Commercial and public spectral libraries provide broad coverage for LC-MS/MS identification, but they cannot contain every compound that matters to a specific laboratory. Proprietary products, metabolites, intermediates, impurities, degradation products, biomarkers, and internally characterized compounds may be highly relevant even if they are absent from standard reference collections. NIST26 allows laboratories to build their own MS/MS user libraries and integrate them directly into routine search workflows, creating a focused resource tailored to their analytical needs.<h4>Why Create a User MS/MS Library?</h4>User libraries are usually much smaller than commercial or public spectral databases, but their value is not determined by size alone.A laboratory-specific library may contain exactly the compounds most important for a particular application. These can include:<ul><li>proprietary products,</li><li>known metabolites,</li><li>synthesis intermediates,</li><li>impurities,</li><li>degradation products,</li><li>biomarkers,</li><li>compounds associated with specific industrial or environmental samples.</li></ul>Such libraries can therefore provide highly relevant identifications in pharmaceutical development, industrial R&amp;D, medical laboratories, environmental analysis, and other specialized fields. A relatively small collection of carefully characterized compounds may be more useful for a particular laboratory than a much larger general-purpose database.&nbsp;<h4>What Information Can Be Stored with Each Spectrum?</h4>Creating a useful library entry involves more than importing an MS/MS spectrum.A complete record can combine several types of information, including the experimental spectrum, chemical structure, instrumental parameters, ionization information, sample history, and additional user-defined metadata.Spectra can be transferred from vendor software into NIST Library Search, or they can be sent from the Chromatogram tab directly to the Library Search environment in NIST26. Chemical structures can be imported through the Windows clipboard from a molecular drawing program, while standard experimental parameters and sample-history information can be prepared separately and added to the entry.&nbsp;The ability to keep analytical metadata together with the spectrum is particularly important for internally generated libraries because it preserves the context in which the reference spectrum was acquired.<h4>Using Tags to Organize LC-MS/MS Metadata</h4>NIST26 supports a range of structured tags for LC-MS/MS spectra.These can describe parameters such as:<ul><li>spectrum type,</li><li>compound type,</li><li>ion name,</li><li>precursor type,</li><li>precursor m/z,</li><li>collision energy,</li><li>instrument type,</li><li>sample identifier,</li><li>ionization mode,</li><li>ion polarity,</li><li>collision gas,</li><li>pressure,</li><li>mass range,</li><li>maximum intensity,</li><li>cone voltage,</li><li>charge,</li><li>molecular weight,</li><li>known impurities,</li><li>related CAS numbers,</li><li>peptide sequence and peptide modifications.</li></ul>This provides a convenient way to attach searchable and standardized experimental information to spectra rather than leaving all metadata in an unstructured comment field.&nbsp;Tags can be entered individually through the Additional Info section in the Librarian interface, but when many spectra are being added, a grouped approach can be considerably faster.&nbsp;<h4>Adding Groups of Tags Efficiently</h4>For repetitive workflows, metadata can be prepared in advance and pasted into NIST26 as a group.The presentation recommends maintaining frequently used tag sets in a simple text document, then copying them into the synonym field and using Add to List to convert them into structured information.This is especially useful when the vendor software already transfers some parameters automatically. Users can then add only the missing information, such as ion adduct or polarity, rather than duplicating metadata already imported with the spectrum.&nbsp;Care is required because entering information that is already present may create duplicate metadata.This workflow can substantially accelerate library creation when many spectra share the same instrument configuration or acquisition parameters.<h4>Preserving Sample History</h4>A spectral match is more useful when the origin of the reference spectrum is known.NIST26 therefore allows detailed sample information to be stored in the comment field. For batches of related samples, the text can be prepared in Notepad or another editor and pasted into multiple records.Examples of useful information include sampling location, sampling date and time, analyst name, organization, internal sample identifier, project information, or other relevant context.&nbsp;For environmental, clinical, pharmaceutical, and industrial laboratories, this information can become an important part of data traceability.<h4>Adding Molecular Structures</h4>A user library becomes considerably more useful when spectra are linked to molecular structures.Structures can be created from scratch in a chemical drawing program. Alternatively, a similar structure can be located in NIST Search and sent to the default structure editor, where it can be modified as needed.Once completed, the structure can be copied to the Windows clipboard and inserted into the NIST Librarian spectrum-information window. NIST26 can then calculate the molecular formula and molecular weight from the imported structure.&nbsp;This linkage between spectrum and structure supports more informative library displays and structure-based searching.<h4>Creating Custom User-Defined Tags</h4>In addition to the standard LC-MS/MS tags, laboratories can define their own metadata fields.Examples shown include identifiers such as:<ul><li>chemist,</li><li>laboratory notebook number,</li><li>analyst.