TANDEM QUADRUPOLE MS FOR THE QUANTIFICATION OF MONOCLONAL ANTIBODY SUBUNIT LIGHT CHAINS IN PLASMA

[ APPLICATION NOTE ] Triple Quadrupole Mass Spectrometry (Xevo TQ-XS) for the Quantification of Monoclonal Antibody Light Chains in Plasma Caitlin M. Dunning, Mary Lame, and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ Fast, reproducible, and…

[ TECHNOLOGY BRIEF ] Tackling Non-Specific Binding of Biotherapeutics Using LC-MS Compatible QuanRecovery Sample Plates with MaxPeak High Performance Surfaces Caitlin Dunning, Mary Lame, Mark Wrona, and Kim Haynes Waters Corporation, Milford, MA, USA Large, hydrophobic biomolecules are prone to…

[ APPLICATION NOTE ] Accurate and Sensitive LC-MS/MS Quantification of Adalimumab in Serum/Plasma: Impact of Sample Preparation on Method Performance Caitlin Dunning, Mary Lame, Steven Calciano, and Kelly Doering Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Speed and…

[ APPLICATION NOTE ] Development of a Hybrid Immunoaffinity-LC-MS/MS Method for the Quantification of Active Biotherapeutics Targeting TNF-α in Serum Caitlin Dunning and Mary Lame Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ High analytical sensitivity Tumor Necrosis Factor…