Dionex™ IonPac™ AS19-4μm hydroxide-selective anion-exchange column.

Achieve high resolution separations of trace oxyhalides and inorganic anions in drinking water using the Thermo Scientific™ Dionex™ IonPac™ AS19-4μm hydroxide-selective anion-exchange column. Its high resolution, high capacity and selectivity allow the determination of bromate in drinking water at the low-μg/L level. Compared to the previous <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2055">Dionex IonPac AS19 column</a>, this anion-exchange column uses smaller resin particles for more efficient separations resulting in more accurate peak integration and more reliable results.<h5>Easy Method Transfer</h5>With similar selectivity and increased peak efficiencies, you can easily transfer applications from the Dionex IonPac AS19 column to the Dionex IonPac AS19-4μm column.<h5>Significantly Reduce Eluent Usage</h5>The Dionex IonPac AS19-4μm Capillary Column is packed with the same material as the equivalent standard bore version (providing the same performance as a 4mm column), but requires only 1/100th the eluent flow rate. The capillary format provides the advantage of significantly reduced eluent consumption, which helps reduce operating costs.<h5>Dionex IonPac AS19-4μm Capillary Column Features</h5><ul><li>Choose from three formats: 4×250mm, 2×250mm and 0.4×250mm</li><li>Recommended hydroxide-selective column for trace bromate in drinking water matrices</li><li>Meets or exceeds performance requirements of US EPA Method 300.0 and US EPA Method 300.1</li><li>High capacity: 240μeq per column (4×250mm)</li><li>Column selectivity is optimized for 30 °C operating temperature</li><li>Compatible with organic solvents</li></ul>These capillary columns require high pressure Thermo Scientific™ Dionex™ ICS-5000+ or Dionex ICS-4000 HPIC™ system to run at standard flow rates.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 240 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 240 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 5000 psi (345 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS19-4 μm</li><li>Format: Standard Bore</li><li>Packing Material: Polymeric</li></ul>

Thermo Scientific Dionex IonPac AS18-Fast IC Columns

Use these shorter 150mm Thermo Scientific™ Dionex™ IonPac™ AS18-Fast columns for fast runs when monitoring inorganic anions in drinking water and wastewater samples

Use these shorter 150mm Thermo Scientific™ Dionex™ IonPac™ AS18-Fast columns for fast runs when monitoring inorganic anions in drinking water and wastewater samples for compliance with U.S. EPA Methods 300.0 (A) and 300.1. Dionex IonPac AS18 columns are high capacity hydroxide-selective anion-exchange columns. Having the same selectivity as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2054">Dionex IonPac AS18 column</a>, the shorter format significantly reduces run times of common inorganic anions and low molecular weight organic acids in diverse sample matrices including drinking water, wastewater, leachates, foods, beverages, and pharmaceutical preparations.<h5>Analysis of Common Inorganic Anions and Low-Molecular Weight Organic Acids in Diverse Matrices</h5><ul><li>Compliance monitoring of common anions in drinking water as specified in U.S. EPA Method 300.0 (A)</li><li>Determination of low levels of inorganic anions in complex matrices using large-loop injections</li><li>Superior retention and quantification of fluoride, acetate, and formate</li><li>Fast separation of the common inorganic anions in 5 min in simple matrices using 150mm column</li><li>High efficiency, fast analysis use the 150mm column for increased sample throughput</li><li>Compatible with organic solvents to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5>Recommended for Inorganic Anions in Diverse Sample Matrices</h5><ul><li>Source water and drinking water, municipal and industrial wastewater</li><li>Industrial cooling water and waste water, acid rain</li><li>Foods and beverages, anionic counterions in pharmaceutical preparations</li></ul><h5>Multiple Formats for Application Flexibility</h5>The shorter 150mm Dionex IonPac AS18-Fast columns produce faster runs of relatively clean matrices compared to the longer 250mm columns and are available in three formats with guard columns:<ul><li>4x150mm standard bore AS18-Fast columns with 4x30mm guard columns</li><li>2x150mm microbore AS18-Fast columns with 2x30mm guard columns</li><li>0.4x150mm capillary AS18-Fast columns with 0.4x35mm guard columns</li></ul><h5>Capillary Columns Reduce Operating Costs from Lower Eluent Requirements</h5>Capillary columns provide significantly reduced operating and waste disposal costs through eluent conservation. Packed with the same material, the Dionex IonPac AS18-Fast capillary columns provide the same performance as the standard bore and microbore counterparts. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system. Capillary columns are used with the Thermo Scientific™ Dionex™ ICS-4000 and ICS-5000+ Capillary systems.<h5>Need Higher Resolution or Faster Separations?</h5>If you need higher resolution separations of more complex sample matrices, refer to the longer 250mm Dionex™ IonPac™ AS18 Hydroxide-Selective Anion-Exchange column For fastest, highest resolution separations of relatively cleaner sample matrices, refer to the small particle Dionex™ IonPac™ AS18-4µm Hydroxide-Selective Anion-Exchange column. Use of 4µm columns requires a high-pressure IC system.<h4>Specifications</h4><ul><li>Anion Exchange Capacity: 171 μeq</li><li>Crosslinking: 55% DVB</li><li>Column Capacity: 171 μeq</li><li>Column Chemistry: Hydroxide</li><li>For Use With (Application): Anion Exchange</li><li>Ion Exchange Group: Alkanol Quaternary Ammonium Ion</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac AS18-Fast</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS10 IC Columns