</li></ul>The information can be prepared in a text editor and added using the appropriate tag syntax. Once configured in the Comment Field Display settings, these values are displayed as separate structured lines rather than remaining embedded in the general comments.&nbsp;This flexibility makes the library more suitable for laboratories with established internal documentation systems or quality-management requirements.NIST can also automatically add information such as the InChIKey and an estimated retention index when appropriate structural information is available.&nbsp;<h4>High-Resolution and Low-Resolution Libraries Should Be Kept Separate</h4>User libraries do not have to contain only high-resolution spectra.Low-resolution MS/MS spectra may also be valuable, including spectra generated by:<ul><li>in-source collision on single-quadrupole instruments,</li><li>triple-quadrupole MS/MS,</li><li>other nominal-mass workflows.</li></ul>The recommendation is to maintain separate high-resolution and low-resolution user libraries, because the appropriate search strategies and handling can differ.&nbsp;Low-resolution spectra can still generate strong library-search results and may be particularly useful when laboratories want to preserve historical data or incorporate spectra from multiple instrument types.<h4>Important Software Considerations When Importing Spectra</h4>The presentation also highlights several practical software issues that users should be aware of.One concerns the Intensity Threshold setting in the Spectrum Import Options window. When an intensity threshold is applied during import from vendor software, high-resolution spectral values may be converted to nominal mass rather than preserving the expected decimal precision.For laboratories building high-resolution user libraries, this is an important detail because accurate-mass information is one of the main advantages of HRMS data.Another issue affects some library-search modes after high-resolution spectra are added to a user library.<h4>HiRes No Precursor and Hybrid Search Limitations</h4>After adding high-resolution spectra, certain HiRes NoPrecursor and Similarity Hybrid MS/MS searches may not function correctly.A workaround involves exporting the affected library using Lib2NIST into MSP ASCII files together with the associated molecular structure files, then importing the data back into NIST library format.&nbsp;The presentation specifically warns against attempting the problematic MS/MS Hybrid Search under these conditions because it may cause the software to crash.An EI Normal search can mimic some of the functionality of HiRes No Precursor and may work effectively when high- and low-resolution libraries are searched together. HiRes NoPrecursor can also operate with presearch disabled, although this can make searching considerably slower.&nbsp;<h4>Display Issues in the Chromatogram Window</h4>Another software behavior concerns how spectral values are displayed in the Chromatogram tab.Values from Spectrum Import Options are reflected in the head-to-head spectral display. If settings are adjusted for low-resolution spectra, the displayed masses may appear truncated.Importantly, this visual behavior does not affect the results in the accurate-mass deconvolution and library-searching table; it affects only the spectral display at the top of the Chromatogram window.&nbsp;Distinguishing display behavior from actual processing results is important to avoid misinterpreting valid search results as corrupted data.<h4>Updating the Library After Adding New Entries</h4>User-library maintenance does not end when a spectrum has been added.Whenever a new entry containing a molecular structure is introduced, the structure index should be updated so that the new compound can be included properly in structure searching.The InChIKey appears to update with the structure, but if duplicate records are not being handled correctly, the InChIKey index may also need to be rebuilt.&nbsp;If a new library folder is added to the NIST26 MSSEARCH directory while the software is already running, users should also update the library list so that the newly added collection becomes available without restarting the entire environment.&nbsp;<h4>Using Lib2NIST to Repair High-Resolution User Libraries</h4>The Lib2NIST utility plays an important role in resolving some high-resolution library-search issues.The workflow involves exporting the problematic high-resolution library to an MSP file together with its molecular structure files and then re-importing the data into NIST library format.The corrected library can then be placed back into the NIST26 MSSEARCH directory. It is advisable to preserve the original library under a different name until the repaired version has been tested successfully.&nbsp;The presentation also recommends closing NIST Search while performing Lib2NIST conversions.<h4>Small Libraries Can Deliver High Analytical Value</h4>The central message is straightforward: a user library does not need to contain hundreds of thousands of compounds to be useful.A carefully curated collection of spectra from compounds that repeatedly appear in a laboratory's own samples can dramatically improve identification relevance. This is especially valuable for compounds that are proprietary, newly synthesized, application-specific, or otherwise poorly represented in public and commercial databases.By combining MS/MS spectra with structures, acquisition metadata, sample history, tags, and internally defined information, NIST26 can become more than a search engine for commercial databases. It can serve as a laboratory-specific knowledge base built around compounds that genuinely matter to the user's work.For specialized LC-MS/MS workflows, that may be one of the most valuable ways to extend the capabilities of spectral library searching.

