<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

<p><strong>Scientists at CEITEC Brno University of Technology have developed microscopic robots that could one day accelerate beer production and simplify food quality control. The magnetically controlled biobots can actively mix liquids during fermentation, speed up the process, and separate themselves from the finished product once fermentation is complete. The results of the research, carried out by Professor Martin Pumera’s team, were published in the journal </strong><i><strong>ACS Nano</strong></i><strong>.</strong></p><p><i>“When people hear the word ‘robot’ today, they often imagine an electronic device. In reality, however, a robot can be any system capable of autonomously performing a specific task,” </i>explains <strong>Martin Pumera of CEITEC Brno University of Technology</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg" alt="CEITEC BUT/Jakub Rozboud: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Martin Pumera in his lab at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg 235w," sizes="100vw" width="1600" height="1067"></p><p>The research team created so-called biobots—biohybrid microrobotic capsules containing brewer’s yeast and magnetic nanoparticles. When the yeast produces carbon dioxide during fermentation, the resulting bubbles cause the biobots to move up and down through the liquid. This naturally mixes the contents of the vessel and makes fermentation more efficient. Compared with conventional static particles, the biobots can therefore accelerate chemical processes that are important in food production.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Hematite microrobot (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg 209w," sizes="100vw" width="1600" height="1192"></p><p>Another major advantage of the technology is that the biobots can be easily separated from the finished beverage. Thanks to the magnetic particles they contain, they can be controlled with a magnetic field and removed once fermentation is complete, eliminating the need for additional filtration. The researchers also demonstrated that the biobots can be reused over several production cycles.</p><p><i>“Unlike conventional static particles, microrobots actively move throughout the entire volume of the liquid, allowing them to cover a larger area and make the whole process more efficient. At the same time, they also facilitate the automation of production,”</i> adds Martin Pumera. The team is currently discussing potential applications of the technology with a major European brewery.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: g-C₃N₄ microrobots (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg 158w," sizes="100vw" width="1476" height="1460"></p><p>Martin Pumera’s group has long been exploring the use of microrobots and advanced materials in the food industry. In the past, for example, the team developed a flexible sensor for smart packaging capable of detecting spoiled fish. The new biobots therefore represent another step towards more advanced methods of food quality and safety control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg" alt="CEITEC BUT/ACS Nano: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: ACS Nano - cover featuring article by Martin Pumera et al." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg 117w," sizes="100vw" width="1600" height="2128"></p>

 CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control 

<p><strong>In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with Michelle Taylor, Editor-in-Chief of LabCompare, to go behind the scenes of their groundbreaking two-part documentary series on PFAS (per- and polyfluoroalkyl substances).</strong></p><p>The conversation kicks off with a startling revelation: many of the world’s leading PFAS experts have completely stopped eating seafood due to high contamination levels discovered during testing. From there, we dive deep into the technical and regulatory challenges facing today's analytical laboratories.</p><h4><strong>In this episode, we discuss:</strong></h4><ul><li><strong>The Laboratory Throughput Crisis:</strong> Why labs are currently "overwhelmed with samples" and how tiered testing—using single quad instruments for screening before moving to triple quads—is helping to manage capacity without sacrificing sensitivity.</li><li><strong>The Battle Against Background Contamination:</strong> Why PTFE-free (PFAS-free) laboratory equipment is no longer optional when trying to detect "forever chemicals" at the parts-per-trillion and parts-per-quadrillion levels.</li><li><strong>Complex Matrices (Seafood &amp; Packaging): </strong>The technical hurdles of analyzing high-lipid samples like fish and the rising demand for migration testing as states like Rhode Island begin to phase out PFAS in food packaging.</li><li><strong>Global Regulatory Shifts:</strong> A look at the "dual compliance model" required for labs supporting international exporters, especially with the European Union’s stricter enforcement compared to the U.S. monitoring approach.</li><li><strong>The "Grand Challenge" of Unknowns: </strong>How EPA Method 1621 (Total Organic Fluorine) is helping labs close the mass balance gap and why the next generation of bench chemists must embrace *AI and data science* to manage the massive datasets generated by high-resolution mass spectrometry.</li><li><strong>PFAS Destruction vs. Remediation:</strong> &nbsp;The promising (and problematic) methods for breaking the carbon-fluorine bond, and why incineration may inadvertently be spreading shorter-chain PFAS into the air.</li></ul><p>Whether you are a lab manager looking to future-proof your workflow or a chemist navigating the ever-evolving landscape of EPA Method 1633, this episode provides essential insights into the most pressing environmental crisis of our time.</p><h3><strong>Video Transcription</strong></h3><h4><strong>Michelle Taylor: PFAS Testing Is Becoming a Much Bigger Analytical Challenge</strong></h4><p><strong>PFAS analysis has rapidly evolved from a specialized environmental testing problem into a much broader challenge involving drinking water, food, packaging, laboratory contamination, international regulation, data analysis, and even destruction technologies. In an interview with Michelle Taylor, Editor-in-Chief of Labcompare, the discussion explored what laboratories are learning from the latest PFAS research—and why the analytical demands are likely to continue growing.</strong></p><p>Taylor leads editorial content for <strong>Labcompare</strong>, an online resource covering analytical laboratory instrumentation, products, and scientific developments. Among the projects she considers particularly important are two long-form documentaries produced by Labcompare examining per- and polyfluoroalkyl substances (PFAS), first through drinking water and subsequently through food.</p><p>The documentaries brought together subject-matter experts working across PFAS analysis and exposed some of the practical realities laboratories now face: rapidly changing regulations, extremely low detection limits, complex matrices, contamination risks, and sample volumes that can overwhelm laboratory capacity.</p><h4><strong>From drinking water to seafood</strong></h4><p>One of the most memorable findings for Taylor came during production of the second documentary, which focused on PFAS in food.</p><p>Several experts interviewed for the project told her they had stopped eating seafood, in some cases many years earlier, because of concerns surrounding contamination. For Taylor, the consistency and immediacy of those responses illustrated how closely analytical research can intersect with everyday decisions.</p><p>Seafood also demonstrates why PFAS testing can become analytically difficult.</p><p>Fish and other high-lipid samples require effective extraction to release the analytes, followed by rigorous cleanup to remove fats. According to the experts Taylor interviewed, the cleanup step is particularly critical because residual lipids can damage LC columns and create severe matrix interferences.</p><p>Laboratories are therefore using approaches such as enhanced matrix removal and carbon- or silica-based sorbents to reduce the lipid content of extracts before instrumental analysis. The goal is not simply obtaining sufficient recovery, but producing an extract clean enough to maintain analytical performance and laboratory throughput.</p><h4><strong>How laboratories are handling the PFAS sample burden</strong></h4><p>The analytical sensitivity now required for PFAS testing presents another challenge: laboratories may need to measure compounds at <strong>parts-per-trillion levels</strong> while processing growing numbers of samples.</p><p>Automation has therefore become increasingly important, particularly during sample preparation, where repetitive manual procedures can otherwise create a major bottleneck.</p><p>Taylor also described a <strong>tiered analytical strategy</strong> being used by some laboratories. A less demanding measurement can first be used for screening, while samples generating a positive result are subsequently transferred to a more sensitive platform, such as triple-quadrupole mass spectrometry, for confirmation and quantitation.</p><p>This type of workflow can help laboratories concentrate their highest-performance instrumentation on the samples that actually require it rather than applying the most intensive analysis to every incoming sample.</p><p>The broader principle is likely to become increasingly important as PFAS testing expands: laboratories must find ways to increase throughput without sacrificing the sensitivity demanded by regulatory methods.</p><h4><strong>When the laboratory itself becomes a source of PFAS</strong></h4><p>At trace concentrations, contamination introduced during sample preparation or measurement can become comparable to the concentration being determined.</p><p>This makes the materials used throughout the analytical workflow particularly important.</p><p>Taylor emphasized that PFAS laboratories must maintain continuous awareness of potential contamination from <strong>solvents, water, tubing, containers, and other laboratory components</strong>. Equipment containing fluoropolymers such as PTFE may be problematic in certain PFAS workflows because background contamination can contribute to false positives or elevated blanks.</p><p>As detection limits move lower, dedicated PFAS-compatible or fluoropolymer-free laboratory equipment becomes increasingly valuable.</p><p>Taylor described manufacturers offering clearly identified PFAS-free configurations as an important response to this problem. Rather than forcing laboratories to investigate the material composition of each component individually, dedicated configurations can simplify method implementation and reduce uncertainty about potential background sources.</p><p>For laboratories already dealing with demanding workflows and large sample loads, eliminating potential contamination before it occurs can save considerable troubleshooting time.</p><h4><strong>Food packaging could drive the next major wave of testing</strong></h4><p>PFAS concerns are not limited to the food itself.</p><p>The interview also examined <strong>food-contact materials</strong>, including takeout containers and other packaging from which PFAS may migrate into food. State-level restrictions in the United States are already beginning to affect the materials manufacturers can use.</p><p>For contract laboratories, this creates the possibility of another significant increase in demand for compliance and migration testing.</p><p>Taylor’s recommendation is straightforward: laboratories should follow proposed regulations before they become final.</p><p>Waiting until a new requirement takes effect can leave a laboratory simultaneously trying to acquire instrumentation, establish methods, train staff, and respond to customer demand. Monitoring regulatory agencies, scientific meetings, and industry discussions earlier gives laboratories time to prepare analytical capabilities before the testing requirement becomes urgent.