Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterization of biotherapeutic proteins

Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterization of biotherapeutics proteins. Stephane Houel1, Terry Zhang1, Erin Redman2, Scott Mellors2, Aaron Bailey1, Chris Petty2, Aran Paulus1, Kai Zhou1, Jonathan Josephs1., 1Thermo Fisher Scientific, San…

A comprehensive CE/ESI-MS solution for BioPharma applications Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometers with ZipChip system Fast CE Separation Nanospray Sensitivity HRAM Spectrometry A unique and powerful combination of CE/ESI and MS technology designed for BioPharmaceutical applications Thermo…

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APPLICATION NOTE 72358 Quick screening of intact antibody and antibodydrug conjugates with integrated microfluidic capillary electrophoresis and mass spectrometry Authors Chien-Hsun Alex Chen,1 Stephane Houel,1 Terry Zhang,1 Brian J. Agnew,2 Shanhua Lin,3 Kai Zhou,1 Jonathan Josephs,1 Aran Paulus,1 and Andreas…