Creating MS/MS User Libraries in NIST26

Wiley announces the expansion of its spectral libraries across IR and Raman, adding empirical and computed reference data spanning forensics, pigments and dyes, mineralogy, materials, polymers, and pharmaceuticals. This release adds over a thousand new empirical reference spectra, plus more than 429,000 new SmartSpectra records, across dozens of updated and new databases. This brings the combined collections to over 1.4 million IR spectra and 230,000 Raman spectra.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Wiley_continues_to_expand_its_IR_Raman_and_Smart_Spectra_spectral_libraries_806b34cdc1.jpg" alt="Wiley: Wiley continues to expand its IR, Raman, and SmartSpectra spectral libraries" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Wiley_continues_to_expand_its_IR_Raman_and_Smart_Spectra_spectral_libraries_806b34cdc1.jpg 245w," sizes="100vw" width="1600" height="838">“Scientific discoveries and business decisions depend on trustworthy analytical results,” said Graeme Whitley, senior director, data science solutions at Wiley. “The value of a spectral library expansion is not simply that it adds more records. It gives analysts more relevant reference candidates when they encounter unfamiliar materials, whether they are verifying a polymer, investigating a pharmaceutical sample, examining a mineral, or screening a forensic specimen.”<h4>Highlights include:</h4><ul><li>Forensics: A new Raman forensics database adds reference spectra for colorant and dye identification on textiles, drawn from real fiber-evidence research, useful for investigators working on dye and textile analysis.</li><li>Pigments and dyes: New Raman and IR data significantly broadens pigment and dye coverage, including historic artists' pigments, supporting art conservation and cultural-heritage authentication work.</li><li>Minerals: New Raman and IR data extends coverage to minerals from different localities and Martian mineral analogs. This release includes new Raman additions from our ongoing collaboration with the American Museum of Natural History, now cross-referenced with DANA Classification Numbers and Mindat IDs, giving mineralogists and gemologists an easier way to identify entries against established references.</li><li>Materials and semiconductors: New Raman and IR data covers crystal growth relevant to battery materials, rare-earth-doped magnetic crystals, and flexible and 2D semiconductor materials, useful for researchers in battery, magnetic materials, and electronics work.</li><li>Polymers: New Raman and IR data spans 3D-printed, MOF-integrated microlattices, environmental plastic aging and recycled PET materials, and food packaging plastics. New Raman reference spectra also cover more than two dozen synthetic polymer types for identifying microplastics in environmental samples.</li><li>Clinical and pharma: New Raman and IR data covers antibiotic classes, including beta-lactams, and the WHO's essential antibiotic list, plus bone mineralization studies in clinical models. A new IR dataset also adds spectra for common over-the-counter medications, including aspirin, ibuprofen, and paracetamol, helping quality control teams confirm formulations faster.</li><li>SmartSpectra: Our SmartSpectra IR, Raman, and vapor-phase IR collections continue to grow, adding 243,000+ IR, 67,000+ Raman, and 119,000+ vapor-phase IR computed reference spectra to support broad, high-throughput identification.</li></ul><blockquote><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/spectral-databases/">Learn more about Wiley Spectral Databases</a><a target="_blank" rel="noopener noreferrer" href="https://sciencesolutions.wiley.com/how-to-update-knowitall-databases/">Existing subscribers can find guidance on updating their databases here</a></blockquote><h4>Wiley Spectral Databases</h4>Wiley's spectral databases are consistently evolving to meet today's research demands, covering multiple spectral techniques across a wide range of applications including polymers, materials, environmental, forensics, toxicology, pharmaceutical, biotech, automotive, aerospace, food, cosmetics, and more. Built on rigorous quality protocols, Wiley delivers industry-leading spectral data and intelligent tools to accelerate analysis and deliver deeper insights — making it the authoritative, trusted source that analytical labs worldwide rely on.&nbsp;