</p><p>She expects PFAS restrictions in food packaging to continue developing first through a patchwork of individual state regulations. Once a sufficient number of states adopt restrictions, however, the economics may increasingly encourage suppliers to move toward PFAS-free materials regardless of whether every jurisdiction requires them.</p><p>A national standard could eventually follow that transition.</p><h4><strong>One sample, two regulatory environments</strong></h4><p>International food exporters face another complication: <strong>PFAS requirements are not necessarily the same between the United States and European Union</strong>.</p><p>Taylor noted that laboratories serving both markets may effectively need to operate under a dual-compliance model.</p><p>In the interview, she highlighted EU requirements targeting specific PFAS—including <strong>PFOS, PFOA, PFNA, and PFHxS</strong>—at very low concentrations in certain foods, while the U.S. approach has historically involved a different combination of monitoring programs, evolving compound lists, and import-related requirements.</p><p>For laboratories supporting international customers, this means more than simply selecting a different reporting limit.</p><p>Different markets may require different target lists, methods, documentation, auditing, and compliance procedures. Laboratories therefore need analytical platforms capable of ultratrace measurements while also maintaining the operational flexibility to support multiple regulatory frameworks.</p><p>That additional complexity also carries a practical cost: performing different protocols for different jurisdictions means more staff time, additional workflow management, and potentially greater instrument demand.</p><h4><strong>Total fluorine screening can help laboratories decide what to analyze next</strong></h4><p>Targeted LC-MS/MS methods are highly sensitive, but they only measure compounds included in the analytical panel.</p><p>This creates an important question: <strong>what about fluorinated substances that are present but are not included in the targeted method?</strong></p><p>The interview discussed <strong>EPA Method 1621</strong>, which uses a broader fluorine-based screening approach. Taylor described this type of measurement as useful for helping laboratories assess the gap between compounds captured by targeted LC-MS/MS methods and the broader amount of organofluorine present in a sample.</p><p>Such screening can also become part of a tiered workflow.</p><p>For applications such as food packaging, laboratories could initially use a broader fluorine measurement to determine whether a sample warrants further investigation. Positive or suspicious samples could then move to more selective and sensitive targeted analysis for identification and quantitation.</p><p>Non-targeted high-resolution mass spectrometry can add another layer by revealing compounds outside conventional target lists.</p><p>Together, these approaches create a funnel from broad screening toward increasingly detailed characterization rather than attempting the most comprehensive analysis on every sample from the outset.</p><h4><strong>PFAS analysis is becoming a data problem too</strong></h4><p>High-resolution mass spectrometry can generate enormous datasets containing signals from large numbers of known and unknown compounds.</p><p>As a result, Taylor believes the role of the analytical chemist is changing.</p><p>Strong laboratory skills remain essential, but scientists increasingly need <strong>data literacy</strong> as well. Understanding complex datasets, working with advanced software, and interacting effectively with artificial intelligence and machine-learning tools are becoming important parts of modern analytical work.</p><p>Taylor does not see this change primarily as replacing scientific expertise.</p><p>Instead, she compares it with earlier laboratory automation: repetitive or technically demanding tasks can increasingly be handled by software, allowing scientists to spend more time interpreting results and making decisions.</p><p>AI may also make sophisticated analytical information more accessible. A less experienced mass spectrometry user could potentially receive explanations of complex data through software capable of presenting results in natural language, reducing dependence on a single specialist being immediately available.</p><p>There is another potential advantage beyond speed.</p><p>Machine-learning systems can recognize patterns across large datasets that may be difficult or impossible for an individual scientist to detect manually. As analytical datasets become larger and multidimensional, that pattern-recognition capability could become increasingly valuable.</p><h4><strong>Finding PFAS is only the first half of the problem</strong></h4><p>For years, much of the PFAS discussion has focused on answering two questions:</p><ul><li><strong>Are PFAS present, and how much is there?</strong></li></ul><p>The next challenge is considerably harder: <strong>how do we actually remove or destroy them?</strong></p><p>Taylor described this as an expanding research field that will increasingly involve analytical laboratories.</p><p>The strength of the carbon-fluorine bond makes PFAS destruction difficult. Some treatment approaches seek to break this bond and achieve complete defluorination, but incomplete destruction can create another analytical problem.</p><p>For example, thermal treatment may transform longer-chain PFAS into shorter-chain fluorinated compounds rather than eliminating them completely. Those products may then enter another environmental compartment, including atmospheric emissions.</p><p>Consequently, laboratories studying PFAS destruction must do more than measure disappearance of the original compound. They also need to determine whether <strong>fluorinated transformation products or other byproducts remain</strong>.</p><p>Analytical chemistry therefore has two roles: monitoring PFAS contamination and demonstrating whether remediation technologies truly destroy the substances they are intended to remove.</p><h4><strong>The PFAS problem is expanding beyond water and food</strong></h4><p>The first two Labcompare documentaries focused primarily on <strong>water and food</strong>, two matrices already receiving substantial regulatory and public attention.</p><p>But Taylor does not expect the story to end there.</p><p>If Labcompare produces another PFAS documentary, she sees <strong>PFAS in air</strong> as a likely subject. Discussions with experts during earlier filming repeatedly raised atmospheric contamination, including both direct environmental occurrence and emissions potentially associated with treatment or destruction processes.</p><p>The progression illustrates how quickly the PFAS field is expanding.</p><p>Drinking water regulation accelerated analytical development. Food testing introduced more difficult matrices and new exposure pathways. Packaging is creating another compliance challenge. Environmental remediation raises questions about destruction products. Atmospheric monitoring could become another significant frontier.</p><p>For laboratories already working with chromatography and mass spectrometry, Taylor’s message is essentially to be prepared—even organizations that do not currently consider themselves “PFAS laboratories” may eventually become involved.</p><h4><strong>An analytical field that is still changing rapidly</strong></h4><p>Perhaps the strongest theme running through the interview is that PFAS analysis has no fixed endpoint yet.</p><p>Methods continue to evolve. Regulations change. Target compound lists expand. Instrument sensitivity improves. Laboratories discover new sources of background contamination, while researchers identify additional exposure pathways and investigate new destruction technologies.</p><p>Taylor compares the situation to earlier periods of rapid analytical development, such as the evolution of forensic DNA analysis: each technological advance reveals more information, which in turn creates new questions and new analytical requirements.</p><p>That makes preparation particularly important.</p><p>Laboratories cannot predict every future regulation, but they can follow proposed requirements, develop flexible workflows, invest in contamination control and data capabilities, and understand how their existing chromatography and mass spectrometry expertise could be applied to emerging PFAS challenges.</p><p>The analytical problem is no longer simply detecting a group of “forever chemicals.”</p><p>It is becoming a much larger question of <strong>how we identify them, quantify them, prevent contamination during analysis, understand their movement through food and the environment, comply with evolving regulations, and ultimately prove that they have actually been destroyed.</strong></p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

