Separation and Detection of TCA Cycle Metabolites and Related Compounds in Human Urine by UPLC-MS/MS for Clinical Research

[ APPLICATION NOTE ] Separation and Analysis of TCA Cycle Analytes by Mixed-Mode Chromatography Coupled with Mass Spectrometry Kerri M. Smith and Paul Rainville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION A reproducible LC-MS method for the…

Improving sensitivity for the quantification of TCA cycle analytes in human plasma by the ACQUITY™ Premier system solution Kerri M Smith, Paul. D Rainville Waters Corporation, Milford, MA, USA LC System: ACQUITY™ Premier LC MS: XEVO TQ-Smicro, ESI negative Column:…

Ion Pairing Free Mixed-Mode Chromatography for the Separation and Measurement of TCA Cycle Metabolites in Urine Samples of Breast Cancer Patients Kerri M Smith, Giorgis Isaac, Suraj Dhungana and Paul D. Rainville Waters Corporation, Milford MA RESULTS and DISCUSSION Additional…

Application Note Clinical Research Quantitation of TCA Cycle Metabolites with LC/TQ and Standardized HILIC Chromatography Analyzing TCA metabolites in bovine plasma and cell samples using the Agilent 6495D triple quadrupole LC/MS and the Agilent 1290 Infinity II bio LC system…