Wiley continues to expand its IR, Raman, and SmartSpectra spectral libraries

Per- and polyfluoroalkyl substances (PFAS)&nbsp;analysis is no longer&nbsp;defined by&nbsp;a fixed list of known compounds.As regulatory frameworks evolve and scientific understanding deepens, laboratories are being asked to go beyond routine testing. In addition to quantifying known PFAS, they must also investigate unknown, unexpected, and emerging compounds that fall outside predefined target lists.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_509ce49fc2.webp" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_509ce49fc2.webp 245w," sizes="100vw" width="1024" height="526">This shift introduces a fundamental analytical challenge.Targeted quantitation provides robust and validated concentration data for known PFAS. However, by design, it only answers questions about compounds already included in the method. In contrast, non-targeted analysis,&nbsp;using high-resolution accurate-mass&nbsp;(HRAM)&nbsp;data,&nbsp;enables scientists to explore the broader chemical landscape, revealing&nbsp;additional&nbsp;PFAS&nbsp;that were not included in a targeted quantitation method.For PFAS, where thousands of structurally related compounds and transformation products may be present, neither approach&nbsp;alone provides a complete picture.The&nbsp;real challenge&nbsp;lies in connecting these workflows. Discovery findings must be translated into actionable results that can be reviewed, followed up, and reported within a controlled analytical framework.In a previous&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7167">blog post</a>, we introduced how <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759">Thermo Scientific Compound Discoverer software </a>and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/76">Thermo Scientific Chromeleon Chromatography Data System&nbsp;(CDS)&nbsp;</a>connect discovery and routine workflows.&nbsp;Here, we explore what that connection looks like in practice using PFAS analysis as an example.<h3>Why PFAS&nbsp;requires&nbsp;more than one analytical question</h3>PFAS&nbsp;represent a&nbsp;large&nbsp;and diverse class of compounds,&nbsp;with&nbsp;some&nbsp;estimates exceeding&nbsp;40,000 individual substances. Regulatory methods typically focus on a limited subset, yet environmental and biological samples often&nbsp;contain&nbsp;many more&nbsp;PFAS, including precursors and transformation products.This creates two&nbsp;essential and&nbsp;complementary analytical questions:How much of these known PFAS are present?andWhat other PFAS-related compounds might be present?A complete workflow needs to support both&nbsp;questions.<h3>Starting with targeted quantitation</h3>For known PFAS, targeted quantitation&nbsp;remains&nbsp;the&nbsp;backbone of routine analysis.Chromeleon CDS provides&nbsp;a&nbsp;controlled environment for&nbsp;data acquisition, processing, calibration, and reporting. In a PFAS workflow,&nbsp;this supports routine quantitation of predefined targets using laboratory-specific method and review criteria.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_2_7ff8eda8fe.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 1. Targeted quantitation of known PFAS in Chromeleon CDS.&nbsp;This example is&nbsp;from the analysis of PFAS using a&nbsp;Thermo Scientific&nbsp;Orbitrap Exploris&nbsp;240. Here&nbsp;we are showing&nbsp;the&nbsp;calibration curve (right) and extracted&nbsp;ion chromatogram&nbsp;(left)&nbsp;of 7:3 FTCA&nbsp;at 6 ng/L.&nbsp;The bottom&nbsp;half&nbsp;shows the processing method that&nbsp;contains&nbsp;many target PFAS and&nbsp;isotopically-labelled&nbsp;internal standards." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_2_7ff8eda8fe.jpg 208w," sizes="100vw" width="794" height="596">This targeted workflow is essential, but it is only part of the story. A sample may contain PFAS-related compounds not included in the original method.<h3>Looking beyond known PFAS</h3>Once HRAM data have been acquired, the same dataset can be explored beyond the target list using Compound Discoverer software. This enables comprehensive analysis of complex datasets, including:<ul><li>Detection and alignment of unknown features</li><li>Statistical comparison across samples and blanks</li><li>Spectral library searching and database annotation</li><li>Evaluation of isotope patterns, fragmentation, and homologous series</li></ul>For PFAS, this is particularly valuable. The software can leverage characteristic properties such as negative mass defect, CF₂-based homologous series, and diagnostic fragment ions to prioritize PFAS-related candidates and assign confidence to putative identifications.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_3_e523e1cdc9.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 2. Discovery of additional PFAS-related components in Compound Discoverer software. Here we show an example of using PFAS fragment libraries, one of many PFAS-specific resources available within Compound Discoverer software, to annotate fragments within acquired MS2 spectra of two unknown compounds and then identify them as PFAS that were outside the targeted quantitation method." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_3_e523e1cdc9.jpg 233w," sizes="100vw" width="1520" height="1016">The goal of discovery is not simply to generate more data. It is to reduce complexity and identify the most relevant candidates for further investigation with a defined level of confidence.<h3>From discovery to follow-up</h3>One of the most important questions in non-targeted analysis is what happens after candidate identification.Discovery workflows can identify interesting candidates, but those candidates need to move into a practical follow-up process. Scientists may want to monitor them across additional samples, estimate relative or semi-quantitative abundance, trend their presence over time, or include them in a reviewable report.This is where the connection between Compound Discoverer software and Chromeleon CDS becomes especially valuable.After PFAS candidates have been prioritized in Compound Discoverer software, selected components can be transferred back into Chromeleon CDS and incorporated into the Chromeleon processing methods for follow-up analysis. This allows scientists to evaluate these compounds within the same controlled environment used for targeted quantitation.For PFAS analysis, this may support semi-quantitative follow-up for compounds where authentic standards are not yet available. While fully quantitative results require appropriate standards and validated methods, semi-quantitative workflows can provide useful estimates or relative comparisons to help prioritize further investigation.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_4_8ee8ebc2df.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow: Figure 3. Prioritized PFAS candidates brought back into Chromeleon CDS for follow-up. Prioritized PFAS candidates from Compound Discoverer software can be brought back into Chromeleon CDS for follow-up review, semi-quantitative evaluation, and controlled reporting." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_the_Target_List_Connecting_Quantitation_and_Discovery_in_a_Single_Workflow_4_8ee8ebc2df.jpg 245w," sizes="100vw" width="1512" height="751">This is the key workflow advantage: discovery does not stop at identification. It can feed directly into a practical analytical process.<h3>Why this matters</h3>PFAS analysis increasingly requires laboratories to balance routine testing with exploratory investigation.A connected workflow between Chromeleon CDS and Compound Discoverer software supports this by:<ul><li>Combining targeted quantitation and non-targeted discovery to characterize samples more completely</li><li>Reducing manual data transfer and workflow fragmentation</li><li>Enabling discovery results to be reviewed and reported within a controlled CDS environment</li><li>Supporting investigation of emerging PFAS investigations without immediate method redevelopment</li><li>Bridging research-driven insights with routine analytical workflows</li></ul>This reflects a broader shift in analytical science, where the value lies not only in generating data, but in connecting workflows and turning data into actionable information.<h3>Moving PFAS analysis forward</h3>PFAS analysis is evolving from a fixed target list toward a more comprehensive understanding of complex chemical mixtures.Laboratories must quantify known compounds while remaining prepared to identify and evaluate what lies beyond them.By connecting Compound Discoverer software with Chromeleon CDS, laboratories can move seamlessly from targeted quantitation to discovery and into structured follow-up. The result is a more complete view of PFAS contamination and a more efficient path from data to insight.<h3>Learn more</h3>Explore how <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759">Compound Discoverer software</a> and<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/76"> Chromeleon CDS </a>can help connect targeted quantitation and non-targeted discovery workflows for <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/environmental/environmental-contaminant-analysis/emerging-contaminants/pfas-testing.html">PFAS analysis</a>.<blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PFAS #Chromeleon #CompoundDiscoverer #Environmental</blockquote>

