Separation and Analysis of Low Molecular Weight Organic Acid Metabolites by Mixed-Mode Chromatography Coupled to Mass Spectrometry

[ APPLICATION NOTE ] Separation and Analysis of TCA Cycle Analytes by Mixed-Mode Chromatography Coupled with Mass Spectrometry Kerri M. Smith and Paul Rainville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION A reproducible LC-MS method for the…

Ion Pairing Free Mixed-Mode Chromatography for the Separation and Measurement of TCA Cycle Metabolites in Urine Samples of Breast Cancer Patients Kerri M Smith, Giorgis Isaac, Suraj Dhungana and Paul D. Rainville Waters Corporation, Milford MA RESULTS and DISCUSSION Additional…

High Sensitivity Metabolite Screening with ionKey/MS Using Post-Column Addition Angela Doneanu, Jim Murphy, and Paul Rainville Waters Corporation, Milford, MA, USA A P P L I C AT I O N B E N E F I T S INT…

[ APPLICATION NOTE ] Evaluation of Ion Mobility/Tof Mass Spectrometry with Multiple LC Method Parameters for Enhanced Detection in Metabolic Profiling Paul D. Rainville,1 Ian D. Wilson, 2 and Robert S. Plumb 1,2 1 Waters Corporation, Milford, MA, USA 2…