PFAS in Water, Food & Packaging: Michelle Taylor on the "Forever Chemicals" Documentary Series

Article

Scientists

Environment

Water

Interview

Science and research

Video

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer

Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows.

<h4><strong>Superior performance in your routine quantitative analyses</strong></h4><p><strong>Expanding your analytical capabilities with the next step in detection, the Xevo TQ-XS offers superior performance for your routine quantitative workflows. &nbsp;With solutions for today’s needs and technologies to overcome tomorrow’s challenges, explore what the adaptable, flexible, and proven Xevo TQ-XS Tandem Quadrupole Mass Spectrometer coupled with ACQUITY UPLC can afford your laboratory’s productivity and capabilities. &nbsp;</strong></p><div><div><div><div><ul><li><strong>Expanding your efficiencies</strong>: Maximize your laboratory’s potential in high sensitivity quantitative analysis by extending your capabilities, confidently and productively</li><li><strong>Performance that’s proven</strong>: Trust the proven Xevo TQ-XS to meet the analytical demands of your challenging applications , injection after injection</li><li><strong>Digesting your data</strong>: Reduce the burden in data handling with flexible and adaptable software solutions to meet your application and quality system needs</li><li><strong>Supporting your success</strong>: Have confidence that you will exceed your analytical requirements using Waters end to end solutions with flexible service and application focused training and support</li></ul></div></div><div><div><h5><strong>Recommended Use</strong></h5><p>Quantitative analysis where <strong>high sensitivity instrument performance</strong> is required (e.g.,&nbsp;to reach <strong>low level concentrations (ppt)</strong>).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: The Xevo TQ-XS System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_5e2d4a8690.jpg 245w," sizes="100vw" width="1024" height="545"></p><div><div><h3><strong>Expand your analytical capabilities with enhanced sensitivity</strong></h3><p>Delivering the next step in reliable sensitivity, the <strong>Xevo TQ-XS</strong> enables your laboratory to expand your analytical capacity and productivity. Whether seeking more sensitivity to detect your analytes routinely, looking to extend your scope of analytes with increased confidence or revise your workflow to reduce time and costs, explore what <strong>Xevo TQ-XS</strong>, coupled with <strong>ACQUITY UPLC</strong> and <strong>ACQUITY Premier Systems</strong> can offer your lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Vancomycin: Xevo TQ-XS versus Xevo TQ-S. On average, the analyte area counts on Xevo TQ-XS were >10x higher than area counts on Xevo TQ-S for Vancomycin." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_2_53f3f2443c.jpg 245w," sizes="100vw" width="1024" height="295"></p></div></div><div><div><h3><strong>Proven performance you can trust for your challenging analyses</strong></h3><p>Whether looking to streamline your methods or advance your laboratory’s performance, explore how <strong>Xevo TQ-XS</strong>, coupled with <strong>LC (UPLC), GC (APGC) or SFC (UPC2)</strong> can benefit your challenging applications. Trust the proven <strong>Xevo TQ-XS</strong> to meet your <strong>analytical demands</strong>, injection after injection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: Representative liraglutide LLOQ (0.5 ng/mL) chromatogram, extracted from plasma, demonstrating sensitivity and selectivity with Xevo TQ-XS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_3_fdd2e3d239.jpg 245w," sizes="100vw" width="1024" height="536"></p></div></div><div><div><h3><strong>Software solutions to overcome a common bottleneck</strong></h3><p>While quantitation of targeted analytes can be a routine experiment, the volume of data acquired and generated for processing, review and management can be significant. <strong>Waters</strong>’ informatics platforms offer extensive toolsets to support efficient and compliant <strong>data handling</strong> to support your <strong>21 CFR 11 and ISO 17025</strong> environments.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg" alt="Waters Xevo TQ-XS Triple Quadrupole Mass Spectrometer: With the Xevo TQ-XS System, you’ll get robust results you can trust with the most demanding sample matrices." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_XS_Triple_Quadrupole_Mass_Spectrometer_4_a3e46ecd44.jpg 234w," sizes="100vw" width="1024" height="683"></p></div></div><div><div><h3><strong>Accelerating your success with award winning service</strong></h3><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with Waters comprehensive analytical solutions with expert training (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services.html"><strong>APS</strong></a>) and flexible and cost-effective solutions to advance your business with system service <strong>(</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/global/services/instrument-services/flexchoice-instrument-service-coverage.html"><strong>FlexCHOICE</strong></a>), trade-ins and technological upgrades (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/FlexUP-Technology-Renewal-Program-%7C-Upgrade-Lab-Instruments/nav.htm?cid=135071972"><strong>FlexUP</strong></a>).</p></div></div></div></div></div></div>

Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.

<h3><strong>Defining Compact Performance</strong></h3><ul><li><strong>Robust Sensitivity Beyond Expectations</strong></li></ul><p><strong>From the inherently robust Xevo family, the Xevo TQ-S micro tandem quadrupole mass spectrometer provides superior performance per square inch and exceptional analytical flexibility.</strong></p><h4><strong>Reliable performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S micro study analyzing mycotoxins in wheat flour (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1000 injections and only 5-9% relative standard deviation (RSD) for peak areas.</p><h4><strong>Maximizing uptime</strong></h4><p>Get the most from your instrument and avoid time-consuming repair visits. Customers using the Xevo TQ-S micro will on average not need an unplanned service visit during the warranty period and for 3 years after.<strong>*</strong>&nbsp;</p><p><strong>*</strong>Source Waters internal service data on unplanned service visits for Xevo TQ-S micro issues that occur globally. Note that warranty period used is 1 year and planned visits for regular scheduled Performance Maintenance are recommended to ensure trouble-free operation</p><h4><strong>Achieve more with less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S micro is 2-3X narrower than other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S micro provides up to 34% lower electricity power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: With benchspace at a premium, choose an instrument designed to maximize performance per square inch." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_15dba17d1b.jpg 245w," sizes="100vw" width="1024" height="300"></p><h4><strong>Flexibility to meet your analytical needs&nbsp;</strong></h4><p>With the most commonly used atmospheric pressure ionization source of ESI as standard, simply change chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S micro provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S micro won’t let you down.</p><p><strong>Experiment 1</strong> – 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 5-9% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_ad4c8cbe77.jpg 245w," sizes="100vw" width="1221" height="647"></p><p><strong>Experiment 2</strong> – Acetaminophen in protein precipitated plasma also showed consistent performance over 6 ½ days of continuous use with 2,400 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Experiment 2 - Acetominophen in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Acetominophen_in_protein_precipitated_plasma_0e5b14e7ac.jpg 245w," sizes="100vw" width="1220" height="649"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022.</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower Operational Costs and Improved Sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability while balancing the need to continually reduce operational costs. The Xevo TQ-S micro consumes less electricity than other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><p><strong>Table 1:</strong> Instrument / Power Consumption / Heat Output</p><ul><li><strong>Waters Xevo TQ-S micro</strong> / 1250 W / 4,263 Btu/h</li><li><strong>Competitor B</strong> / 1452 W / 4,950 Btu/h</li><li><strong>Competitor A</strong> / 1600 W / 5,456 Btu/h</li><li><strong>Competitor C</strong> / 1960 W / 6,500 Btu/h</li></ul><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S micro Site Preparation Guide</strong></a><br>Note that power stated for scroll pump configuration. Option for rotary pump configuration is available</p><p>Power and heat outputs for mid tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve More with Flexible Software Solutions</strong></h4><p>The Xevo TQ-S micro is available on both the waters_connect™ and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><ul data-spread="false"><li><strong>waters_connect™:</strong> Our modern, app-based software platform delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time.</li><li><strong>MassLynx™: </strong>A well-established software package delivering market-leading versatility and flexibility for all application areas.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems and APGC™. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S micro Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S micro, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S micro into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S micro – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer

Quantitate with Absolute Power: up to 15× higher sensitivity, 6× longer uptime, and 50% less energy use. The Xevo TQ Absolute XR delivers eXtreme Robustness in a compact design.

