SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES VIA AUTOMATED TOP-DOWN SPECTRAL ANNOTATION

SEQUENCE CONFIRMATION OF OLIGONUCLEOTIDES VIA AUTOMATED TOP-DOWN SPECTRAL ANNOTATION Maria Basanta-Sanchez, Catalin Doneanu, Joe Fredette, Barbara Sullivan, Weibin Chen and Iggy Kass Waters Corporation, Milford, MA OVERVIEW RESULTS METHODS Sequence analysis / confirmation of full length modified and non- Materials…

Application Note Pharma & Biopharma Oligonucleotides Oligonucleotide Characterization by Agilent 1290 Infinity II Bio LC and 6545XT AdvanceBio LC/Q-TOF Oligonucleotide identity, impurities analysis and sequence determination using BioConfirm 12.0 target plus impurities (TPI) and sequence confirmation workflows Authors Introduction Bian…

Application Note Biopharma/Pharma Comprehensive and Integrated Workflow for Oligonucleotide Sequence Confirmation by Agilent High-Resolution LC/Q-TOF Robust and sensitive sequence confirmation of synthetic oligonucleotides and impurities Authors David L. Wong and Peter Rye Agilent Technologies, Inc. Abstract This application note demonstrates…

Application Note BioPharma MS/MS Oligonucleotide Sequencing Using LC/Q-TOF with HILIC Chromatography Authors Guannan Li and Peter Rye Agilent Technologies, Inc. Introduction Oligonucleotides are commonly analyzed by liquid chromatography/mass spectrometry (LC/MS) in negative ion polarity mode using ion-pairing reversed‑phase (IP‑RP) methods.…