Novel capillary-flow LC HRAM MS platform for fast targeted analysis and robust profiling of complex samples

Ultra-Fast Capillary-Flow LC-MS Profiling of Complex Biological Matrices: Applicable to Large Sample Cohorts Oleksandr Boychenko1; Jenny Ho2; Christopher Pynn1 1Thermo Fisher Scientific, Germering, Germany; 2Thermo Fisher Scientific, Hemel Hempstead, UK ABSTRACT OPTIMIZED HIGH-THROUGHPUT LC-MS METHODS LOW-FLOW LC-MS ANALYSIS OF HELA…

The Thermo Scientific Capillary-Flow LC-MS Solutions The world leader in serving science Content • Thermo Scientific™ LC-MS front-end UHPLC portfolio • Advantages of CapLC-MS and Fields of Application • The Thermo Scientific™ CapLC-MS solution • Application Examples • Available Additional…

TECHNICAL NOTE 72277 Capillary-flow LC-MS: combining high sensitivity, robustness, and throughput Authors Alexander Boychenko, Stephan Meding, Wim Decrop, Martin Ruehl, Remco Swart Thermo Fisher Scientific, Germering, Germany Keywords Capillary-flow LC-MS, capLC-MS, sensitivity, throughput, direct injection, preconcentration onto trap cartridge, robustness,…

high retention time precision. This allowed to multiplex ASGYTFTSYNMHWVK targeted assays by using 1791.8165 narrow column STYYGGDWYFNVWGAGTTVTVSAASTK 2889.3372 retention time windows and obtain highly reproducible results. Methods Q Exactive HF UltiMate 3000 RSLCnano Liquid Chromatography SSSTAYMQLSSLTSEDSAVYYCAR 2677.1848 Light chain chimeric…