Choose Thermo Scientific Dionex IonPac CS10 Cation-Exchange Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. 

Choose Thermo Scientific™ Dionex™ IonPac™ CS10 Cation-Exchange Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. Well suited to determine common inorganic cations and aliphatic and aromatic amines in diverse sample matrices, including environmental waters, power plant waters treated with ammonium, morpholine, or ethanolamine; chemical additives; chemical process solutions; scrubber solutions; plating baths; and industrial solvents.<h5>Recommended Cation-Exchange Columns by Use</h5>Since the introduction of the Dionex IonPac CS10 column, Dionex has introduced several new cation-exchange columns with advanced features. These modern columns and their recommended uses are listed below.<ul><li>The Dionex IonPac CS11 column has selectivity similar to the Dionex IonPac CS10 column, with improved sensitivity and lower eluent consumption due to its smaller 2 mm i.d. format.</li><li>The Dionex IonPac CS12A column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices.</li><li>The Dionex IonPac CS17 column is recommended for hydrophobic and polyvalent amines.</li><li>The Dionex IonPac CS19 and CS19-4μm columns are recommended for polar amines including alkanolamines and methylamines and also moderately hydrophobic amines and polyvalent amines.</li><li>Compatible with organic solvents, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5>Formats Available for Application Flexibility</h5><ul><li>4x250mm analytical column</li><li>4x50mm guard column</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li></ul><h4>Specifications</h4><ul><li>Column Capacity: 80 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac CS10</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS11 IC Columns

Choose Thermo Scientific Dionex IonPac CS11 low-capacity, sulfonate-functionalized, cation-exchange column for isocratic separation of inorganic cations using HCl with DAP eluents.

Choose Thermo Scientific™ Dionex™ IonPac™CS11 Analytical and Guard Columns for isocratic separation of inorganic cations using hydrochloric acid (HCl) with diaminopropionic (DAP) acid eluents. This column has selectivity similar to the IonPac CS10 column, with improved sensitivity and lower eluent consumption due to its smaller 2mm I.D. format.The Dionex IonPac CS11column can be used to determine common inorganic cations and aliphatic and aromatic amines in diverse sample matrices, however, advances in cation-exchange column technology have produced better column choices for these separations.<h5>Recommended Cation-Exchange Columns by Use</h5>Since the introduction of the Dionex IonPac CS11 column, Dionex has introduced several new cation-exchange columns with advanced features. For example, most modern Dionex IonPac Cation Exchange columns use simple methanesulfonic acid eluents rather than DAP-HCl eluents. These columns and their recommended uses are listed below.<ul><li>The Dionex IonPac CS12A column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices.</li><li>The Dionex IonPac CS17 column is recommended for hydrophobic and polyvalent amines.</li><li>The Dionex IonPac CS19 and CS19-4μm columns are recommended for polar amines including alkanolamines and methylamines and also moderately hydrophobic amines and polyvalent amines.</li><li>Compatible with organic solvents, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup</li></ul><h5>Formats Available for Application Flexibility</h5><ul><li>2x250mm analytical column</li><li>2x50mm guard column</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 5% DVB</li><li>Column Capacity: 35 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: pH 0 to 14, 0 to 100% HPLC Solvents</li><li>Stationary phase: IonPac CS11</li><li>Format: Microbore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS12 IC Columns

Obtain robust, reliable results and fast isocratic separation of common inorganic cations and alkanolamines using the Thermo Scientific Dionex IonPac CS12 Cation-Exchange Column.

