Analysis of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients (2)

LAAN-J-MS-E018B GCMS Gas Chromatograph Mass Spectrometer Analysis of Potential Genotoxic Impurities in Active Pharmaceutical Ingredients 18B Chemicals such as methanesulfonic acid (mesylate), benzenesulfonic acid (besilate), and p-toluenesulfonic acid (tosylate) are used in the process of synthesizing active pharmaceutical ingredients. These…

Coupling Mass Detection with UV to Improve Method Sensitivity for Esters of Benzenesulfonic Acid in Analysis of Genotoxic Impurities Margaret Maziarz and Mark Wrona Waters Corporation, Milford, MA, USA A P P L I C AT I O N B…

Application Note No. 62 Analysis of Pharmaceuticals’ Impurity - Regulations and Analysis for Carcinogenic Substances Dheeraj Handique *a), Nitish Suryawanshi *a), Crystal Yeong *b), Cynthia Lahey *b), Shailendra Rane *a), Deepti Bhandarkar *a), Anant Lohar *a), Gao Jie san *c),…

APPLICATION BRIEF 73116 Accurate and reliable quantitation of p-toluenesulfonates genotoxic impurities in an active pharmaceutical ingredient by HPLC-UV Authors Sylvia Grosse, Mauro De Pra, Frank Steiner Thermo Fisher Scientific, Germering, Germany Keywords Genotoxic impurities, p-toluenesulfonates, active pharmaceutical ingredient, aprepitant, UV…