A Rapid UPLC-MS/MS Discovery Bioanalytical Method for the Quantification of Gefitinib and Four of Its Major Metabolites in Mouse Plasma

Application Note A Streamlined Workflow for Quantitative Bioanalysis using waters_connect for Quantitation Software: A Case Study Using Gefitinib Robert Plumb Waters Corporation, United States Published on November 20, 2025 Abstract Preclinical and early human drug metabolism and pharmacokinetics (DMPK) studies…

Application Note Visualization of Gefitinib and Related Metabolites in Rat Liver Using DESI-Tandem Quadrupole Mass Spectrometry Robert Plumb, Anthony Midey Waters Corporation, United States Published on August 07, 2026 Abstract Detection and measurement of drugs, their metabolites, and biomarkers in…

[ APPLICATION NOTEBOOK ] Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape Small Molecules Oligonucleotide Protein/Peptide Therapeutics Software Tools Targeted Imaging LC-MS/MS Solutions to Support Reliable, Sensitive and Efficient Workflows for the Bioanalysis of Drug Modalities Welcome to the Waters…

Application Note Rapid Identification of Major Metabolites of Gefitinib Using Ion Mobility Enabled MS (HDMSE) with the SYNAPT XS Robert S. Plumb, Lauren Mullin, Adam King, Ian D. Wilson Waters Corporation, Computational and Systems Medicine, Imperial College Abstract This application…