Reliable HPLC/UV Quantification of Nitrosamine Impurities in Valsartan and Ranitidine Drug Substances

[ TECHNOLOGY BRIEF ] Highly Sensitive and Robust UPLC-MS/MS Quantification of Nitrosamine Impurities in Sartan and Ranitidine Drug Substances Lindsay Hatch, Mary Lame, Dave Higton, Paul Rainville, and Gordon Fujimoto Waters Corporation, Milford, MA, USA The Xevo TQ-XS Mass Spectrometer,…

[ TECHNOLOGY BRIEF ] Use of a Proprietary Polar Column Chemistry for the Separation of Nitrosamines in Sartan and Ranitidine Drug Substances Margaret Maziarz, Sherri Naughton, and Paul Rainville Waters Corporation, Milford, MA, USA The XSelect HSS T3 Column enables…

APPLICATION NOTE 65911 Determination of six nitrosamine impurities in angiotensin II receptor blocker drugs by LC-MS/MS Authors: Sunil Kumar, Varun Khali, Manoj Kushwaha, Dr. Biswajayee Patra, Thermo Fisher Scientific India Private Limited-Delhi, India Keywords: TSQ Quantis triple quadrupole mass spectrometer,…

Nitrosamine Impurities Application Guide Confidently Detect and Quantify Mutagenic Impurities in APIs and Drug Products Sartan-Based Losartan Valsartan Candesartan Telmisartan Metformin Ranitidine Nitrosamines are formed by chemical reactions that occur during API manufacturing whether from starting materials, intermediates, reactants, reuse…