PFAS Analysis Beyond the Target List: Connecting Quantitation and Discovery in a Single Workflow

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Thermo Scientific Element 2 HR-ICP-MS

Perform accurate and reliable quantitative multi-element analyses at trace level, with the highest sensitivity and without complicated sample preparation with the Thermo Scientific™ Element™ 2 HR-ICP-MS.

Clean up your spectra. Make your analysis easy. High-Resolution ICP-MS is made for the most flexible and reliable analyses, for the best analytical results. Perform accurate and reliable quantitative multi-element analyses at trace level, with the highest sensitivity and without complicated sample preparation. The Thermo Scientific™ Element™ 2 and Element XR™ High Resolution ICP-MS systems cover the mg/L to sub pg/L concentration range—making them especially suitable for semiconductor, geological and material science laboratories.The Element 2 and Element XR High-Resolution ICP-MS provide class-leading elimination of interferences for the highest level of confidence. With ultra-sensitive and reliable multi-element analyses at trace-level concentrations, there’s no need for complicated sample preparation and method development.In mass spectrometry, spectral interferences occur when the mass-to-charge ratio (m/z) of interfering ions overlap with analyte ions. These interferences are the primary limitation of ICP-MS. Fortunately, there’s a better way. The high mass resolution potential of a sector-field mass spectrometer can physically distinguish and separate an analyte from interferences by exploiting small differences in mass-to-charge. Therefore, high resolution (HR) ICP-MS can quantify concentrations and determine precise isotope ratios for elements across nearly the entire periodic table, regardless of the sample matrix.<figure class="image"><img style="aspect-ratio:779/639;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Element_2_HR_ICP_MS_3960103a20.jpg" alt="Thermo Scientific™ Element™ 2 HR-ICP-MS: High mass resolution (R = 10,000) takes advantage of slight mass differences to analyze elements in the most challenging sample matrices. As an example, Arsenic (75As) in a chlorine matrix is masked by argon chloride (40Ar35Cl, 38Ar37Cl) without using high resolution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Element_2_HR_ICP_MS_3960103a20.jpg 190w," sizes="100vw" width="779" height="639"></figure>High mass resolution (R = 10,000) takes advantage of slight mass differences to analyze elements in the most challenging sample matrices. Arsenic (75As) in a chlorine matrix is masked by argon chloride (40Ar35Cl, 38Ar37Cl) without using high resolution. Selenium (Se) is another key element that benefits from high resolution in common matrices. Beyond chloride matrices, high resolution is frequently applied to separate oxide, argide and nitride interferents, as well as multiply charged ions.<ul><li>Low resolution analyzes non-interfered isotopes with the highest sensitivity.</li><li>Medium resolution guarantees interference-free analysis for most elements in the majority of matrix types.</li><li>High resolution provides unequivocal separation of analytes and interferences in the most challenging matrices</li></ul>The simplicity of high-resolution ICP-MS allows the most advanced performance, without compromising on straightforward and reliable method development. This makes the Element series the platform of choice in top-level research and metrology institutions, as well as advanced routine analysis laboratories across the globe.<h3>Features and benefits</h3><ul><li>High mass resolution: Accurately measure isotope signals separate from spectral interferences and produce clean elemental spectra while retaining flexibility.</li><li>Straightforward analytical methods: Providing visual confirmation of accurate measurements.</li><li>Interference removal: no use of reactive gases.</li><li>High sensitivity: Get accurate and precise multi-element analysis down to pg·L-1 concentrations for all resolutions. The Element XR HR-ICP-MS increases the linear dynamic range by an additional three orders of magnitude for maximum flexibility.</li><li>Ideal for transient multi-elemental signals, such as laser ablation, HPLC, GC, CE, FFF.</li><li>High-precision isotope ratios.</li><li>An advanced research tool with the reliability and robustness to serve in 24/7 production control.</li></ul><figure class="image"><img style="aspect-ratio:650/542;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Element_2_HR_ICP_MS_2_b2de21a704.jpg" alt="Thermo Scientific™ Element™ 2 HR-ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Element_2_HR_ICP_MS_2_b2de21a704.jpg 187w," sizes="100vw" width="650" height="542"></figure><h3>Element 2 HR-ICP-MS</h3>The workhorse for semiconductor applications.The high performance, double-focusing magnetic sector field Element 2 HR-ICP-MS is optimized for ease-of-use, stability and productivity. Get access to a powerful technique for solving specific problems with excellent sensitivity and signal-to-noise ratio.