<h4><strong>Quantitate with Absolute Power and eXtreme Robustness</strong></h4><p><strong>Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR instrument.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg" alt="Waters: Xevo TQ Absolute XR Triple Quadrupole MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg 245w," sizes="100vw" width="1603" height="900"></p><p>Engineered for maximum productivity in a compact, sustainable design, the Waters Xevo TQ Absolute XR instrument features the new <strong>StepWave XR ion guide</strong> for enhanced resilience against contamination, even with high-throughput, complex sample matrices. That means more uptime, fewer interventions, and lab performance you can trust, all while aligning with your environmental, social, and governance (ESG) goals.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg" alt="Waters: StepWave XR ion guide" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg 245w," sizes="100vw" width="936" height="388"></p><h4><strong>Overview</strong></h4><ul><li><strong>Absolute confidence: </strong>Experience up to six times more robustness<sup>1</sup> with the new StepWave XR ion guide, designed for superior resilience to contamination. The Xevo TQ Absolute XR Mass Spectrometer ensures consistent, reliable performance, even under the most challenging analytical conditions.</li><li><strong>Absolute performance: </strong>Push quantitation limits further and meet stringent regulatory requirements with up to 15x greater sensitivity<sup>2</sup> for difficult-to-ionize negative mode compounds, setting a new benchmark in high-performance quantitation.</li><li><strong>Absolute efficiency: </strong>Reduce your laboratory’s environmental impact and operational costs with a mass spectrometer that consumes up to 50% less electricity and gas while generating 50% less heat than other high-performance TQ instruments.</li><li><strong>Absolute productivity: </strong>Streamline data analysis with waters_connect software, featuring Exception Focused Review (XFR) functionality to accelerate workflows, cutting data review time by up to 50% for more efficient, accurate results.</li><li><strong>Absolute versatility:</strong> Choose from our differentiated range of source options to find the technology most suited to your applications including DESI XS, APGC, and UniSpray.</li></ul><p><i><strong><sup>1</sup></strong>In a well-controlled experiment, performance was maintained for up to six times the duration on the Xevo TQ Absolute XR compared to the Xevo TQ Absolute; more than 12,000 samples of pesticides in fish feed matrix were analyzed</i></p><p><i><strong><sup>2</sup></strong>Compared to previous generation high performance tandem mass spectrometer, the Xevo TQ-XS.</i></p><ul><li><strong>Recommended Use: </strong>Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.</li></ul><h5><strong>Ensure Absolute confidence with eXtreme Robustness</strong></h5><p>The Xevo TQ Absolute XR Mass Spectrometer analyzes up to six times more samples before service maintenance is required. Get the answer right first time and reduce unplanned downtime! This is one example of multiresidue pesticide analysis in a complex matrix (fish feed), for more examples please visit the brochure.</p><h5><strong>Accelerated Multiresidue Pesticides study</strong></h5><p>Fish feed, an example of a complex, challenging matrix, was tested using QuEChERS extraction without cleanup and without a divert-to-waste step. The Xevo TQ Absolute instrument demonstrated robust performance, operating effectively for approximately 1,500–2,000 injections (~3 months of continuous use1) before any signs of quadrupole charging appeared. The Xevo TQ Absolute XR mass spectrometer further extends this robustness, maintaining stable performance beyond 12,000 injections. Both instruments successfully handled over 400 MRMs in under 6 minutes, with no need for instrument venting for cleaning during the study.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg" alt="Waters: The Xevo TQ Absolute mass spectrometer began to show signs of quadrupole charging after approximately 1,500–2,000 injections of fish feed matrix (represented here by fluazinam; equivalent to ~3 months of use*). In contrast, the Xevo TQ Absolute XR system maintained system performance well beyond 12,000 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg 234w," sizes="100vw" width="1280" height="853"></p><h5><strong>Achieve Absolute performance with improved sensitivity</strong></h5><p>To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg" alt="Waters: The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg 245w," sizes="100vw" width="1280" height="676"></p><h5><strong>Realize Absolute efficiency and lower operational costs</strong></h5><p>Many businesses are trying to actively address environmental sustainability while also reducing operational costs – and the Xevo TQ Absolute XR instrument helps make that possible.</p><p>With lower electricity consumption, gas consumption, and BTU/hr output, it lessens the demand for air conditioning and drives down energy costs. The minimized LC-MS/MS footprint of the Xevo TQ Absolute XR Mass Spectrometer delivers more analytical power per square foot, enabling lab managers to maximize space and drive greater operational efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg" alt="Waters: The Xevo TQ Absolute XR instrument offers strong performance with less energy consumption in a compact form factor compared to today’s average high-end and high-end MS/MS systems, per data from published vendor site installation guides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg 245w," sizes="100vw" width="1280" height="622"></p><h5><strong>Achieve Absolute productivity with flexible software options</strong></h5><p>Unlock the full potential of the instrument when paired with our next-generation solution software. From automated data processing to the time-saving Exception Focused Review (XFR) feature, you’ll streamline data review time by up to 50% and spend more time advancing your science.</p><p>Built on a secure, traceable platform, waters_connect for Quantitation is built to accelerate your LC-MS/MS workflows. giving you the absolute confidence to scale, adapt, and lead in any environment.</p><p>For labs that need proven versatility across applications, the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>Waters MassLynx Software</strong></a> continues to deliver time-tested flexibility and control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg" alt="Waters: The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute XR provides absolute productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg 234w," sizes="100vw" width="1024" height="682"></p><h5><strong>Accelerating your success with award-winning service</strong></h5><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with the Waters comprehensive analytical solutions with expert training (<strong>APS</strong>) and flexible and cost-effective solutions to advance your business with system service (<strong>FlexCHOICE</strong>), trade-ins and technological upgrades (<strong>FlexUP</strong>).</p><h5><strong>Cover more applications from our range of complementary technologies</strong></h5><p>Choose from our comprehensive range of ionization technologies providing differentiated application coverage to get the most from your analyses.</p><ul><li><strong>UniSpray</strong> - Absolute potential unlocked. Enable your lab to improve process efficiency through potential gains in sensitivity, precision and reduced matrix effects, relative to the equivalent electrospray ionization source option.3</li><li><strong>APGC </strong>- The next generation of GC is already here with Atmospheric Pressure Gas Chromatography offering labs absolute power - a powerful alternative to electron ionization technology, enabling low limits of detection, confident compound identification, and confirmation.</li><li><strong>DESI XS</strong> - With a combination of mass spectrometry imaging (MSI) and tandem quadrupole mass spectrometry, a remarkable technique emerges to perform sensitive, fast, and quantitative MSI directly on sample surfaces.&nbsp;</li></ul>

Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry

From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.

<h3><strong>Transform your Quantitative Capabilities</strong></h3><ul><li><strong>Affordable Reliable Performance</strong></li></ul><p><strong>From the inherently robust Xevo family of tandem quadrupole instruments, the Xevo TQ-S cronos provides reliable performance at an attractive price point.</strong></p><h4><strong>Reliable Performance</strong></h4><p>Achieve your objectives in full with operational performance you can rely on. A Xevo TQ-S cronos study analyzing mycotoxins in cereal (a complex matrix that can contaminate LC/MS instrumentation) showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% relative standard deviation (RSD) for peak areas.</p><h4><strong>Affordable Performance</strong></h4><p>Cover your key applications with a robust and cost-efficient instrument that delivers reliable results. The Xevo TQ-S cronos can be applied to key demanding applications such as the quantification of nitrosamines in drug products and quantification of pesticides in fruits, vegetables, and cereals.</p><h4><strong>Cover a Wider Variety of Compounds in One Analysis</strong></h4><p>Choose the UniSpray source option to include ESI and non-ESI amenable compounds in one injection rather than changing chromatographic inlet or ionization source to extend your analytical capacity and meet changing demands.</p><h4><strong>Achieve More with Less</strong></h4><ul data-spread="false"><li>The Xevo TQ-S cronos is 2-3X narrower than most other instruments in its class, reducing laboratory space overhead costs.</li><li>Use of the Xevo TQ-S cronos provides up to 35% lower electrical power consumption and associated heat production than other instruments in its class.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry - With benchspace at a premium, choose an instrument designed to maximize performance per square inch..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_With_benchspace_at_a_premium_choose_an_instrument_designed_to_maximize_performance_per_square_inch_03f4497b5f.jpg 245w," sizes="100vw" width="1024" height="281"></p><h3><strong>Reliable Performance</strong></h3><h4><strong>Keeping Variability to a Minimum</strong></h4><p>Be confident that you will have reliable data over multi-day studies. Two experiments using the Xevo TQ-S cronos provide evidence for the longer-term stability of this instrument. By monitoring peak areas whilst running continuous injections, you can see that the Xevo TQ-S cronos won't let you down.</p><p><strong>Experiment 1:</strong> 4 mycotoxins in wheat flour showed consistent performance over 5 days of continuous use with 1,000 injections and only 3-8% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 1 showing data for mycotoxins in wheat flour." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_1_showing_data_for_mycotoxins_in_wheat_flour_47b4a3d71b.jpg 245w," sizes="100vw" width="1201" height="637"></p><p><strong>Experiment 2:</strong> Sulfadimethoxine in protein-precipitated plasma also showed consistent performance over 3 days of continuous use with 1,780 injections and only 4% RSD for peak areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Experiment 2 - Sulfadimethoxine in protein precipitated plasma." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Experiment_2_Sulfadimethoxine_in_protein_precipitated_plasma_25675e4fc5.jpg 245w," sizes="100vw" width="1200" height="636"></p><p><strong>Less than 1%</strong> of Waters tandem quadrupole mass spectrometers require a detector replacement on an annual basis.<strong>*</strong></p><p><strong>*</strong>Source: Waters internal data on the service history of its tandem quadrupole mass spectrometers launched between 2006 and 2022</p><h3><strong>Improving Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with its customers: to leave the world a better place than we found it. Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. The Xevo TQ-S cronos consumes less electricity than most other instruments in its class and therefore produces less heat – lessening the need for air conditioning and lowering costs.</p><h5><strong>Table 1: Instrument / Power Consumption (W) / Heat Output (Btu/h)</strong></h5><ul><li><strong>Competitor B</strong> / 1,100 / 3,700</li><li><strong>Waters Xevo TQ-S cronos*</strong> / 1,230 / 4,194</li><li><strong>Competitor A</strong> / 1,600 / 5,456</li><li><strong>Competitor C</strong> / 1,960 / 6,500</li></ul><blockquote><p><strong>*</strong><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/account/sign-in.html"><strong>Xevo TQ-S cronos Site Preparation Guide</strong></a></p><p>Power and heat outputs for entry tier TQ products, conversion factor 1W = 3.41 Btu/h</p></blockquote><h3><strong>Ultimate Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ-S cronos is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements.</p><p><strong>waters_connect: </strong>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><p><strong>MassLynx:</strong> Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Flexibility</strong></h3><h4><strong>Choose the Optimal Separation and Ionization Technique for Your Application</strong></h4><p>Waters' market-leading separation technologies include the ACQUITY™ UPLC™ family of LC systems. Application flexibility is further enhanced by the range of quickly interchangeable ion source options made possible by universal ion source architecture.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UPLC/MRM data on Xevo TQ-XS with UniSpray ion source showing improved sensitivity for three compounds that would typically require a change in ionization technique for optimal analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_UPLCMRM_data_on_Xevo_TQ_XS_4f0ea1bc1f.jpg 245w," sizes="100vw" width="1024" height="384"></p><p data-pm-slice="1 1 []"><strong>UniSpray™</strong> A novel ionization technique, exclusive to Waters, with wide compound coverage and potential sensitivity benefits. With applicability over a broad range of analytes and a simplified probe design, you can spend less time changing sources and performing maintenance, and more time analyzing your samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg" alt="Waters Xevo TQ-S cronos Triple Quadrupole Mass Spectrometry: UniSpray." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_cronos_Triple_Quadrupole_Mass_Spectrometry_Uni_Spray_9cedf20611.jpg 235w," sizes="100vw" width="1465" height="974"></p><h3><strong>Optimal Support</strong></h3><h4><strong>Ensure Your Success with World-Renowned Services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ-S cronos, you can:</strong></p><h4><strong>Get up and running quickly&nbsp;</strong></h4><p>Get onsite training and consultation to integrate the Xevo TQ-S cronos into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet your lab’s unique requirements</strong></h4><p>Protect your high-performance instrument investment with comprehensive &nbsp;portfolio of service plans such as Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitate compliance</strong></h4><p>Simplify the process of qualification, validation, and recordkeeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce total cost of ownership</strong></h4><p>FlexCAPITAL™<strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage your existing technology</strong></h4><p>With the FlexUP™ technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ-S cronos – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>**</strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo TQ-GC Mass Spectrometry System