Obtain robust, reliable results and fast isocratic separation of common inorganic cations and alkanolamines using the Thermo Scientific™ Dionex™ IonPac™ CS12 Cation-Exchange Column. This is a high-capacity, cation-exchange column designed for the fast, isocratic separation of lithium, sodium, ammonium, potassium, magnesium, and calcium using methanesulfonic or sulfuric acid eluents in diverse sample matrices. However, the newer Thermo Scientific™ Dionex™ IonPac™ CS12A column provides improved performance and is the recommended column for inorganic cation analysis.<h5>Fast Isocratic Separation of Common Inorganic Cations</h5>The Dionex IonPac CS12 Cation-Exchange Column provides fast, isocratic separation of cations in diverse sample matrices, including drinking water, power plant waters, soil extracts, acid digests, chemical additives, chemical process solutions, scrubber solutions, and plating baths. However, the Dionex IonPac CS12A column improves performance for fast analysis of inorganic cations and ammonium in diverse matrices and is the recommend column for these applications. The columns are compatible with organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity, or allow effective column cleanup<h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 2x250mm analytical columns</li><li>4x50mm, 2x50mm guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 2.8 meq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: Acidic Eluents, 0 to 100% HPLC Solvent Compatible, Alcohols Should be Avoided</li><li>Stationary phase: Macroporous Resin</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Thermo Scientific Dionex IonPac CS12A IC Columns

Separate common cations in as little as four minutes using methanesulfonic acid (MSA) or sulfuric acid eluents with Thermo Scientific Dionex IonPac CS12A Cation-Exchange Columns.

Separate common cations in as little as four minutes using methanesulfonic acid (MSA) or sulfuric acid eluents with Thermo Scientific™ Dionex™ IonPac™ CS12A Cation-Exchange Columns. These medium-capacity, carboxylate-functionalized cation-exchange columns are recommended for fast, isocratic separation of lithium, sodium, ammonium, potassium, magnesium, and calcium in diverse sample matrices. The IonPac CS12A column is the recommended replacement for all IonPac CS12 column applications.<h5>Analysis of Common Cations plus Ammonium in Diverse Sample Matrices</h5><ul><li>Superior fast isocratic separation of mono- and divalent cations plus ammonium in diverse, complex matrices</li><li>Isocratic separation of Group I and II cations plus ammonium in 15 minutes in diverse matrices using a 250mm column</li><li>Fast, high resolution, isocratic separation of Group I and II cations plus ammonium in 4 minutes in simple matrices using 150mm column</li><li>Higher-capacity applications use 250mm columns, allowing injection of more concentrated samples without overloading or peak broadening</li><li>High efficiency, fast analysis use the 150mm column for increased sample throughput</li><li>Dionex IonPac CS12A-MS column provides fast elution at the low flow rates required for IC-MS, making it the ideal choice for IC-MS screening</li><li>Compatible with organic solvents, excluding alcohols, to enhance analyte solubility, modify column selectivity or allow effective column cleanup</li></ul>The Dionex IonPac CS12A-8μm and CS12A-5μm Capillary Columns offer the same selectivity as their analytical-scale counterparts with lowering operating costs.<h5>Recommended for Common Cations and Ammonium in Diverse Sample Matrices</h5><ul><li>Source water and drinking water, municipal and industrial wastewater, soil extracts, acid digests</li><li>Industrial cooling water, scrubber solutions; plating baths; and industrial solvents</li><li>Power plant waters treated with ammonium or morpholine; chemical additives; chemical process solutions</li></ul><h5>Reduce Operating Costs With Lower Eluent Requirements</h5>The Dionex IonPac CS12A capillary columns provide the same performance as the standard bore and microbore Dionex IonPac CS12A columns because they are packed with the same material. Operating costs are reduced because the capillary system operates at only 1% of the eluent flow rate of the standard bore system, requiring less eluent and producing less waste.<h5>Multiple Formats Available for Application Flexibility</h5><ul><li>4x250mm, 2x250mm, 3x150mm or 2x100mm analytical columns</li><li>4x50mm or 2x50mm, 3x30mm guard columns</li><li>0.4x250mm, 0.4x150mm capillary columns</li><li>0.4x50mm or 0.4x35mm capillary guard columns</li><li>Longer 250mm columns facilitate higher resolution separations of more complex sample matrices</li><li>Shorter 150mm and 100mm columns produce faster runs of relatively clean matrices</li><li>Smaller i.d. columns provide higher mass sensitivity, eluent and reagent conservation and lower operating costs</li></ul><h4>Specifications</h4><ul><li>Crosslinking: 55% DVB</li><li>Column Capacity: 2800 μeq</li><li>For Use With (Application): Cation Exchange</li><li>Max. Pressure: 4000 psi (275 bar)</li><li>Solvent Compatibility: Acidic Eluents, 0 to 100% Acetonitrile, Alcohols Should be Avoided</li><li>Stationary phase: IonPac CS12A-8μm</li><li>Format: Standard Bore</li><li>Packing Material: Ethylvinylbenzene/Divinylbenzene</li></ul>

Products from category Ion Chromatography Columns (IC) - page 2

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