Thermo Scientific Element XR HR-ICP-MS

Clean up your spectra. Make your analysis easy. High-Resolution ICP-MS is made for the most flexible and reliable analyses, for the best analytical results. Perform accurate and reliable quantitative multi-element analyses at trace level, with the highest sensitivity and without complicated sample preparation. The Thermo Scientific™ Element™ 2 and Element XR™ High Resolution ICP-MS systems cover the mg/L to sub pg/L concentration range—making them especially suitable for semiconductor, geological and material science laboratories.The Element 2 and Element XR High-Resolution ICP-MS provide class-leading elimination of interferences for the highest level of confidence. With ultra-sensitive and reliable multi-element analyses at trace-level concentrations, there’s no need for complicated sample preparation and method development.In mass spectrometry, spectral interferences occur when the mass-to-charge ratio (m/z) of interfering ions overlap with analyte ions. These interferences are the primary limitation of ICP-MS. Fortunately, there’s a better way. The high mass resolution potential of a sector-field mass spectrometer can physically distinguish and separate an analyte from interferences by exploiting small differences in mass-to-charge. Therefore, high resolution (HR) ICP-MS can quantify concentrations and determine precise isotope ratios for elements across nearly the entire periodic table, regardless of the sample matrix.<figure class="image"><img style="aspect-ratio:779/639;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Element_2_HR_ICP_MS_3960103a20.jpg" alt="Thermo Scientific™ Element XR™ HR-ICP-MS: High mass resolution (R = 10,000) takes advantage of slight mass differences to analyze elements in the most challenging sample matrices. As an example, Arsenic (75As) in a chlorine matrix is masked by argon chloride (40Ar35Cl, 38Ar37Cl) without using high resolution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Element_2_HR_ICP_MS_3960103a20.jpg 190w," sizes="100vw" width="779" height="639"></figure>High mass resolution (R = 10,000) takes advantage of slight mass differences to analyze elements in the most challenging sample matrices. Arsenic (75As) in a chlorine matrix is masked by argon chloride (40Ar35Cl, 38Ar37Cl) without using high resolution. Selenium (Se) is another key element that benefits from high resolution in common matrices. Beyond chloride matrices, high resolution is frequently applied to separate oxide, argide and nitride interferents, as well as multiply charged ions.<ul><li>Low resolution analyzes non-interfered isotopes with the highest sensitivity.</li><li>Medium resolution guarantees interference-free analysis for most elements in the majority of matrix types.</li><li>High resolution provides unequivocal separation of analytes and interferences in the most challenging matrices</li></ul>The simplicity of high-resolution ICP-MS allows the most advanced performance, without compromising on straightforward and reliable method development. This makes the Element series the platform of choice in top-level research and metrology institutions, as well as advanced routine analysis laboratories across the globe.<h3>Features and benefits</h3><ul><li>High mass resolution: Accurately measure isotope signals separate from spectral interferences and produce clean elemental spectra while retaining flexibility.</li><li>Straightforward analytical methods: Providing visual confirmation of accurate measurements.</li><li>Interference removal: no use of reactive gases.</li><li>High sensitivity: Get accurate and precise multi-element analysis down to pg·L-1 concentrations for all resolutions. The Element XR HR-ICP-MS increases the linear dynamic range by an additional three orders of magnitude for maximum flexibility.</li><li>Ideal for transient multi-elemental signals, such as laser ablation, HPLC, GC, CE, FFF.</li><li>High-precision isotope ratios.</li><li>An advanced research tool with the reliability and robustness to serve in 24/7 production control.</li></ul><figure class="image"><img style="aspect-ratio:650/542;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Element_2_HR_ICP_MS_2_b2de21a704.jpg" alt="Thermo Scientific™ Element™ 2 HR-ICP-MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Element_2_HR_ICP_MS_2_b2de21a704.jpg 187w," sizes="100vw" width="650" height="542"></figure><h3>Element XR HR-ICP-MS</h3>The gold standard for full elemental screening in high dynamic range laser ablation and solution work, and for large isotope ratios applications.The combination of a dual-mode SEM with a Faraday detector increases the linear dynamic range by an additional three orders of magnitude. This enables analysis of any matrix element straight without further dilution or precautions to avoid detector damage from inadvertently measuring high level elements.