The Xevo TQ-GC allows routine quantitation of multiple contaminants in matrix sample. The consistent high performance allows regulatory limits to be comfortably passed reducing the need for frequent user intervention and re-optimization.

<div><div><h4><strong>The perfect addition to your laboratory</strong></h4></div></div><div><div><p><strong>Demands to meet regulations are increasing pressure on laboratories, and in order to meet these challenges laboratories must develop and run methods that provide high-quality, consistent results, day in and day out.&nbsp;</strong></p><div><div><div><div><p>The <strong>Xevo TQ-GC</strong> is a robust <strong>Electron Ionization (EI) and Chemical Ionization (CI)</strong> Gas Chromatography (GC)-MS/MS platform that allows <strong>routine quantification of multiple contaminants in complex matrices</strong>. The <strong>Xevo TQ-GC</strong> consistently <strong>surpasses the sensitivity required to meet regulatory limits</strong>, thus reducing the need for frequent user intervention and re-optimization. In addition, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>MassLynx Software </strong></a><strong>security</strong> controls user access, giving you more control to assist with laboratory compliance.</p><p>Laboratories can also <strong>develop methods rapidly using Quanpedia</strong>, which allows fast response to changes in legislative demands and for customized methods. All the speed, sensitivity, and reliability you have come to expect from Xevo now with GC-MS/MS.</p><ul><li><strong>Reduce training time and costs</strong> with a single software workflow for GC-MS/MS and LC-MS/MS analysis</li><li><strong>Achieve comprehensive application coverage</strong> powered by Quanpedia database driven workflow</li><li><strong>Easily surpass regulatory limits</strong> with fit-for-purpose performance in difficult matrices</li><li><strong>Choose from a wide range of injection modes</strong>, including liquid, headspace, and solid phase microextraction (SPME) analysis</li><li><strong>Control access to the GC-MS system</strong> to meet regulatory requirements with MassLynx security</li><li><strong>Simplify maintenance tasks</strong> with a rapid and mistake-proof source design</li></ul></div></div><div><div><h4><strong>Recommended Use</strong></h4><p>For routine quantitation of multiple contaminants in an extracted matrix sample.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_4_fda01dffa7.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_4_fda01dffa7.jpg 245w," sizes="100vw" width="1024" height="606"></p><div><div><h3><strong>Maximize uptime to ensure your success</strong></h3><p>Ensuring you achieve <strong>reliable and predictable results</strong> is at the heart of the design of the Xevo TQ-GC. The system has been rigorously tested to ensure that you <strong>spend less time on routine maintenance</strong>, and that it can be scheduled to fit around the laboratory workload, <strong>maximizing uptime</strong> and <strong>minimizing disruption</strong>.</p><p>To ensure you don’t spend your precious time on lengthy instrument setup, <strong>Intellistart health check</strong> informs you whether the system is ready to run injections and, if not, how the situation can be remedied. Your lab only needs <strong>minimal tools for instrument maintenance</strong>, and if any maintenance is needed, it is <strong>fast and mistake-proof</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_5_ebae58fe9d.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Repeatability from replicate (n=200) injection of grape extract containing five pesticides at 0.01 mg/kg." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_5_ebae58fe9d.jpg 245w," sizes="100vw" width="1024" height="541"></p></div></div><div><div><h3><strong>Achieve efficiency and flexibility</strong></h3><p>In a busy analytical lab, time is precious, especially when demands change regularly and the requirement for shorter turnaround times is increasing. With <strong>Quanpedia</strong>, you can easily deal with a wide variety of sample matrices, target analytes and gas chromatography (GC) conditions. The <strong>fully customizable database</strong> means that you no longer need to be concerned about having the flexibility to adapt to changes in regulations, as it contains compound classes that are most relevant to regulations, and modifications to existing methods are quick and simple. You can reduce your method development time by including automatic scheduling of multiple reaction monitoring (MRM) transitions that account for any shift in retention times that occur because of column maintenance.</p><p>You can also <strong>shorten turnaround times</strong> by <strong>increasing the number of components in a single analytical run</strong>, which is enabled by <strong>acquisition rates of up to 500 MRM/sec</strong> with no significant degradation in performance. This means more MRM transitions can be added to a run while still achieving high quality results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_caab24f949.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Generation of GC-MS acquisition and processing methods is performed automatically." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_caab24f949.jpg 245w," sizes="100vw" width="1024" height="546"></p></div></div><div><div><h3><strong>Capture the whole picture in targeted analyses</strong></h3><p>Reduce the risks to method performance and data quality associated with undetected interferences and unexpected compounds when conducting targeted analysis. <strong>RADAR improves method development and aids troubleshooting</strong> with the ability to detect and confirm analytes not specifically targeted through NIST library confirmation and routinely characterize unexpected contaminants. With this additional information, you can be completely confident in your data and avoid additional confirmatory analyses.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_2_48915d33e6.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Use of RADAR and NIST library search to identify a co-extracted compound in green tea matrix." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_2_48915d33e6.jpg 245w," sizes="100vw" width="1024" height="286"></p></div></div><div><div><h3><strong>Confidently meet regulatory demands</strong></h3><p>To ensure confidence in results, most analysts would prefer to operate comfortably below regulatory limits. You can achieve this confidence with Xevo TQ-GC, not only through <strong>reliable high performance</strong> but also as a result of <strong>TargetLynx</strong>, an Application Manager common across Waters LC and GC platforms. This means it not only gives full analyte quantification, simplified review of results, and customizable reporting, but also provides a common platform between instrument types simplifying data processing and reducing time to results.</p><p>With <strong>Waters MassLynx Basic Security</strong>, you are in control. Ideal for laboratories who need to manage or control access to a GC-MS system. MassLynx Basic Security contains an events audit log for added traceability for audits and accreditation, and the security can also be used with TargetLynx acquisition software.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_GC_Mass_Spectrometry_System_3_a0c5238bfe.jpg" alt="Waters Xevo TQ-GC Mass Spectrometry System: Comprehensive and streamlined results review with TargetLynx flags any results outside user-defined tolerances." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_GC_Mass_Spectrometry_System_3_a0c5238bfe.jpg 245w," sizes="100vw" width="1024" height="499"></p></div></div></div></div></div></div></div></div>

Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.

<h3><strong>Quantitate with Absolute Power</strong></h3><ul><li><strong>Harness Absolute Power for Confident, Fast Decisions</strong></li></ul><p><strong>The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.</strong></p><h4><strong>Absolute&nbsp;Performance</strong></h4><p>Achieve lower limits of quantitation to meet regulatory requirements with up to <strong>15x more sensitivity</strong> for challenging negative ionizing compounds than the previous product.</p><h4><strong>Absolute Efficiency &nbsp;</strong></h4><p>Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses <strong>up to 50% less electricity and gas and produces 50% less heat</strong> than most other high performance TQ mass spectrometry instruments on the market.</p><h4><strong>Absolute&nbsp;Productivity</strong></h4><p>Boost your productivity with flexible software solutions, including waters_connect,™ the modern, intuitive informatics solution that can<strong> save up to 50% of your data review time </strong>while facilitating data integrity.&nbsp;</p><h4><strong>Absolute Confidence</strong></h4><p>Ensure consistent robustness and reproducibility so you can <strong>maintain performance and productivity </strong>over a longer time period.</p><h3><strong>Absolute Performance</strong></h3><h4><strong>Increased sensitivity with lower limits of quantitation</strong></h4><p>One of the largest challenges facing many labs is the need to achieve lower limits of quantitation and meet regulatory requirements, particularly for challenging negative ionizing compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: *Xevo TQ Absolute shows up to 15x better ion response as compared to the Xevo TQ-XS and up to 6x better ion response than another leading high-performance LC-MS/MS instrument." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/thumbnail_Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp 245w," sizes="100vw" width="1024" height="540"></p><p>Ensure you have the confidence in your data to make decisions fast with an instrument that provides Absolute Performance. <strong>Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds</strong> than the previous product, so you can make decisions quickly and efficiently.</p><h3><strong>Absolute Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.&nbsp;</p><p>Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. During development of the Xevo TQ Absolute, Waters has addressed these challenges by providing an instrument with lower electricity consumption, gas consumption, and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p>The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, enabling laboratory managers to fully optimize their facilities and increase efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute Efficiency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg 206w," sizes="100vw" width="1050" height="794"></p><p>*Source: <a target="_blank" rel="noopener noreferrer" href="https://sciex.com/content/dam/SCIEX/pdf/customer-docs/site-planning-guide/7500-site-planning-guide-en.pdf">https://sciex.com/</a></p><h3><strong>Absolute Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions&nbsp;</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ Absolute is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements</p><h5><strong>waters_connect</strong></h5><p>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><h5><strong>MassLynx</strong></h5><p>Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Absolute Confidence</strong></h3><h4><strong>Tackle your toughest challenges</strong></h4><p>Analytical laboratories face several challenges that are constantly changing, so it’s important to have Absolute Confidence that your analytical instrumentation can keep pace.&nbsp;</p><p>The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility, so you can maintain performance and productivity over a longer time period.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: New source shield technology featured in the Xevo TQ Absolute Mass Spectrometer minimizes contamination and increases uptime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/thumbnail_Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Better by design</strong></h4><p>Optimal probe positioning guidance ensures you can achieve the best possible performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument. A new source shield maximizes uptime by minimizing contamination of the source from sample matrix or mobile phase salts.</p><h3><strong>Absolute Support</strong></h3><h4><strong>Ensure your success with world-renowned services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute support." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/thumbnail_Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp 234w," sizes="100vw" width="1024" height="682"></p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ Absolute, you can:</strong></p><h4><strong>Get Up And Running Quicly</strong></h4><p>Get the onsite training and consultation you need to integrate the Xevo TQ Absolute into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet Your Lab’s Unique Requirements&nbsp;</strong></h4><p>Protect your high-performance instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitates Compliance</strong></h4><p>Simplify the process of qualification, validation, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce Total Cost Of Ownership</strong></h4><p>FlexCAPITAL<strong>** </strong>is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage Your Existing Technology</strong></h4><p>With the FlexUP technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ Absolute – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>** </strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Products from category Triple quadrupoles - page 1

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