High-Throughput LC/MS Purification of Pharmaceutical Impurities

Application Note Pharma & Biopharma Efficient Purification of Crude Samples in Early-Stage Drug Discovery Using the Agilent 1290 Infinity II Preparative LC/MSD System Authors Sonja Schipperges and Florian Rieck Agilent Technologies, Inc. Abstract In early-stage drug discovery, high-purity compounds are…

Automated Purification of Compound Libraries Using the Agilent 1260 Infinity Automated LC/MSD Purification System Technical Overview Author Abstract Florian Rieck Purifying a large number of compounds by liquid chromatography usually requires Agilent Technologies, Inc. screening experiments and manual interaction during…

Technical Overview Developing Purification Strategies for the Agilent 1260 Infinity II Preparative LC/MSD System Author Florian Rieck Agilent Technologies, Inc. Waldbronn, Germany Abstract Peak-based fraction collection triggered by a UV signal threshold leads to satisfactory results in most cases. Some…

Application Note Pharmaceutical Small Molecules Isolate and Reanalyze Pharma Impurities with the Agilent 1290 Infinity II Autoscale Preparative LC/MSD System API Author Florian Rieck Agilent Technologies, Inc. Abstract Isolation of impurities for further characterization is a routine task in the…