Thermo Scientific Neoma MS/MS MC-ICP-MS

The Neoma MS/MS MC-ICP-MS is the first dedicated collision/reaction cell MC-ICP-MS with unique pre-cell mass filtering technology, allowing you to separate out isobaric interferences.

<div><div id="product-description">Separate out isobaric interferences to achieve new levels of precision and accuracy in your isotope research. There are some situations when even the highest resolution is not enough and isobaric interferences cannot be resolved, even with the best ICP-MS instruments available. Thermo Scientific™ Neoma™ MS/MS MC-ICP-MS provides the solution.The Neoma MS/MS MC-ICP-MS is the first dedicated collision/reaction cell MC-ICP-MS with unique pre-cell mass filtering technology, allowing you to separate out isobaric interferences and opening up new avenues in the field of laser ablation MC-ICP-MS and beyond.</div><div><h3>Modes</h3><ul><li>Full transmission mode: High-precision isotope analysis without utilizing the collision/reaction cell technology. Additionally, the pre-cell mass filter can be used to remove matrix elements, boosting sensitivity and improving abundance sensitivity.</li><li>Collision/reaction cell mode: For isotope systems with significant isobaric interferences, patented pre-cell mass filter technology removes matrix elements that might act to cause secondary reactions in the CRC.</li></ul><figure class="image"><img style="aspect-ratio:650/468;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Neoma_MS_MS_MC_ICP_MS_0986e1671d.jpg" alt="Thermo Scientific™ Neoma™ MS/MS MC-ICP-MS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Neoma_MS_MS_MC_ICP_MS_0986e1671d.jpg 217w," sizes="100vw" width="650" height="468"></figure><h3>Applications</h3><ul><li>In-situ Rb-Sr dating: Unprecedented precision for dating geological samples by a combination of the pre-cell mass filter, the collision/reaction cell and the multicollector detector array.</li><li>Interference-free Ti isotope analysis: The pre-cell mass filter can be used to remove molecular and doubly charged interferences, and the collision/reaction cell can be used to remove isobaric interferences.</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_001006_sr_ioms_b_isotopes_an001006_en_90167475a4.pdf">In-situ boron isotope analysis of biogenic carbonates</a>: Unprecedented accuracy LA-MC-ICP-MS analysis by using the pre-cell mass filter to remove interferences from scattered Ca4+ ions on 10B</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_001035_ioms_mc_icp_ms_neoma_potassium_an001035_em_en_913d82d28d.pdf">K isotope analysis</a>: Interference of 40Ar+ can hamper the precision and accuracy of the K isotope analysis. Remove the 40Ar+ interference with either: (1) the <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0014262">eXtra High Resolution (XHR)</a> of Neoma MC-ICP-MS, or (2) for smaller sample sizes, the use of H2 and He in the collision/reaction cell to neutralize 40Ar and 40ArH</li></ul><h3>Technology options</h3><ul><li>Extended choice with 24 amplifier array: Ion current amplifiers are mounted in a doubly shielded, evacuated and thermostatted housing with a temperature stability of 0.01°C/hour, to guarantee baseline and gain stability.</li><li>Enhanced variable detector array: Precise alignment of all 11 cups with ion beams of different dispersions to ensure the flexibility to cover isotopic applications from Li through to U, in low or high resolution, and without compromising the native dispersion of the mass analyzer.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0025160">Jet Interface</a>: The Jet Interface, in combination with a desolvating nebulizer system, increases sensitivity by 10 to 20 times compared to standard wet plasma.</li><li>Choice of resolution: 3 different mass resolutions for maximizing the sensitivity of your analysis whilst allowing interferences to be resolved.</li><li>Flexibility of detector types: A flexible, three-detector system spanning &gt;9 orders of magnitude in signal intensity range (1 cps – 6 Gcps). The central channel is equipped with a dual-mode detector that can be switched from Faraday cup to SEM ion counter, and with the proprietary relay matrix, any amplifier can be assigned to any of the Faraday cups via software.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAMGAATFAPTMZZZ">1013Ω amplifier technology</a>: Ensures fast response times with extremely low noise characteristics. The benefits of Faraday cups can be realized at low signal intensities (30 kcps – 3 Mcps), delivering external precisions that approach the ultimate limits of counting statistics.</li></ul></div></div>

Thermo Scientific Neoma multicollector ICP-MS (MC-ICP-MS)

Perform routine isotope analysis or explore novel isotopes in unknown materials using the Thermo Scientific Neoma multicollector ICP-MS (MC-ICP-MS).

<div><div id="product-description">Perform routine isotope analysis or explore novel isotopes in unknown materials using the Thermo Scientific Neoma multicollector ICP-MS (MC-ICP-MS). This ICP-MS system builds on our multicollector technology to deliver all the advantages of high-precision isotope ratio analysis, with none of the limitations. It includes state-of-the art software and hardware, features flexible and sensitive detector technology, a sensitive ion source and excellent mass resolving power, enabling challenging isotope analyses.Now Neoma MC-ICP-MS comes with the upgrade pathway to <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1675">Thermo Scientific™ Neoma™ MS/MS MC-ICP-MS</a>, the first dedicated collision/reaction cell MC-ICP-MS with unique pre-cell mass filtering technology. Allowing you to separate out isobaric interferences and opening up new avenues in the field of laser ablation MC-ICP-MS and beyond.</div><div><h3>Technology that transforms your science</h3>Building on the strength of our multicollector technology, the Neoma MC-ICP-MS system blends the cutting-edge and field-proven technologies found in Thermo Scientific high-resolution isotope ratio mass spectrometers and <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products?category=232&amp;manufacturerItems=3&amp;search=iCAP%E2%84%A2+Qnova">Thermo Scientific™ iCAP™ Qnova ICP-MS systems</a>:<ul><li>Robust iCAP Qnova ICP-MS source</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0025160">Jet interface</a>: for highest sensitivity and stability in wet and dry plasma</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0014262">Extra High resolution (XHR)</a>: enabling hydride interference removal</li><li>Limit breaking detector array: 11 moveable collectors. No limitations</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAMGAATFAPTMZZZ">1013 Ω Amplifier Technology</a> with extended dynamic range</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0024689">Retarding Potential Quadrupole (RPQ)</a>: for excellent abundance sensitivity enabling accurate quantification of extreme isotope ratios</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/BRE0024305">Multi Ion Counting (MIC)</a> packages: dedicated for specific nuclear and geochronology applications.</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">Thermo Scientific™ Qtegra™ Intelligent Scientific Data Solution™ (ISDS) Software</a>: for ultimate ease of use and flexibility in instrument control and method design.</li></ul><figure class="image"><img style="aspect-ratio:650/403;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Neoma_multicollector_ICP_MS_MC_ICP_MS_2_a36be9f4b3.jpg" alt="Thermo Scientific™ Neoma™ multicollector ICP-MS (MC-ICP-MS)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Neoma_multicollector_ICP_MS_MC_ICP_MS_2_a36be9f4b3.jpg 245w," sizes="100vw" width="650" height="403"></figure><h3>High-precision isotope ratio analysis, simplified</h3><ul><li>Delivers performance with market-leading sensitivity, isotope ratio precision and accuracy</li><li>Features the latest hardware and software making the system easier to use than legacy MC-ICP-MS systems</li><li>Offers operator-focused <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1489">software</a>, with integrated first- and third-party peripheral control to streamline workflows and enhance productivity</li><li>Enables high throughput for routine applications while retaining the flexibility required for researching new applications</li></ul><h3>Break through the noise</h3>There are some situations when even the highest resolution is not enough. Isobaric interferences cannot be resolved even with the best ICP-MS instruments available. <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAMGAATFARHMBNK">Thermo Scientific™ Neoma™ MS/MS MC-ICP-MS</a>&nbsp;provides the solution.For users familiar with triple quad ICP-MS technology, the Neoma MS/MS MC-ICP-MS represents the next leap forward in terms of precision and accuracy. With a similar structure of filter, react, separate, the Neoma MS/MS MC-ICP-MS allows for the effective removal of isobaric interferences without compromising sensitivity, with the additional benefit of simultaneous isotope analysis, for ultimate precision and accuracy of your isotope ratio.</div></div>

Products from category ICP/HRMS - page 1

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